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AR052458A1 - Amino-imidazolonas para la inhibicion de beta-secretasa - Google Patents

Amino-imidazolonas para la inhibicion de beta-secretasa

Info

Publication number
AR052458A1
AR052458A1 ARP060100150A ARP060100150A AR052458A1 AR 052458 A1 AR052458 A1 AR 052458A1 AR P060100150 A ARP060100150 A AR P060100150A AR P060100150 A ARP060100150 A AR P060100150A AR 052458 A1 AR052458 A1 AR 052458A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
independently
alkyl
attached
cycloalkyl
Prior art date
Application number
ARP060100150A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR052458A1 publication Critical patent/AR052458A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Además se proveen composiciones y métodos para su uso, a fin de inhibir beta-secretasa (BACE) y tratar depositos beta- amiloideos y enredos neurofibrilares. Reivindicacion 1: Un compuesto de formula (1) donde. R1 y R2 son de manera independiente H o un grupo alquilo C1-4 opcionalmente sustituido, R3 y R4 son de manera independiente H o un grupo alquilo C1-4 opcionalmente sustituido; o R3 y R4 pueden tomarse juntos para formar un anillo de 4 a 7 miembros que, en forma opcional, contiene 1 o 2 heteroátomos seleccionados de O, N o S; R5, R6 y R7 son de manera independiente H, halogeno, NO2, CN, OR11, NR12R13 o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloheteroalquilo, arilo o aril- alquilo C1-4, donde cada uno está opcionalmente sustituido; o cuando están unidos a átomos de C adyacentes, R5 y R6 pueden tomarse junto con los átomos a los que están unidos para formar un anillo de 5 a 7 miembros opcionalmente sustituido, que en forma opcional, contiene 1 o 2 heteroátomos seleccionados de O, N o S; R8, R9 y R10 son de manera independiente H, halogeno, NO2, CN, OR14, NR15R16 o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloheteroalquilo, arilo o aril-alquilo C1-4, donde cada uno está opcionalmente sustituido; o cuando están unidos a átomos de C adyacentes, R8 y R9 pueden tomarse junto con los átomos a los que están unidos para formar un anillo de 5 a 7 miembros opcionalmente sustituido, que en forma opcional, contiene 1 o 2 heteroátomos seleccionados de O, N o S; n es 0, 1 o 2; R11 y R14 son de manera independiente H o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3- 8 o arilo, donde cada uno está opcionalmente sustituido; y R12, R13, R15 y r16 son de manera independiente H, alquilo C1-4, cicloalquilo C3-8, o R12 y R13, o R15 y R16, pueden tomarse junto con el átomo al que están unidos para formar un anillo de 5 a 7 miembros, que en forma opcional, contiene un heteroátomo adicional seleccionado de O, N o S; o un tautomero de dicho compuesto, un estereoisomero de dicho compuesto o una sal farmacéuticamente aceptable de dicho compuesto.
ARP060100150A 2005-01-14 2006-01-13 Amino-imidazolonas para la inhibicion de beta-secretasa AR052458A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64380505P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
AR052458A1 true AR052458A1 (es) 2007-03-21

Family

ID=36581776

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060100150A AR052458A1 (es) 2005-01-14 2006-01-13 Amino-imidazolonas para la inhibicion de beta-secretasa

Country Status (20)

Country Link
US (2) US7563796B2 (es)
EP (2) EP1836208A2 (es)
JP (1) JP2008526966A (es)
KR (1) KR20070095948A (es)
CN (1) CN101103034A (es)
AR (1) AR052458A1 (es)
AU (1) AU2006205127A1 (es)
BR (1) BRPI0606690A2 (es)
CA (1) CA2593515A1 (es)
CR (1) CR9244A (es)
GT (1) GT200600009A (es)
IL (1) IL183938A0 (es)
MX (1) MX2007008555A (es)
NO (1) NO20073099L (es)
PA (1) PA8660001A1 (es)
PE (1) PE20060842A1 (es)
RU (1) RU2007126570A (es)
TW (1) TW200637866A (es)
WO (1) WO2006076284A2 (es)
ZA (1) ZA200705783B (es)

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Also Published As

Publication number Publication date
KR20070095948A (ko) 2007-10-01
CA2593515A1 (en) 2006-07-20
US20090253716A1 (en) 2009-10-08
AU2006205127A1 (en) 2006-07-20
EP2264036A1 (en) 2010-12-22
BRPI0606690A2 (pt) 2009-07-14
WO2006076284A3 (en) 2007-04-19
US7563796B2 (en) 2009-07-21
CR9244A (es) 2007-09-07
PE20060842A1 (es) 2006-10-12
PA8660001A1 (es) 2006-09-08
WO2006076284A2 (en) 2006-07-20
JP2008526966A (ja) 2008-07-24
IL183938A0 (en) 2007-10-31
RU2007126570A (ru) 2009-02-20
EP1836208A2 (en) 2007-09-26
ZA200705783B (en) 2008-09-25
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