AR020551A2 - Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos. - Google Patents
Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos.Info
- Publication number
- AR020551A2 AR020551A2 ARP990106064A ARP990106064A AR020551A2 AR 020551 A2 AR020551 A2 AR 020551A2 AR P990106064 A ARP990106064 A AR P990106064A AR P990106064 A ARP990106064 A AR P990106064A AR 020551 A2 AR020551 A2 AR 020551A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- groups
- optionally substituted
- group
- halogen atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un compuesto de formula 1 o una de sus sales farmacéuticamente aceptables, en la que : R1 es un grupo alquilo, alquenilo, alquinilo, alcoxialquilo oalquiltioalquilo C3-8 alfa ramificado, pudiendo estar cualquiera de los cuales opcionalmente sustituído por uno omás grupos hidroxilo; un grupocicloalquilalquilo C5-8 en el que el grupo alquilo es un grupo alquilo C2-5 alfa ramificado; un grupo cicloalquilo C3-8 o cicloalquenilo C5-8, cualquiera de loscuales puede estar opcionalmente sustituido por metilo o uno o más hidroxilo o uno o más grupos alquilo C1-4 o átomos de halogeno; o un anillo heterocíclicoque contiene oxígeno o azufre de 3 a 6 eslabones que puede ser saturado o total, o parcialmente insaturado y que puede estar opcionalmente sustituido por unoo más grupos alquilo C1-4 átomos de halogeno; o R1 es fenilo que puede estar opcionalmente sustituido con al menos un sustituyente seleccionado de gruposalquilo C1-4, alcoxi C1-4 y (alquil C1-4)tio, átomos de halogeno, grupos hidroxilo,trifluorometilo y ciano; o R1 puede ser un grupo con una formula (a) comose muestra a continuacion 2, en la que X es O, S, o -CH2-, a, b, c y d son cada uno independientemente, 0-2 y a + b + c + d < = 5; o R1 es CH2R24, donde R24es H, alquilo C1-6,alquenilo C2-6, alquinilo C2-6, alcoxialquilo o alquiltioalquilo, que contienen C1-6 en cada uno de los grupos alquilo o alcoxi, pudiendoestar cualquiera de dichos grupos alquilo, alcoxi, alquenilo, o alquinilo sustituido por uno o más grupos hidroxilo o por uno o más átomos de halogeno; o uncicloalquilo C3-6 o cicloalquenilo C3-6, cualquiera de los cuales puede estar opcionalmente sustituido por metilo o uno o más grupos alquilo C1-4 o átomos dehalogeno; o un anillo heterocíclico que contieneoxígeno o azufre de 3 a 6 eslabones que puede ser saturado o total o parcialmente insaturado y que puedeestar opcionalmente sustituido por uno o más grupos alquilo C1-4 o átomos de halogeno; o un grupo de formula SR23 donde R23 es alquilo C1-6, alquenilo C2-6,alquinilo C2-6, cicloalquilo C3-6, cicloalquenilo C3-6, fenilo o fenilo sustituido, donde el sustituyente es alquilo C1-4, alcoxi C1-4 o halogeno, o un anillo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7034398P | 1998-01-02 | 1998-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020551A2 true AR020551A2 (es) | 2002-05-15 |
Family
ID=22094723
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106717A AR014948A1 (es) | 1998-01-02 | 1998-12-29 | Compuestos macrolidos, composiciones, su uso para la manufactura de medicamentos y metodo para prepararlos. |
| ARP990106063A AR020851A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos |
| ARP990106064A AR020551A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos. |
| ARP990106062A AR019787A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, su uso en la preparacion de medicamentos, composiciones y metodo para la preparacion de los mismos |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106717A AR014948A1 (es) | 1998-01-02 | 1998-12-29 | Compuestos macrolidos, composiciones, su uso para la manufactura de medicamentos y metodo para prepararlos. |
| ARP990106063A AR020851A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106062A AR019787A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, su uso en la preparacion de medicamentos, composiciones y metodo para la preparacion de los mismos |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6472371B1 (es) |
| EP (1) | EP1044207A1 (es) |
| JP (1) | JP2002500230A (es) |
| KR (1) | KR100352809B1 (es) |
| CN (1) | CN1284081A (es) |
| AP (1) | AP9801420A0 (es) |
| AR (4) | AR014948A1 (es) |
| AU (1) | AU756409B2 (es) |
| BG (1) | BG104644A (es) |
| BR (1) | BR9814601A (es) |
| CA (1) | CA2316919C (es) |
| CO (1) | CO4970821A1 (es) |
| CZ (1) | CZ20002458A3 (es) |
| DZ (1) | DZ2698A1 (es) |
| EA (1) | EA200000594A1 (es) |
| GT (1) | GT199800206A (es) |
| HR (1) | HRP20000442A2 (es) |
| HU (1) | HUP0100420A3 (es) |
| IL (1) | IL137024A0 (es) |
| IS (1) | IS5528A (es) |
| MA (1) | MA24729A1 (es) |
| NO (1) | NO20003347L (es) |
| NZ (1) | NZ504986A (es) |
| OA (1) | OA11438A (es) |
| PA (1) | PA8465301A1 (es) |
| PE (1) | PE20000049A1 (es) |
| PL (1) | PL341642A1 (es) |
| SK (1) | SK9782000A3 (es) |
| TN (1) | TNSN98238A1 (es) |
| TW (1) | TW520374B (es) |
| UY (2) | UY25330A1 (es) |
| WO (1) | WO1999035156A1 (es) |
| YU (1) | YU41500A (es) |
| ZA (1) | ZA9811939B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP9801420A0 (en) | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| EP1437360A3 (en) * | 1998-08-19 | 2005-04-06 | Pfizer Products Inc. | C11 Carbamates of macrolide antibacterials |
| US6043227A (en) * | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
| EP1754700A3 (en) | 1999-01-27 | 2007-05-09 | Kosan Biosciences, Inc. | Synthesis of oligoketides |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| IL145976A0 (en) | 1999-04-16 | 2002-07-25 | Ortho Mcneil Pharm Inc | Ketolide antibacterials |
| WO2000071557A1 (en) | 1999-05-24 | 2000-11-30 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
| KR20040088521A (ko) * | 2002-02-26 | 2004-10-16 | 메이지 세이카 가이샤 리미티드 | 신규 １５원환 아잘라이드 및 신규 １６원환 디아잘라이드 유도체와 그의 제조법 |
| NZ553777A (en) | 2004-09-23 | 2010-11-26 | Schering Plough Ltd | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives |
| MX2007006072A (es) * | 2004-11-19 | 2007-07-11 | Schering Plough Ltd | Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo. |
| AP2007004026A0 (en) | 2004-12-21 | 2007-06-30 | Pfizer Prod Inc | Macrolides |
| AR054380A1 (es) * | 2005-06-09 | 2007-06-20 | Schering Plough Ltd | Control de parasitos en animales con derivados de n- ((feniloxi) fenil) -1,1,1-trifluorometansulfonamida y de n-(fenilsulfanil) fenil) -1,1,1-trifluorometansulfonamida |
| US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| US20070238700A1 (en) * | 2006-04-10 | 2007-10-11 | Winzenberg Kevin N | N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites |
| CA2672586A1 (en) * | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of florfenicol and its analogs |
| US8044230B2 (en) * | 2006-12-13 | 2011-10-25 | Intervet Inc. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| CA2685072C (en) | 2007-06-27 | 2017-08-01 | E. I. Du Pont De Nemours And Company | Animal pest control method |
| US20090131343A1 (en) * | 2007-11-15 | 2009-05-21 | Ly Tam Phan | Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases |
| TWI401023B (zh) | 2008-02-06 | 2013-07-11 | Du Pont | 中離子農藥 |
| US8314252B2 (en) * | 2008-07-30 | 2012-11-20 | Intervet Inc. | Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol |
| BR112012002524A2 (pt) | 2009-08-05 | 2019-09-24 | Du Pont | "composto de fórmula, composição, composição para proteger um animal de uma praga parasítica de invertebrados, métodos para controlar uma praga invertebrada e semente tratada" |
| UA107804C2 (en) | 2009-08-05 | 2015-02-25 | Du Pont | Mixtures of pesticides mezoionnyh |
| UA110924C2 (uk) | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
| WO2011017334A2 (en) | 2009-08-05 | 2011-02-10 | E. I. Du Pont De Nemours And Company | Mesoionic pesticides |
| DK2576523T3 (en) | 2010-05-27 | 2016-04-18 | Du Pont | A crystalline form of 4- [5- [3-chloro-5- (trifluoromethyl) phenyl] -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [2-oxo-2 - [( 2,2,2-trifluoroethyl) amino] ethyl] - 1-naphthalenecarboxamide |
| WO2012087630A1 (en) | 2010-12-20 | 2012-06-28 | E.I. Du Pont De Nemours And Company | Pyridine and pyrimidine compounds for controlling invertebrate |
| KR20140004187A (ko) * | 2011-01-31 | 2014-01-10 | 메이지 세이카 파루마 가부시키가이샤 | 신규 마크로라이드 유도체 |
| US20140113934A1 (en) | 2011-06-20 | 2014-04-24 | E I Du Pont De Nemours And Company | Heterocyclic compounds for treating helminth infections |
| CN102260306B (zh) * | 2011-07-22 | 2012-07-18 | 山东鲁抗舍里乐药业有限公司 | 一种制备泰拉霉素的方法 |
| SG11201402664VA (en) | 2011-11-28 | 2014-06-27 | Du Pont | N- (4 -quinolinylmethyl) sulfonamide derivatives and their use as anthelmintics |
| WO2013158422A1 (en) | 2012-04-17 | 2013-10-24 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for controlling invertebrate pests |
| WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
| CN105669798B (zh) * | 2013-08-23 | 2019-07-26 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
| CN103965273B (zh) * | 2013-08-23 | 2016-05-25 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652537A (en) * | 1969-11-21 | 1972-03-28 | Lilly Co Eli | Epierythromycylamine and epierythromycyl b amine |
| US3923784A (en) * | 1973-09-10 | 1975-12-02 | Hoffmann La Roche | Erythromycin a derivatives |
| YU43116B (en) * | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
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| US4585759A (en) * | 1985-01-22 | 1986-04-29 | Pfizer Inc. | Antibacterial derivatives of a neutral macrolide |
| DE3860503D1 (de) * | 1987-09-03 | 1990-10-04 | Pliva Pharm & Chem Works | 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung. |
| US5141926A (en) * | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| US5824513A (en) * | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
| WO1993013663A1 (en) | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
| US5985844A (en) * | 1992-03-26 | 1999-11-16 | Merck & Co., Inc. | Homoerythromycin A derivatives modified at the 4"-and 8A-positions |
| CA2065218A1 (en) | 1991-04-11 | 1992-10-12 | Robert R. Wilkening | Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives |
| US5523399A (en) * | 1991-12-27 | 1996-06-04 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide derivatives |
| FR2691464B1 (fr) * | 1992-05-21 | 1995-06-02 | Roussel Uclaf | Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments. |
| US5332807A (en) * | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
| US5441939A (en) * | 1994-03-04 | 1995-08-15 | Pfizer Inc. | 3"-desmethoxy derivatives of erythromycin and azithromycin |
| US6271255B1 (en) * | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| US6162794A (en) * | 1997-05-09 | 2000-12-19 | Pfizer Inc. | Erythromycin derivatives |
| US6407074B1 (en) * | 1997-06-11 | 2002-06-18 | Pfizer Inc | C-4″-substituted macrolide derivatives |
| HN1998000074A (es) * | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | Derivados de macrolidos c-4 sustituidos |
| US20020025937A1 (en) * | 2000-03-20 | 2002-02-28 | Yong-Jin Wu | 9-oxime erythromycin derivatives |
| HN1998000086A (es) * | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
| AU7961498A (en) | 1997-06-26 | 1999-01-19 | Merck & Co., Inc. | 9a-azalides, compositions containing such compounds and methods of treatment |
| US6339063B1 (en) * | 1997-09-10 | 2002-01-15 | Merck & Co., Inc. | 9a-azalides as veterinary antimicrobial agents |
| PA8461401A1 (es) * | 1997-10-29 | 2000-05-24 | Pfizer Prod Inc | Derivados de eritromicina triciclicos |
| HN1998000159A (es) * | 1997-10-29 | 1999-02-09 | Monsanto Co | Derivados de 9- amino - 3 ceto eritromicina |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| AP9801420A0 (en) | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| DE69919769T2 (de) * | 1998-03-03 | 2005-01-27 | Pfizer Products Inc., Groton | 3,6-Ketal-Makrolidantibiotika |
| US6248719B1 (en) * | 1998-06-03 | 2001-06-19 | Pfizer Inc | Tricyclic 3-keto derivatives of 6-O-methylerthromycin |
| US6043227A (en) * | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
| US6100240A (en) * | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
| EP1124837A2 (en) * | 1998-11-03 | 2001-08-22 | Pfizer Products Inc. | Novel macrolide antibiotics |
| UA70972C2 (uk) * | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
| WO2000071557A1 (en) | 1999-05-24 | 2000-11-30 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
| EP1101769A3 (en) * | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Nitrogen containing erythromycin derivatives |
| WO2003014136A1 (en) | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
-
1998
- 1998-12-17 AP APAP/P/1998/001420A patent/AP9801420A0/en unknown
- 1998-12-21 PL PL98341642A patent/PL341642A1/xx unknown
- 1998-12-21 AU AU14447/99A patent/AU756409B2/en not_active Ceased
- 1998-12-21 CZ CZ20002458A patent/CZ20002458A3/cs unknown
- 1998-12-21 US US09/554,988 patent/US6472371B1/en not_active Expired - Fee Related
- 1998-12-21 HU HU0100420A patent/HUP0100420A3/hu unknown
- 1998-12-21 EP EP98958384A patent/EP1044207A1/en not_active Withdrawn
- 1998-12-21 CA CA002316919A patent/CA2316919C/en not_active Expired - Fee Related
- 1998-12-21 BR BR9814601-7A patent/BR9814601A/pt not_active IP Right Cessation
- 1998-12-21 YU YU41500A patent/YU41500A/sh unknown
- 1998-12-21 SK SK978-2000A patent/SK9782000A3/sk unknown
- 1998-12-21 IL IL13702498A patent/IL137024A0/xx unknown
- 1998-12-21 WO PCT/IB1998/002099 patent/WO1999035156A1/en not_active Application Discontinuation
- 1998-12-21 CN CN98813253A patent/CN1284081A/zh active Pending
- 1998-12-21 NZ NZ504986A patent/NZ504986A/xx unknown
- 1998-12-21 JP JP2000527552A patent/JP2002500230A/ja active Pending
- 1998-12-21 KR KR1020007007313A patent/KR100352809B1/ko not_active IP Right Cessation
- 1998-12-22 EA EA200000594A patent/EA200000594A1/ru unknown
- 1998-12-23 TW TW087121542A patent/TW520374B/zh not_active IP Right Cessation
- 1998-12-23 PA PA19988465301A patent/PA8465301A1/es unknown
- 1998-12-28 PE PE1998001287A patent/PE20000049A1/es not_active Application Discontinuation
- 1998-12-29 GT GT199800206A patent/GT199800206A/es unknown
- 1998-12-29 AR ARP980106717A patent/AR014948A1/es not_active Application Discontinuation
- 1998-12-30 TN TNTNSN98238A patent/TNSN98238A1/fr unknown
- 1998-12-30 UY UY25330A patent/UY25330A1/es not_active Application Discontinuation
- 1998-12-30 CO CO98077585A patent/CO4970821A1/es unknown
- 1998-12-30 DZ DZ980308A patent/DZ2698A1/xx active
- 1998-12-30 MA MA25407A patent/MA24729A1/fr unknown
- 1998-12-30 ZA ZA9811939A patent/ZA9811939B/xx unknown
-
1999
- 1999-06-18 UY UY25574A patent/UY25574A1/es not_active Application Discontinuation
- 1999-11-29 AR ARP990106063A patent/AR020851A2/es not_active Application Discontinuation
- 1999-11-29 AR ARP990106064A patent/AR020551A2/es not_active Application Discontinuation
- 1999-11-29 AR ARP990106062A patent/AR019787A2/es not_active Application Discontinuation
-
2000
- 2000-06-09 IS IS5528A patent/IS5528A/is unknown
- 2000-06-27 NO NO20003347A patent/NO20003347L/no unknown
- 2000-06-30 OA OA1200000192A patent/OA11438A/en unknown
- 2000-06-30 HR HR20000442A patent/HRP20000442A2/hr not_active Application Discontinuation
- 2000-07-28 BG BG104644A patent/BG104644A/xx unknown
-
2002
- 2002-07-30 US US10/209,682 patent/US7015203B2/en not_active Expired - Fee Related
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