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AR035695A1 - Compuestos inhibidores de metaloproteinasa, composicion farmaceutica, metodo de tratamiento, y uso de estos compuestos para la preparacion de medicamentos - Google Patents

Compuestos inhibidores de metaloproteinasa, composicion farmaceutica, metodo de tratamiento, y uso de estos compuestos para la preparacion de medicamentos

Info

Publication number
AR035695A1
AR035695A1 ARP020100943A ARP020100943A AR035695A1 AR 035695 A1 AR035695 A1 AR 035695A1 AR P020100943 A ARP020100943 A AR P020100943A AR P020100943 A ARP020100943 A AR P020100943A AR 035695 A1 AR035695 A1 AR 035695A1
Authority
AR
Argentina
Prior art keywords
alkyl
heteroaryl
ring
aryl
heteroalkyl
Prior art date
Application number
ARP020100943A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR035695A1 publication Critical patent/AR035695A1/es

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/04—Ortho-condensed systems

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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
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  • Pain & Pain Management (AREA)
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  • Vascular Medicine (AREA)
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  • Reproductive Health (AREA)

Abstract

Un compuesto con la fórmula (1) o una sal farmacéuticamente aceptable o un éster hidrolizable in vivo del mismo, en la cual: X se selecciona entre NR1, O y S; Y1 e Y2 se seleccionan independientemente entre O y S; Z se selecciona entre SO y SO2; m es 1 ó 2; A se selecciona entre un enlace directo, alquilo C1-6, haloalquilo C1-6 o heteroalquilo C1-6 que contienen un heterogrupo que se selecciona entre N, O, S, SO ó SO2 o que contienen dos heterogrupos seleccionados entre N, O, S, SO y SO2 y están separados por al menos dos átomos de carbono; R1 se selecciona entre H, alquilo C1-3 y haloalquilo; cada R2 y R3 se seleccionan independientemente entre H, halógen, alquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, alquilarilo, alquilheteroarilo, heteroalquilarilo, heteroalquilo-heteroarilo, arilo-alquilo, arilo-heteroalquilo, heteroariloalquilo, heteroarilo-heteroalquilo, arilo-arilo, arilo-heteroarilo, heteroarilo-arilo, heteroarilo-heteroarilo, cicloalquilo-alquilo, heterocicloalquilo-alquilo, alquilo-cicloalquilo y alquilo-heterocicloalquilo; cada R4 se selecciona independientemente entre H, halógeno, alquilo C1-3 o haloalquilo; cada uno de los radicales R2 y R3 pueden estar opcional e independientemente sustituidos con uno o más grupos seleccionados entre alquilo, heteroalquilo, arilo, heteroarilo, halo, haloalquilo, hidroxi, alcoxi, haloalcoxi, tiol, alquiltiol, ariltiol, alquilsulfon, haloalquilsulfon, arilsulfon, aminosulfon, N-alquiloaminosulfon, N,N-dialquilaminosulfon, arilaminosulfon, amino, N-alquilamino, N,N-dialquilamino, amida, N-alquilamida, N,N-dialquilamida, ciano, sulfonamina, alquilsulfonamina, arilsulfonamina, amidina, N-aminosulfon-amidina, guanidina, N-ciano-guanidina, tioguanidina, 2-nitro-eten-1,1-diamina, carboxi, alquilcarboxi, nitro o carbamato; opcionalmente R2 y R3 pueden unirse para formar un anillo que comprende hasta 7 átomos en el anillo, o bien R2 y R4 pueden unirse para formar un anillo que comprende hasta 7 átomos en el anillo, o bien R3 y R4 pueden unirse para formar un anillo que comprende hasta 7 átomos en el anillo; y R5 es un grupo monocíclico, bicíclico o tricíclico que comprende 1, 2 ó 3 estructuras de anillo cada una de las cuales con hasta 7 átomos en el anillo, independientemente seleccionadas entre cicloalquilo, arilo, heterocicloalquilo o heteroarilo, estando cada estructura del anillo opcional e independientemente sustituida con uno o más sustituyentes seleccionados de modo independiente entre halógeno, hidroxi, alquilo, alcoxi, haloalcoxi, amina, N-alquilamina, N,N-dialquilamina, alquilsulfonamina, alquilcarboxiamina, ciano, nitro, tiol, alquiltiol, alquilsulfonilo, haloalquilsulfonilo, alquilaminosulfonilo, carboxilato, alquilcarboxilato, aminocarboxi, N-alquilamino-carboxi, N,N-dialquilamino-carboxi, en los cuales cualquier radical alquilo dentro de cualquier sustituyente puede en sí misma estar opcionalmente sustituido con uno o más grupos que se seleccionan entre halógeno, hidroxi, alcoxi, haloalcoxi, amina, N-alquilamina, N,N-dialquilamina, N-alquilsulfonamina, N-alquilcarboxamina, ciano, nitro, tiol, alquiltiol, alquilsulfonilo, N-alquilaminosulfonilo, carboxilato, alquilcarboxi, aminocarboxi, N-alquilaminocarboxi, N,N-dialquilaminocarboxi y carbamato; cuando R5 es un grupo bicíclico o tricíclico, cada estructura de anillo está unida a la siguiente estructura de anillo por un enlace directo, -O-, alquilo C1-6, haloalquilo C1-6, heteroalquilo C1-6, alquenilo C1-6, alquinilo C1-6, sulfona, CO, NCO, CON, NH, S, C(OH) o bien está fusionada a la siguiente estructura de anillo; composición farmacéutica, método de tratamiento, y uso de estos compuestos para la preparación de medicamentos.
ARP020100943A 2001-03-15 2002-03-15 Compuestos inhibidores de metaloproteinasa, composicion farmaceutica, metodo de tratamiento, y uso de estos compuestos para la preparacion de medicamentos AR035695A1 (es)

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