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AR040456A1 - Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana - Google Patents

Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana

Info

Publication number
AR040456A1
AR040456A1 AR20030102227A ARP030102227A AR040456A1 AR 040456 A1 AR040456 A1 AR 040456A1 AR 20030102227 A AR20030102227 A AR 20030102227A AR P030102227 A ARP030102227 A AR P030102227A AR 040456 A1 AR040456 A1 AR 040456A1
Authority
AR
Argentina
Prior art keywords
reverse transcriptase
piridine
disposals
inhibitors
oxides
Prior art date
Application number
AR20030102227A
Other languages
English (en)
Inventor
Haishene Wang
James D Rodgers
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR040456A1 publication Critical patent/AR040456A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de piridina N-óxido de la fórmula (1) o una forma estereoisomérica o mezcla de las formas estereoisóméricas o una forma de la sal del mismo aceptable farmacéuticamente, en donde B es seleccionado de fenilo substituido con 1-3 X y un sistema heterocíclico de 5-6 miembros que contiene 1-4 heteroátomos seleccionados de N, O y S, substituidos en 1-3 X; R1, en cada presentación, es seleccionado individualmente de F, Cl, Br, I, CN y alquilo C1-4, alcoxi C1-3; n es seleccionado de 1, 2, 3 y 4; X es seleccionado de CN, F, Cl, Br e I; Y es seleccionado de -CH2, -NH-, y -O-; y Z es seleccionado de F, Cl, Br, CN y alquilo C1-4. Composición farmacéutica que comprende dicho compuesto de fórmula (1) junto con un portador farmacéuticamente aceptable y uso del compuesto para preparar dicha composición de aplicación en el tratamiento de una infección por VIH mediante la inhibición de la transcriptasa inversa del virus.
AR20030102227A 2002-06-27 2003-06-23 Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana AR040456A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39209202P 2002-06-27 2002-06-27

Publications (1)

Publication Number Publication Date
AR040456A1 true AR040456A1 (es) 2005-04-06

Family

ID=30000810

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102227A AR040456A1 (es) 2002-06-27 2003-06-23 Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana

Country Status (7)

Country Link
US (1) US6809109B2 (es)
EP (1) EP1523476A2 (es)
AR (1) AR040456A1 (es)
AU (1) AU2003243765A1 (es)
PE (1) PE20040610A1 (es)
TW (1) TW200409629A (es)
WO (1) WO2004002410A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2533258T3 (es) 2005-02-18 2015-04-08 Janssen Sciences Ireland Uc Derivados de óxido de 2-(4-cianofenilamino)pirimidina que inhiben el VIH
MY145343A (en) * 2005-03-25 2012-01-31 Glaxo Group Ltd Novel compounds
US7473683B2 (en) 2005-09-14 2009-01-06 The Board Of Trustees Of The Leland Stanford Junior University Nonpolar thymidine analogs
US8666445B2 (en) * 2005-10-25 2014-03-04 Kyocera Corporation Apparatus, system, and method for transmission antenna switching in a portable communication device
US8501763B2 (en) * 2007-03-16 2013-08-06 The Scripps Research Institute Inhibitors of focal adhesion kinase
EP2464642A4 (en) * 2009-08-12 2013-01-09 Poniard Pharmaceuticals Inc PROCESS FOR PROMOTING APOPTOSIS AND INHIBITION OF METASTASIS
AU2011276552B2 (en) 2010-06-29 2015-09-03 Verastem, Inc. Oral formulation of kinase inhibitors
CA2803005A1 (en) * 2010-06-30 2012-01-26 Poniard Pharmaceuticals, Inc. Synthesis and use of kinase inhibitors
US10557015B2 (en) 2014-06-24 2020-02-11 Byk-Chemie Gmbh Epoxy resin-epoxy curing systems with a latent thickening tendency
EP3180325B1 (en) * 2014-07-28 2019-03-20 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
IL310338A (en) * 2021-08-31 2024-03-01 Eisai R&D Man Co Ltd Production method for a synthetic intermediate of a monocyclic pyridine derivative

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US340A (en) * 1837-07-31 Cooking-stove
US3470172A (en) 1967-03-02 1969-09-30 Mobil Oil Corp Process for producing certain amino substituted nitro pyridines
US3495969A (en) 1967-09-25 1970-02-17 Mobil Oil Corp Substituted nitropyridines as herbicides
EP0264883A3 (en) 1986-10-21 1990-04-04 Banyu Pharmaceutical Co., Ltd. Substituted pyridine derivatives
CA1339423C (en) 1988-09-14 1997-09-02 Yuji Ono Pyridine compounds and pharmaceutical use thereof
DE3905238A1 (de) 1989-02-21 1990-08-23 Basf Ag 2-anilino-cyanopyridine und diese enthaltende fungizide
JPH03206450A (ja) 1990-01-09 1991-09-09 Fuji Photo Film Co Ltd 新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料及びその処理方法
DE4029772A1 (de) 1990-09-20 1992-03-26 Basf Ag 2-anilino-cyanopyridine und ihre verwendung zur bekaempfung von schaedlingen
WO1993004047A1 (en) 1991-08-16 1993-03-04 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
IL102764A0 (en) 1991-08-16 1993-01-31 Merck & Co Inc Quinazoline derivatives,and pharmaceutical compositions containing them
EP0533130A1 (de) 1991-09-19 1993-03-24 Hoechst Aktiengesellschaft 2-Hydroxymethylpyridine, die entsprechenden Pyridin-N-oxide und ihre Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung
US5663169A (en) 1992-08-07 1997-09-02 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
SK47096A3 (en) 1993-10-12 1996-10-02 Du Pont Merck Pharma 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
CN1142817A (zh) 1993-10-12 1997-02-12 杜邦麦克制药有限公司 1n-烷基-n-芳基嘧啶胺及其衍生物
WO1995012583A1 (en) 1993-11-05 1995-05-11 Merck & Co., Inc. New quinazolines as inhibitors of hiv reverse transcriptase
US5434152A (en) 1993-11-08 1995-07-18 Merck & Co., Inc. Asymmetric synthesis of (S)-(-)-6-chloro-4- cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone
JPH07247214A (ja) 1994-03-09 1995-09-26 Yoshitomi Pharmaceut Ind Ltd β−アミロイド生成および／または沈着の抑制剤
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
CA2214685C (en) 1995-03-10 2008-05-20 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
DE69600385T2 (de) 1995-03-28 1998-12-17 Sumitomo Chemical Co., Ltd., Osaka Verfahren zur Herstellung von Aminonitropyridinen
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
DE69717474T2 (de) 1996-09-12 2003-06-26 Schering Ag Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
US5874430A (en) 1996-10-02 1999-02-23 Dupont Pharmaceuticals Company 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
US6004985A (en) 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
AU6251799A (en) 1998-09-16 2000-04-03 Dow Agrosciences Llc 2-methoxyimino -2-(pyridinyloxymethyl) phenyl acetamides useful as fungicides
CA2350801C (en) 1998-11-10 2008-05-20 Janssen Pharmaceutica N.V. Hiv replication inhibiting pyrimidines
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
EP1040831A3 (en) 1999-04-02 2003-05-02 Pfizer Products Inc. Use of corticotropin releasing factor (CRF) antagonists to prevent sudden death
US6387894B1 (en) 1999-06-11 2002-05-14 Pfizer Inc. Use of CRF antagonists and renin-angiotensin system inhibitors
JP2001089452A (ja) 1999-09-22 2001-04-03 Sankyo Co Ltd ピリミジン誘導体
US6458789B1 (en) * 1999-09-29 2002-10-01 Lion Bioscience Ag 2-aminopyridine derivatives and combinatorial libraries thereof
US6525067B1 (en) 1999-11-23 2003-02-25 Pfizer Inc Substituted heterocyclic derivatives
HUP0204272A3 (en) 2000-01-18 2005-03-29 Pfizer Prod Inc Corticotropin releasing factor antagonists, pharmaceutical compositions containing them and their use
US6800651B2 (en) 2000-02-03 2004-10-05 Eli Lilly And Company Potentiators of glutamate receptors
ES2240449T3 (es) 2000-02-25 2005-10-16 F. Hoffmann-La Roche Ag Moduladores receptores de adenosina.

Also Published As

Publication number Publication date
US6809109B2 (en) 2004-10-26
TW200409629A (en) 2004-06-16
WO2004002410A2 (en) 2004-01-08
PE20040610A1 (es) 2004-09-09
WO2004002410A3 (en) 2004-08-05
AU2003243765A1 (en) 2004-01-19
US20040019047A1 (en) 2004-01-29
AU2003243765A8 (en) 2004-01-19
EP1523476A2 (en) 2005-04-20

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Legal Events

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FA Abandonment or withdrawal