AR084529A2 - Un metodo para la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados - Google Patents
Un metodo para la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebradosInfo
- Publication number
- AR084529A2 AR084529A2 ARP110104870A AR084529A2 AR 084529 A2 AR084529 A2 AR 084529A2 AR P110104870 A ARP110104870 A AR P110104870A AR 084529 A2 AR084529 A2 AR 084529A2
- Authority
- AR
- Argentina
- Prior art keywords
- prrsv
- production
- virus
- respiratory syndrome
- crop
- Prior art date
Links
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 title abstract 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000001850 reproductive effect Effects 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0688—Cells from the lungs or the respiratory tract
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/12011—Asfarviridae
- C12N2710/12051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un método para la producción del Virus del Síndrome Reproductor y Respiratorio Porcino (PRRSV) a partir de un cultivo de células de vertebrados que comprende los pasos de: (a) proveer una célula recombinante de vertebrados transfectada con un polinucleótido exógeno que codifica un polipéptido de mamífero CD163 que tiene un dominio de transmembrana y al menos 70%, exceptuando el 100%, de identidad de secuencia con la SEQ ID Nº 14, tal que la expresión del polipéptido CD163 en dicha célula se incrementa; (b) poner en contacto un cultivo de dicha célula con virus PRRSV bajo condiciones que permiten la infección de las células y el crecimiento del virus; y (c) recuperar el virus de dicho cultivo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56521404P | 2004-04-23 | 2004-04-23 | |
| US63473604P | 2004-12-09 | 2004-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084529A2 true AR084529A2 (es) | 2013-05-22 |
Family
ID=35320736
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101615 AR049033A1 (es) | 2004-04-23 | 2005-04-22 | Factor de permisividad celular para virus y usos del mismo |
| ARP110104870 AR084529A2 (es) | 2004-04-23 | 2011-12-21 | Un metodo para la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados |
| ARP110104871 AR084530A2 (es) | 2004-04-23 | 2011-12-21 | Un metodo para facilitar la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101615 AR049033A1 (es) | 2004-04-23 | 2005-04-22 | Factor de permisividad celular para virus y usos del mismo |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104871 AR084530A2 (es) | 2004-04-23 | 2011-12-21 | Un metodo para facilitar la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US7754464B2 (es) |
| EP (2) | EP1742658B1 (es) |
| JP (2) | JP5273642B2 (es) |
| CN (1) | CN102220289B (es) |
| AR (3) | AR049033A1 (es) |
| AU (2) | AU2005240002B2 (es) |
| BR (1) | BRPI0508928B1 (es) |
| CA (1) | CA2564769C (es) |
| CL (1) | CL2008002323A1 (es) |
| DK (1) | DK1742658T3 (es) |
| EA (1) | EA013071B1 (es) |
| ES (2) | ES2530694T3 (es) |
| HK (1) | HK1109065A1 (es) |
| IL (1) | IL178160A0 (es) |
| MA (1) | MA28544B1 (es) |
| MX (1) | MXPA06012216A (es) |
| NO (1) | NO341211B1 (es) |
| NZ (1) | NZ550145A (es) |
| PL (1) | PL1742658T3 (es) |
| TW (2) | TWI354025B (es) |
| UY (1) | UY28867A1 (es) |
| WO (1) | WO2005107796A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005240002B2 (en) * | 2004-04-23 | 2009-06-18 | Zoetis Services Llc | Cellular permissivity factor for viruses, and uses thereof |
| CA2675139C (en) | 2007-01-12 | 2019-02-19 | The Board Of Trustees Of The University Of Illinois | Non-simian cells for growth of porcine reproductive and respiratory syndrome (prrs) virus |
| EP2191271B1 (en) * | 2007-07-27 | 2016-01-13 | Universiteit Gent | Permissive cells and uses thereof |
| UA108902C2 (uk) * | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
| MX2014013964A (es) * | 2012-05-17 | 2015-03-04 | Zoetis Llc | Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete. |
| CN103525766B (zh) * | 2013-03-24 | 2015-06-17 | 西北农林科技大学 | 一种猪肾细胞系及其应用 |
| GB201313235D0 (en) | 2013-07-24 | 2013-09-04 | Univ Edinburgh | Antiviral Compositions Methods and Animals |
| CN104459160A (zh) * | 2014-12-30 | 2015-03-25 | 洛阳普莱柯万泰生物技术有限公司 | 试剂盒及其制备方法和使用方法 |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| MX2019006992A (es) | 2016-12-14 | 2019-08-29 | Zoetis Services Llc | Vacunacion eficaz contra cepas europeas del virus del sindrome reproductivo y respiratorio porcino (prrs) previo al destete. |
| CN108103099B (zh) * | 2017-12-18 | 2022-03-04 | 中山大学 | 一种抗蓝耳病Marc-145细胞系及其制备方法和应用 |
| CN108893450B (zh) * | 2018-08-13 | 2022-04-19 | 江苏省农业科学院 | 先天性免疫系统重构的bhk21细胞群及其细胞克隆增毒应用 |
| CN111996213A (zh) * | 2020-02-06 | 2020-11-27 | 广西大学 | 猪繁殖与呼吸综合征病毒双荧光标记基因重组毒株的构建方法 |
| KR102254246B1 (ko) * | 2020-03-23 | 2021-05-20 | 큐벳 주식회사 | 항-cd163 항체 또는 이의 항원 결합 단편을 인코딩하는 핵산 분자 및 이를 포함하는 아데노바이러스 벡터, 및 이의 아프리카 돼지열병의 예방 또는 치료용도 |
| US11796548B2 (en) * | 2020-04-22 | 2023-10-24 | The United States Of America, As Represented By The Secretary Of Agriculture | Continuous stable cell line for identification of infectious African swine fever virus in clinical samples |
| WO2024123640A1 (en) | 2022-12-06 | 2024-06-13 | Zoetis Services Llc | Methods and compositions for vaccinating piglets against prrs-1 virus |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622871A (en) | 1987-04-27 | 1997-04-22 | Unilever Patent Holdings B.V. | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5118937A (en) | 1989-08-22 | 1992-06-02 | Finnigan Mat Gmbh | Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules |
| AU645294B2 (en) | 1989-12-22 | 1994-01-13 | Merck Serono Sa | Endogenous gene expression modification with regulatory element |
| AU651596B2 (en) | 1990-06-05 | 1994-07-28 | Immunex Corporation | Type II interleukin-1 receptors |
| CA2092695A1 (en) | 1991-05-15 | 1992-11-16 | Oliver Smithies | Genomic modifications with homologous dna targeting |
| US5846805A (en) | 1991-08-26 | 1998-12-08 | Boehringer Ingelheim Animal Health, Inc. | Culture of swine infertility and respiratory syndrome virus in simian cells |
| US5514545A (en) | 1992-06-11 | 1996-05-07 | Trustees Of The University Of Pennsylvania | Method for characterizing single cells based on RNA amplification for diagnostics and therapeutics |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| ATE242485T1 (de) | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| ATE206455T1 (de) * | 1994-04-11 | 2001-10-15 | Akzo Nobel Nv | Europäische vakzinstämme des fortplanzungs- atmungs-syndromsvirus des schweins |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| WO1998035023A1 (en) * | 1997-02-07 | 1998-08-13 | Origen, Inc. | Method for growing porcine reproductive and respiratory syndrome virus for use as vaccines and diagnostic assays |
| US6740490B2 (en) * | 2001-01-29 | 2004-05-25 | Kansas State University Research Foundation | Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding |
| US7563881B2 (en) | 2001-07-24 | 2009-07-21 | Intervet International B.V. | Nucleic acid encoding polypeptide involved in cellular entrance of the PRRS virus |
| WO2003100419A1 (en) * | 2002-05-27 | 2003-12-04 | Bioceros B.V. | Methods for using the cd163 pathway for modulating an immune response |
| AU2005240002B2 (en) * | 2004-04-23 | 2009-06-18 | Zoetis Services Llc | Cellular permissivity factor for viruses, and uses thereof |
-
2005
- 2005-04-05 AU AU2005240002A patent/AU2005240002B2/en active Active
- 2005-04-05 EP EP05736317.8A patent/EP1742658B1/en active Active
- 2005-04-05 PL PL05736317T patent/PL1742658T3/pl unknown
- 2005-04-05 CN CN201110127305.5A patent/CN102220289B/zh active Active
- 2005-04-05 NZ NZ550145A patent/NZ550145A/en unknown
- 2005-04-05 EP EP12178283.3A patent/EP2520310B1/en active Active
- 2005-04-05 DK DK05736317T patent/DK1742658T3/en active
- 2005-04-05 JP JP2007509491A patent/JP5273642B2/ja active Active
- 2005-04-05 WO PCT/US2005/011502 patent/WO2005107796A2/en active Application Filing
- 2005-04-05 ES ES05736317T patent/ES2530694T3/es active Active
- 2005-04-05 MX MXPA06012216A patent/MXPA06012216A/es active IP Right Grant
- 2005-04-05 CA CA2564769A patent/CA2564769C/en active Active
- 2005-04-05 ES ES12178283T patent/ES2570665T3/es active Active
- 2005-04-05 EA EA200601677A patent/EA013071B1/ru not_active IP Right Cessation
- 2005-04-05 BR BRPI0508928A patent/BRPI0508928B1/pt active IP Right Grant
- 2005-04-20 TW TW94112572A patent/TWI354025B/zh active
- 2005-04-20 TW TW100121989A patent/TWI438278B/zh active
- 2005-04-22 UY UY28867A patent/UY28867A1/es not_active Application Discontinuation
- 2005-04-22 AR ARP050101615 patent/AR049033A1/es active IP Right Grant
- 2005-04-25 US US11/113,751 patent/US7754464B2/en active Active
-
2006
- 2006-09-18 IL IL178160A patent/IL178160A0/en unknown
- 2006-10-20 MA MA29400A patent/MA28544B1/fr unknown
- 2006-11-06 NO NO20065115A patent/NO341211B1/no unknown
-
2007
- 2007-12-31 HK HK07114307A patent/HK1109065A1/xx unknown
-
2008
- 2008-08-07 CL CL2008002323A patent/CL2008002323A1/es unknown
-
2009
- 2009-06-16 AU AU2009202410A patent/AU2009202410A1/en not_active Abandoned
-
2010
- 2010-05-06 US US12/775,283 patent/US8058050B2/en active Active
-
2011
- 2011-09-29 US US13/248,537 patent/US8486685B2/en active Active
- 2011-12-21 AR ARP110104870 patent/AR084529A2/es unknown
- 2011-12-21 AR ARP110104871 patent/AR084530A2/es unknown
-
2012
- 2012-11-22 JP JP2012256338A patent/JP5600340B2/ja active Active
-
2013
- 2013-07-12 US US13/940,317 patent/US9102912B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR084529A2 (es) | Un metodo para la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados | |
| ES2533874T3 (es) | Armazón proteico | |
| ES2627117T3 (es) | Método basado en MGMT para obtener un rendimiento elevado de expresión de proteínas recombinantes | |
| CU20120006A7 (es) | Producción de títulos elevados de poliovirus para la producción de vacunas | |
| ATE470702T1 (de) | Verfahren zur herstellung von permanenten humanen zelllinien | |
| DK1918364T3 (da) | Fremgangsmåde til rekloning af produktionsceller | |
| AR088824A2 (es) | Metodo para la produccion de tnfr-ig (receptor de factor de necrosis tumoral-inmunoglobulina) | |
| PE20110358A1 (es) | Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias | |
| ES2689932T3 (es) | Construcciones de armazones de células | |
| CO5580165A1 (es) | Vacunas de rotavirus modificado | |
| AR057213A1 (es) | Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv | |
| WO2009074807A3 (en) | Methods | |
| CO6491059A2 (es) | Diferenciacion de las celulas madre mesenquimales | |
| DK2274419T3 (da) | Fremgangsmåder til fremstilling af hårmikrofollikler og de novopapiller og anvendelse heraf til in vitro-test og in vivo-implantationer | |
| ES2139591T3 (es) | Asialoglicoproteinas del virus de la hepatitis c. | |
| AR049177A1 (es) | Polipeptidos y conjugados de interferon-alfa | |
| ES2489715T3 (es) | Procedimiento para la produccíón de colágeno humano de tipo II | |
| AR241794A1 (es) | Procedimiento para obtener inteerleucina-2 humana, en una celula de ovario de hamster de la china. | |
| ES2479543T1 (es) | Poblaciones celulares que tienen actividad inmunorreguladora, métodos para la preparación y usos de las mismas | |
| AR058625A1 (es) | Produccion recombinante de proteinas de union a heparina | |
| DE602006014186D1 (de) | Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung | |
| ATE334592T1 (de) | Biologische bekämpfung von nematoden | |
| MX2021005721A (es) | Proceso de fabricacion de celulas t mejorado. | |
| AR045000A1 (es) | Gen y proteina de eimeria , y su uso | |
| CO2023003662A2 (es) | Estrategias de suministro de asparagina para mejorar el rendimiento del cultivo celular y mitigar las variantes de secuencia de asparagina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |