AR019415A1 - Derivados de bifenilo, un procedimiento para su preparacion, su empleo en la preparacion de medicamentos, las composiciones farmaceuticas que los contieneny un procedimiento para preparar estas composiciones farmaceuticas - Google Patents
Derivados de bifenilo, un procedimiento para su preparacion, su empleo en la preparacion de medicamentos, las composiciones farmaceuticas que los contieneny un procedimiento para preparar estas composiciones farmaceuticasInfo
- Publication number
- AR019415A1 AR019415A1 ARP990103510A ARP990103510A AR019415A1 AR 019415 A1 AR019415 A1 AR 019415A1 AR P990103510 A ARP990103510 A AR P990103510A AR P990103510 A ARP990103510 A AR P990103510A AR 019415 A1 AR019415 A1 AR 019415A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- procedure
- preparation
- piperidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Derivados de bifenilo de formula (1) en donde R representa -C(=NH)-NH2, -C(=NH)-NHA3, -C(=NH)-NHAc, -C(=NH) -NHSO2CH3, R2, -CO-NH-Z-R3 o -CO-R1, Xrepresenta -CONH-, SO2NH-, -NHCO- o -NHSO2, Y representa CH o N, A1 representa H, alquilo de 1 a 6 átomos de C en el cual 1 a 7 átomos de H pueden estarreeemplazados por F, SO2CH3, o SO2CF3, A2 representa H o alquilo de 1 a 6 átomos de C, A3, A5 representan independientemente alquilo C1-6, A6, A7representan independientemente H o (CH2)pCH3, Q representa H o OA1, R representa 4-A5-piperazin-1-ilo, 4-A5-homopiperazinilo, 1-pirrolidinilo monosustituidocon R4 o Z-R4, 1 piperidinilo monosustituido con R4 o Z-R4, N-A5-pirrolidinil-amino, N-A5-piperidinil-amino, N-A5-pirrolidinil-Z-amino, N-A5-piperidinil-Z-amino, -N(A6) (ZR3) o NA6A7, R2 representa 5-metil-1, 3, 4 -oxadiazol-2-ilo o 5- metil-1,2,4-oxadiazol-3-ilo, R3, R4 representan independientemente NHA5,N(A5)2, 4-morfolinilo, 1-pirrolidinilo o 1-piperidinilo, Z representa alquileno de 1 a 6 átomos de C, n es 0 o 1, p es 0, 1 o 2, con la condicion de que cuandoY representa N, X=CONH- y n=1, entonces R no es R2 o R no es -CONA6A7, incluyendo los racematos, los enantiomeros, las sales aceptables desde el punto de vistafisiologico y los solvatos de estos compuestos. Un procedimiento para preparar los compuestos de formula I, sus sales y sus solvatos, en el cual a) se hacereaccionar un compuesto de formula II en donde L representa Cl, Br, I o un grupo OH transformado funcionalmente en ungrupo reactivo, y R y A3 tienen lossignificados indicados más arriba, con un derivado del ácido boronico de formula III en donde X, Y, A1, A2 Q y n tienen los significados indicados más arriba ob) se hace reaccionar un compuesto de formula IV en donde R y A3 y L tienen los significados indicados, X representa CO o SO2, con un compuesto de formula Ven donde Y, A1, A2 y n tienen los significados indicados o c) para preparar un compuesto de formula I en donde R representa -CO-NH--Z-R3 o -CO-R1 se hacereaccionar un compuesto de formula VI en donde L representa Cl, Br, I o un grupo OH libre o transformado funcionalmente en un grupo reactivo, y X, Y, A1,A2, A3
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98113488 | 1998-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019415A1 true AR019415A1 (es) | 2002-02-20 |
Family
ID=8232308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990103510A AR019415A1 (es) | 1998-07-20 | 1999-07-16 | Derivados de bifenilo, un procedimiento para su preparacion, su empleo en la preparacion de medicamentos, las composiciones farmaceuticas que los contieneny un procedimiento para preparar estas composiciones farmaceuticas |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1098892A1 (es) |
| JP (1) | JP2002521377A (es) |
| KR (1) | KR20010070997A (es) |
| CN (1) | CN1309654A (es) |
| AR (1) | AR019415A1 (es) |
| AU (1) | AU5033899A (es) |
| BR (1) | BR9912299A (es) |
| CA (1) | CA2338209A1 (es) |
| HU (1) | HUP0102622A3 (es) |
| ID (1) | ID27846A (es) |
| NO (1) | NO20010333D0 (es) |
| PL (1) | PL345283A1 (es) |
| SK (1) | SK492001A3 (es) |
| WO (1) | WO2000005225A1 (es) |
| ZA (1) | ZA200101379B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0302751A3 (en) * | 2000-11-14 | 2007-06-28 | Merck Patent Gmbh | Novel uses of combined 5-ht1a agonists and serotonin reuptake inhibitors |
| EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| US7718650B2 (en) | 2001-05-11 | 2010-05-18 | Biovitrum Ab | Aryl sulfonamide compounds for treating obesity |
| PL366619A1 (en) * | 2001-05-11 | 2005-02-07 | Biovitrum Ab | Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders |
| WO2003024448A2 (en) | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
| JP2008508221A (ja) | 2004-07-28 | 2008-03-21 | グラクソ グループ リミテッド | 消化器疾患の治療に有用なピペラジン誘導体 |
| EP2311802A1 (en) * | 2004-10-14 | 2011-04-20 | Abbott GmbH & Co. KG | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| WO2007077457A2 (en) * | 2006-01-06 | 2007-07-12 | The Royal Veterinary College | Treatment of equine laminitis with 5-ht1b/ 1d antagonists |
| JP2009531385A (ja) | 2006-03-31 | 2009-09-03 | グラクソ グループ リミテッド | 成長ホルモン分泌促進物質（ｇｈｓ）受容体アゴニストとしてのピペラジン誘導体 |
| MX2008013434A (es) * | 2006-04-19 | 2009-01-26 | Abbott Gmbh & Co Kg | Arilsufonas heterociclicas adecuadas para tratar trastornos que responden a la modulacion del receptor de serotonina 5ht6. |
| CN101421264A (zh) | 2006-04-19 | 2009-04-29 | 艾博特股份有限两合公司 | 适用于治疗对血清素5ht6受体调节有反应的病症的杂环化合物 |
| MX2008014743A (es) | 2006-05-19 | 2008-12-01 | Wyeth Corp | N-benzoil- y n-bencilpirrolidin-3-ilaminas como antagonistas de histamina-3. |
| BRPI0809142A2 (pt) | 2007-03-23 | 2014-08-26 | Abbott Gmbh & Co Kg | Compostos de azetidina adequados para tratar desordens que respondem à modulação do receptor 5-ht6 de serotonina |
| UA98783C2 (en) | 2007-06-05 | 2012-06-25 | Нсаб, Филиал Аф Ньюросерч Свиден Аб, Свериге | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
| US8835437B2 (en) | 2007-06-08 | 2014-09-16 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| PE20090362A1 (es) | 2007-06-08 | 2009-04-04 | Janssen Pharmaceutica Nv | Derivados de piperidina/piperazina como moduladores de dgat |
| AU2008258560C1 (en) | 2007-06-08 | 2014-04-10 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| ES2617619T3 (es) | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| ES2162792T3 (es) * | 1991-09-18 | 2002-01-16 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d. |
| GB2273930A (en) * | 1992-12-30 | 1994-07-06 | Glaxo Group Ltd | Benzanilide derivatives |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
-
1999
- 1999-07-08 ID IDW20010307A patent/ID27846A/id unknown
- 1999-07-08 WO PCT/EP1999/004803 patent/WO2000005225A1/en not_active Application Discontinuation
- 1999-07-08 SK SK49-2001A patent/SK492001A3/sk unknown
- 1999-07-08 EP EP99934632A patent/EP1098892A1/en not_active Withdrawn
- 1999-07-08 KR KR1020017000849A patent/KR20010070997A/ko not_active Application Discontinuation
- 1999-07-08 CN CN99808739A patent/CN1309654A/zh active Pending
- 1999-07-08 JP JP2000561181A patent/JP2002521377A/ja active Pending
- 1999-07-08 CA CA002338209A patent/CA2338209A1/en not_active Abandoned
- 1999-07-08 AU AU50338/99A patent/AU5033899A/en not_active Abandoned
- 1999-07-08 BR BR9912299-5A patent/BR9912299A/pt not_active Application Discontinuation
- 1999-07-08 PL PL99345283A patent/PL345283A1/xx unknown
- 1999-07-08 HU HU0102622A patent/HUP0102622A3/hu unknown
- 1999-07-16 AR ARP990103510A patent/AR019415A1/es not_active Application Discontinuation
-
2001
- 2001-01-19 NO NO20010333A patent/NO20010333D0/no unknown
- 2001-02-19 ZA ZA200101379A patent/ZA200101379B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID27846A (id) | 2001-04-26 |
| CA2338209A1 (en) | 2000-02-03 |
| WO2000005225A1 (en) | 2000-02-03 |
| BR9912299A (pt) | 2001-11-20 |
| CN1309654A (zh) | 2001-08-22 |
| HUP0102622A3 (en) | 2002-12-28 |
| KR20010070997A (ko) | 2001-07-28 |
| ZA200101379B (en) | 2002-05-20 |
| NO20010333L (no) | 2001-01-19 |
| PL345283A1 (en) | 2001-12-03 |
| EP1098892A1 (en) | 2001-05-16 |
| SK492001A3 (en) | 2001-08-06 |
| NO20010333D0 (no) | 2001-01-19 |
| AU5033899A (en) | 2000-02-14 |
| JP2002521377A (ja) | 2002-07-16 |
| HUP0102622A2 (hu) | 2001-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |