AR050551A1 - Fenilaminotiazoles sustituidos y su uso - Google Patents
Fenilaminotiazoles sustituidos y su usoInfo
- Publication number
- AR050551A1 AR050551A1 ARP050103664A ARP050103664A AR050551A1 AR 050551 A1 AR050551 A1 AR 050551A1 AR P050103664 A ARP050103664 A AR P050103664A AR P050103664 A ARP050103664 A AR P050103664A AR 050551 A1 AR050551 A1 AR 050551A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- alkyl
- substituted
- mono
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente solicitud se refiere a nuevos derivados de fenilaminotiazol, a procedimientos para su fabricacion, a su uso para el tratamiento y/o la profilxis de enfermedades, así como a su uso para la fabricacion de medicamentos para el tratamiento y/o la profilaxis de enfermedades, preferiblemente para el tratamiento y/o la prevencion de hipertension y otras enfermedades cardiovasculares. Reivindicacion 1: Compuesto de formula (1), en la que R1 representa hidrogeno o alquilo (C1-6), que puede estar sustituido con hidroxi, anino, mono- o dialquil (C1-4)amino, pirrolidino, piperidino, morfolino, piperazino o N'-metilpiperazino, R2 representa alquilo (C2-6), que está sustituido una o dos veces de forma igual o distinta con sustituyentes seleccionados del grupo de hidroxi, alcoxi (C1-4), amino, mono- y dialquil (C1-4)amino, R3 representa un sustituyente seleccionado del grupo de halogeno, ciano, nitro, alquilo (C1-6), hidroxi, alcoxi (C1-6), amino, mono- y di (C1- 6)alquilamino, carboxilo y alcoxi (C1-6)carbonilo, en la que alquilo y alcoxi pueden estar sustituidos a su vez respectivamente hasta cinco veces con fluor, y n representa el numero 0, 1, 2, 3, 4 o 5, en la que en el caso de que el sustituyente R3 aparezca varias veces, sus significados pueden ser iguales o distintos, así como sus sales, solvatos y solvatos de las sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004042607A DE102004042607A1 (de) | 2004-09-03 | 2004-09-03 | Substituierte Phenylaminothiazole und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050551A1 true AR050551A1 (es) | 2006-11-01 |
Family
ID=35852458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103664A AR050551A1 (es) | 2004-09-03 | 2005-09-01 | Fenilaminotiazoles sustituidos y su uso |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8691850B2 (es) |
| EP (1) | EP1812430B1 (es) |
| JP (1) | JP4999691B2 (es) |
| KR (1) | KR20070057235A (es) |
| CN (1) | CN101056875A (es) |
| AR (1) | AR050551A1 (es) |
| AT (1) | ATE428710T1 (es) |
| AU (1) | AU2005281941A1 (es) |
| BR (1) | BRPI0514833A (es) |
| CA (1) | CA2578596C (es) |
| DE (2) | DE102004042607A1 (es) |
| EC (1) | ECSP077296A (es) |
| ES (1) | ES2324049T3 (es) |
| GT (1) | GT200500238A (es) |
| IL (1) | IL181670A0 (es) |
| MA (1) | MA28869B1 (es) |
| MX (1) | MX2007002470A (es) |
| NO (1) | NO20071343L (es) |
| PE (1) | PE20060589A1 (es) |
| SV (1) | SV2006002218A (es) |
| TW (1) | TW200621765A (es) |
| UY (1) | UY29099A1 (es) |
| WO (1) | WO2006027142A1 (es) |
| ZA (1) | ZA200701820B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006009813A1 (de) * | 2006-03-01 | 2007-09-06 | Bayer Healthcare Ag | Verwendung von A2b/A1 Rezeptor Agonisten zur Modulation der Lipidspiegel |
| DE102006042143A1 (de) * | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006044696A1 (de) | 2006-09-22 | 2008-03-27 | Bayer Healthcare Ag | 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung |
| DE102006056740A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056739A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102007035367A1 (de) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102007061764A1 (de) | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellierte Cyanopyridine und ihre Verwendung |
| DE102007061763A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituierte azabicyclische Verbindungen und ihre Verwendung |
| DE102008008838A1 (de) | 2008-02-13 | 2009-08-20 | Bayer Healthcare Ag | Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung |
| DE102008013587A1 (de) * | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| ES2428818T3 (es) * | 2008-05-29 | 2013-11-11 | Bayer Intellectual Property Gmbh | Dicianopiridinas sustituidas con 2-alcoxi y su uso |
| DE102008062567A1 (de) * | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| DE102009022894A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
| WO2018153895A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit einem inhibitor der neutralen endopeptidase und/oder einem angiotensin ii rezeptor-antagonisten |
| WO2018153897A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit hcn-kanal-hemmern |
| WO2018153899A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc) |
| WO2018153900A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit sglt-2-hemmern |
| WO2018153898A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten |
| JP7323913B2 (ja) * | 2019-04-12 | 2023-08-09 | 国立大学法人 筑波大学 | 睡眠誘導剤である複素環化合物 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW299333B (es) | 1992-12-29 | 1997-03-01 | Takeda Pharm Industry Co Ltd | |
| CN1056611C (zh) | 1994-06-16 | 2000-09-20 | 美国辉瑞有限公司 | 吡唑并吡啶和吡咯并吡啶,其用途和用于制备它们的中间体 |
| JPH09132529A (ja) | 1995-11-09 | 1997-05-20 | Ono Pharmaceut Co Ltd | 一酸化窒素合成酵素阻害剤 |
| AU727775B2 (en) | 1996-01-17 | 2000-12-21 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| JPH10324687A (ja) | 1997-02-19 | 1998-12-08 | Nippon Soda Co Ltd | ピロール化合物、製法および農園芸用殺菌剤 |
| WO1998054139A1 (de) | 1997-05-30 | 1998-12-03 | Basf Aktiengesellschaft | Verfahren zur herstellung substituierter thiopyridine |
| CA2294830A1 (en) | 1997-07-16 | 1999-01-28 | John Bondo Hansen | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
| US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19947154A1 (de) | 1999-10-01 | 2001-10-04 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| CA2398274C (en) | 2000-02-25 | 2009-09-22 | F. Hoffmann-La Roche Ag | Adenosine receptor modulators |
| CA2415899A1 (en) | 2000-07-18 | 2003-01-13 | Chikashi Saitoh | Medicine comprising dicyanopyridine derivative |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| WO2002048115A2 (en) | 2000-12-11 | 2002-06-20 | E. I. Du Pont De Nemours And Company | Quinazolinones and pyridinopyrimidinones for controlling invertebrate pests |
| HUP0303538A2 (hu) | 2000-12-21 | 2005-02-28 | Bristol-Myers Squibb Co. | Tirozin kinázok Tec családjának tiazolil-vegyület inhibitorai és ezeket tartalmazó gyógyszerkészítmények |
| DE10110438A1 (de) | 2001-03-05 | 2002-09-19 | Bayer Ag | Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110754A1 (de) | 2001-03-07 | 2002-09-19 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10110747A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung |
| DE10115922A1 (de) | 2001-03-30 | 2002-10-10 | Bayer Ag | Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10115945A1 (de) | 2001-03-30 | 2002-10-02 | Bayer Ag | Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10134481A1 (de) * | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
| DE10238113A1 (de) * | 2001-12-11 | 2003-06-18 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
| JP2003183254A (ja) | 2001-12-20 | 2003-07-03 | Yamanouchi Pharmaceut Co Ltd | ２−アシルアミノ−３，５−ジシアノピリジン誘導体又はその塩 |
| EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| EP1388342A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
| JP2006501217A (ja) | 2002-08-12 | 2006-01-12 | スージェン・インコーポレーテッド | 新規キナーゼ阻害剤としての３−ピロリル−ピリドピラゾールおよび３−ピロリル−インダゾール |
| BR0317183A (pt) | 2002-12-12 | 2005-11-01 | Pharmacia Corp | Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno |
| AR042667A1 (es) | 2002-12-26 | 2005-06-29 | Taisho Pharmaceutical Co Ltd | Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico |
| TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| US7692017B2 (en) | 2003-09-23 | 2010-04-06 | Merck Sharp & Dohme Corp. | Quinoline potassium channel inhibitors |
| US7338951B2 (en) | 2003-11-10 | 2008-03-04 | Synta Pharmaceuticals Corp. | Pyridine compounds |
| US20050182105A1 (en) | 2004-02-04 | 2005-08-18 | Nirschl Alexandra A. | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function |
| JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
| DE102004032651A1 (de) | 2004-07-06 | 2006-02-16 | Bayer Healthcare Ag | Verwendung von substituierten 2-Thio-3,5-dicyano-4-phenyl-6-aminopyriden bei der Behandlung von Übelkeit und Erbrechen |
| DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006056739A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056740A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102007035367A1 (de) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102008013587A1 (de) | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
-
2004
- 2004-09-03 DE DE102004042607A patent/DE102004042607A1/de not_active Withdrawn
-
2005
- 2005-08-30 CN CNA2005800381572A patent/CN101056875A/zh active Pending
- 2005-08-30 EP EP05776232A patent/EP1812430B1/de active Active
- 2005-08-30 KR KR1020077007526A patent/KR20070057235A/ko not_active Application Discontinuation
- 2005-08-30 AT AT05776232T patent/ATE428710T1/de not_active IP Right Cessation
- 2005-08-30 US US11/661,820 patent/US8691850B2/en not_active Expired - Fee Related
- 2005-08-30 CA CA2578596A patent/CA2578596C/en not_active Expired - Fee Related
- 2005-08-30 JP JP2007529331A patent/JP4999691B2/ja not_active Expired - Fee Related
- 2005-08-30 AU AU2005281941A patent/AU2005281941A1/en not_active Abandoned
- 2005-08-30 WO PCT/EP2005/009316 patent/WO2006027142A1/de active Application Filing
- 2005-08-30 DE DE502005007106T patent/DE502005007106D1/de active Active
- 2005-08-30 BR BRPI0514833-2A patent/BRPI0514833A/pt not_active IP Right Cessation
- 2005-08-30 MX MX2007002470A patent/MX2007002470A/es not_active Application Discontinuation
- 2005-08-30 ES ES05776232T patent/ES2324049T3/es active Active
- 2005-09-01 AR ARP050103664A patent/AR050551A1/es not_active Application Discontinuation
- 2005-09-01 GT GT200500238A patent/GT200500238A/es unknown
- 2005-09-02 SV SV2005002218A patent/SV2006002218A/es not_active Application Discontinuation
- 2005-09-02 TW TW094130123A patent/TW200621765A/zh unknown
- 2005-09-02 PE PE2005001012A patent/PE20060589A1/es not_active Application Discontinuation
- 2005-09-05 UY UY29099A patent/UY29099A1/es not_active Application Discontinuation
-
2007
- 2007-03-01 ZA ZA200701820A patent/ZA200701820B/xx unknown
- 2007-03-01 IL IL181670A patent/IL181670A0/en unknown
- 2007-03-02 EC EC2007007296A patent/ECSP077296A/es unknown
- 2007-03-13 NO NO20071343A patent/NO20071343L/no not_active Application Discontinuation
- 2007-03-23 MA MA29769A patent/MA28869B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080269300A1 (en) | 2008-10-30 |
| MA28869B1 (fr) | 2007-09-03 |
| UY29099A1 (es) | 2006-04-28 |
| NO20071343L (no) | 2007-05-30 |
| MX2007002470A (es) | 2009-02-12 |
| CA2578596A1 (en) | 2006-03-16 |
| TW200621765A (en) | 2006-07-01 |
| WO2006027142A1 (de) | 2006-03-16 |
| IL181670A0 (en) | 2007-07-04 |
| ATE428710T1 (de) | 2009-05-15 |
| US8691850B2 (en) | 2014-04-08 |
| GT200500238A (es) | 2006-04-10 |
| SV2006002218A (es) | 2006-10-04 |
| CA2578596C (en) | 2012-10-23 |
| ES2324049T3 (es) | 2009-07-29 |
| KR20070057235A (ko) | 2007-06-04 |
| EP1812430B1 (de) | 2009-04-15 |
| CN101056875A (zh) | 2007-10-17 |
| EP1812430A1 (de) | 2007-08-01 |
| PE20060589A1 (es) | 2006-08-12 |
| AU2005281941A1 (en) | 2006-03-16 |
| ECSP077296A (es) | 2007-04-26 |
| JP4999691B2 (ja) | 2012-08-15 |
| DE102004042607A1 (de) | 2006-03-09 |
| ZA200701820B (en) | 2008-08-27 |
| BRPI0514833A (pt) | 2008-06-24 |
| DE502005007106D1 (de) | 2009-05-28 |
| JP2008511614A (ja) | 2008-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR050551A1 (es) | Fenilaminotiazoles sustituidos y su uso | |
| PE20131464A1 (es) | Derivados de quinazolin-4 (3h)-ona utilizados como inhibidores de pi3 cinasa | |
| ECSP099781A (es) | Novedosos compuestos que son inhibidores de erk | |
| MX2020003552A (es) | Formas cristalinas. | |
| NO20053775L (no) | Diazepinoindol derivater som kinaseinhibitorer. | |
| AR067646A1 (es) | Ariloxazoles sustituidos y su uso | |
| ECSP067100A (es) | Preparación enantioselectiva del derivado de quinolina | |
| DOP2005000011A (es) | Derivados de indazol como inhibidores de la lipasa sensible a hormonas | |
| ECSP109953A (es) | Derivados de piridazinona | |
| ECSP088598A (es) | Derivados de piridazinona | |
| UY29199A1 (es) | Derivados tiazol, composiciones que los contienen, procedimientos de preparación y aplicaciones | |
| UY27714A1 (es) | 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos. | |
| ECSP088550A (es) | Nuevos compuestos que son inhibidores de erk | |
| UY27742A1 (es) | Derivados de quinazolina | |
| ECSP066958A (es) | Compuestos de morfolina | |
| CY1109656T1 (el) | Υποκατεστημενα παραγωγα μορφολινης και θειομορφολινης | |
| DE60322359D1 (de) | Imidazopyridinderivate als kinaseinhibitoren | |
| AR088808A2 (es) | Derivados de 2h-piridazin-3-ona, composiciones farmaceuticas que los contienen y un proceso para la preparacion de dichos derivados y el uso de dichos derivados para la preparacion de una composicion farmaceutica | |
| AR053554A1 (es) | Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos | |
| AR044078A1 (es) | Dihidroquinazolinas sustituidas | |
| PE20121471A1 (es) | Derivados de sulfonamida heterociclicos utiles como inhibidores de mek | |
| PE20140970A1 (es) | Derivados de 6-ciclobutil-1,5-dihidro-pirazol [3,4-d) pirimidin-4-ona y su uso como inhibidores de pde9a | |
| AR053347A1 (es) | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos | |
| AR078613A1 (es) | Derivados de sulfoxidos benzooxazolicos y benzotriazolicos inhibidores de autotaxinas, medicamentos que los contienen y uso de los mismos para el tratamiento de tumores. | |
| AR059320A1 (es) | Composicion antitumorial que comprende un inhibidor de quinasas dependientes de ciclinas y un anticuerpo que inhibe un factor de crecimiento y/o un compuesto antimitotico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |