AR006720A1 - Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende - Google Patents
Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprendeInfo
- Publication number
- AR006720A1 AR006720A1 ARP970101598A ARP970101598A AR006720A1 AR 006720 A1 AR006720 A1 AR 006720A1 AR P970101598 A ARP970101598 A AR P970101598A AR P970101598 A ARP970101598 A AR P970101598A AR 006720 A1 AR006720 A1 AR 006720A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- preparing
- azahexane
- substituted
- hetero
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
- C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Abstract
Se refiere a compuestos derivados de azahexano de fórmula (I), en donde: R1 es alcoxicarbonilo inferior; R2 es alquilo inferior secundario o terciarioo alquiltio inferior-alquilo inferior; R3 es fenilo que es no substituido o substituido poru no o más radicales alcoxi inferior, o C4-C8-ciclo-alquilo,R4 es fenilo o ciclohexilo cada uno substituido en la posición 4 por heterociclilo no saturado que está unido por medio de un átomo de carbonodel anillo, tiene de 5 a 8 átomosdel a nillo, contiene de 1 a 4 heteroátomos seleccionados entre nitrógeno, oxígeno, azufre, sulfinilo (-SO-) y sulfonilo(-SO2-) y es no substituido o substituido por alquilo inferior o por feniloalquilo inferior; R5, independientementede R2, y R6, independientementede R1 es alcoxicarbonilo inferior, o sales de los mismos, siempre que por lo menos un grupo formador de sales esté presente, y a un procedimiento paraprepararlos. Los compuestos son inhibidores de la aspartatoproteasa retrovírica y pueden ser usados, por ejemplo, en el tratamiento del SIDA.Presentan excelentes propiedades farmacodinámicas. Se refiere además a una composición farmacéutica que los comprende y a un procedimiento paraprepararla.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH101896 | 1996-04-22 | ||
| CH2997 | 1997-01-08 | ||
| CH22397 | 1997-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006720A1 true AR006720A1 (es) | 1999-09-08 |
Family
ID=27171723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101598A AR006720A1 (es) | 1996-04-22 | 1997-04-21 | Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0900210B1 (es) |
| JP (1) | JP3174347B2 (es) |
| CN (3) | CN1310905C (es) |
| AR (1) | AR006720A1 (es) |
| AT (1) | ATE288903T1 (es) |
| AU (1) | AU706183B2 (es) |
| BR (1) | BR9701877A (es) |
| CA (3) | CA2568104C (es) |
| CY (1) | CY2596B2 (es) |
| CZ (1) | CZ296135B6 (es) |
| DE (2) | DE69732483T2 (es) |
| DK (1) | DK0900210T3 (es) |
| EA (1) | EA001794B1 (es) |
| ES (1) | ES2238720T3 (es) |
| FR (1) | FR05C0030I2 (es) |
| HK (2) | HK1018788A1 (es) |
| HU (1) | HU224125B1 (es) |
| IL (1) | IL126381A (es) |
| LU (1) | LU91189I2 (es) |
| MY (1) | MY114457A (es) |
| NL (1) | NL300203I2 (es) |
| NO (2) | NO313330B1 (es) |
| NZ (3) | NZ509045A (es) |
| PT (1) | PT900210E (es) |
| SI (1) | SI0900210T1 (es) |
| SK (1) | SK285048B6 (es) |
| TW (1) | TW409125B (es) |
| WO (1) | WO1997040029A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087383A (en) * | 1998-01-20 | 2000-07-11 | Bristol-Myers Squibb Company | Bisulfate salt of HIV protease inhibitor |
| US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| EP1077977A1 (en) * | 1998-05-15 | 2001-02-28 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| EP0976736A1 (en) * | 1998-07-29 | 2000-02-02 | SUMIKA FINE CHEMICALS Co., Ltd. | Production method of 2-(p-alkylphenyl)pyridine compound |
| ATE239707T1 (de) | 1998-08-07 | 2003-05-15 | Sumika Fine Chemicals Co Ltd | 2-phenylpyridine-derivate und verfahren zu deren herstellung |
| US6197803B1 (en) | 1998-12-09 | 2001-03-06 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
| US6255349B1 (en) | 1998-12-09 | 2001-07-03 | American Home Products Corporation | Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group |
| US6207715B1 (en) | 1998-12-09 | 2001-03-27 | American Home Products Corporation | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group |
| US6335350B1 (en) | 1998-12-09 | 2002-01-01 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
| JP4222671B2 (ja) | 1999-02-15 | 2009-02-12 | 住友化学株式会社 | ヒドラジン誘導体の製造方法 |
| IT1313664B1 (it) * | 1999-10-12 | 2002-09-09 | Norpharma S P A | Processo per la preparazione di un composto aril-piridinico. |
| JP4278316B2 (ja) * | 2000-07-14 | 2009-06-10 | 住友化学株式会社 | ヒドラジン誘導体の製造方法 |
| US6365745B1 (en) | 2000-07-14 | 2002-04-02 | Sumika Fine Chemicals Co., Ltd. | Method for producing hydrazine derivative |
| EP1546106A1 (en) | 2002-10-02 | 2005-06-29 | Euticals Prime European Therapeutical S.P.A | Process for the preparation of aryl-pyridyl compounds |
| CA2510006C (en) * | 2002-12-06 | 2012-02-07 | Vertex Pharmaceuticals Incorporated | Compositions comprising a combination of diphenyl urea impdh inhibitors and apoptosis-inducing anti-cancer agents |
| ITMI20032338A1 (it) * | 2003-11-28 | 2005-05-29 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Composti feniltetrazolici. |
| CN1980666B (zh) * | 2004-05-04 | 2011-03-30 | 布里斯托尔-迈尔斯斯奎布公司 | 制备阿扎那韦硫酸氢盐的方法和新的形式 |
| BRPI0607230A2 (pt) | 2005-02-10 | 2009-08-25 | Medivir Ab | inibidores de protease hiv |
| EP2069303B1 (en) * | 2006-07-21 | 2016-03-30 | Gilead Sciences, Inc. | Antiviral protease inhibitors |
| CN101711237B (zh) * | 2007-06-12 | 2013-08-07 | 康塞特制药公司 | 氮杂肽衍生物 |
| WO2009130534A1 (en) * | 2008-04-24 | 2009-10-29 | Oxyrane (Pty) Ltd. | Process for synthesizing atazanavir |
| EP2272830A1 (en) * | 2009-06-18 | 2011-01-12 | Esteve Química, S.A. | Preparation process of an antivirally heterocyclic azahexane derivative |
| EP2272831A1 (en) | 2009-06-26 | 2011-01-12 | Prime European Therapeuticals S.p.A. | Process for the preparation of arylpyridinyl compounds |
| WO2011037467A1 (en) | 2009-09-28 | 2011-03-31 | Stichting Katholieke Universiteit | Atazanavir for treating inflammatory diseases |
| WO2011080562A1 (en) | 2009-12-29 | 2011-07-07 | Hetero Research Foundation | Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals |
| WO2011107843A2 (en) * | 2010-03-01 | 2011-09-09 | Lupin Limited | Process for the preparation of atazanavir sulfate substantially free of diastereomers |
| US20130224294A1 (en) | 2010-09-28 | 2013-08-29 | Ratiopharm Gmbh | Dry processing of atazanavir |
| US20140343290A1 (en) * | 2011-07-27 | 2014-11-20 | Rakesh Kumar Singh | Process for the preparation of atazanavir or its bisulfate salt |
| AU2013340559B2 (en) | 2012-10-29 | 2018-03-15 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
| CN104250224A (zh) * | 2013-06-28 | 2014-12-31 | 上海威智医药科技有限公司 | 阿扎那韦富马酸盐及其制备和应用 |
| CN104163787A (zh) * | 2014-08-08 | 2014-11-26 | 山东威智医药工业有限公司 | 阿扎那韦及其硫酸盐的制备方法 |
| CN107459496B (zh) * | 2016-06-03 | 2022-07-19 | 华东理工大学 | 噻唑类衍生物在治疗病毒感染中的应用 |
| JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
| CN107245052A (zh) * | 2017-06-21 | 2017-10-13 | 连云港杰瑞药业有限公司 | 一种阿扎那韦制备方法 |
| TWI766172B (zh) | 2018-07-30 | 2022-06-01 | 美商基利科學股份有限公司 | 抗hiv化合物 |
| CN109251165B (zh) * | 2018-10-02 | 2022-09-23 | 国药集团川抗制药有限公司 | 阿扎那韦达二4-氨基苯磺酸盐及其制备方法 |
| CN109574916A (zh) * | 2018-12-29 | 2019-04-05 | 常州吉恩药业有限公司 | 阿扎那韦中间体2-[4-(2-吡啶基)苄基]-肼羧酸叔丁酯的工业化生产方法 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN113603634B (zh) * | 2021-08-06 | 2023-03-21 | 江苏八巨药业有限公司 | 一种阿扎那韦中间体的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913840A1 (en) * | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
| EP0521827B1 (de) * | 1991-07-03 | 1996-09-25 | Ciba-Geigy Ag | Pharmakologisch wirksame Hydrazinderivate und Verfahren zu deren Herstellung |
| ES2093394T3 (es) * | 1992-12-23 | 1996-12-16 | Ciba Geigy Ag | Derivados de hidrazina antiretrovirales. |
| DE10199053I1 (de) * | 1992-12-29 | 2002-08-29 | Abbott Lab | Inhibitoren der retroviralen Protease |
| US5461067A (en) * | 1993-02-25 | 1995-10-24 | Abbott Laboratories | Retroviral protease inhibiting compounds |
-
1997
- 1997-04-02 TW TW086104224A patent/TW409125B/zh not_active IP Right Cessation
- 1997-04-08 MY MYPI97001496A patent/MY114457A/en unknown
- 1997-04-14 SI SI9730702T patent/SI0900210T1/xx unknown
- 1997-04-14 PT PT97919355T patent/PT900210E/pt unknown
- 1997-04-14 HU HU9901612A patent/HU224125B1/hu active IP Right Grant
- 1997-04-14 WO PCT/EP1997/001860 patent/WO1997040029A1/en active IP Right Grant
- 1997-04-14 CA CA002568104A patent/CA2568104C/en not_active Expired - Lifetime
- 1997-04-14 CN CNB2004100791875A patent/CN1310905C/zh not_active Expired - Lifetime
- 1997-04-14 NZ NZ509045A patent/NZ509045A/xx not_active IP Right Cessation
- 1997-04-14 CN CN97194025A patent/CN1082508C/zh not_active Expired - Lifetime
- 1997-04-14 AT AT97919355T patent/ATE288903T1/de active
- 1997-04-14 DK DK97919355T patent/DK0900210T3/da active
- 1997-04-14 EP EP97919355A patent/EP0900210B1/en not_active Expired - Lifetime
- 1997-04-14 NZ NZ332118A patent/NZ332118A/en not_active IP Right Cessation
- 1997-04-14 DE DE69732483T patent/DE69732483T2/de not_active Expired - Lifetime
- 1997-04-14 CZ CZ0337398A patent/CZ296135B6/cs not_active IP Right Cessation
- 1997-04-14 CA CA002510945A patent/CA2510945C/en not_active Expired - Lifetime
- 1997-04-14 EA EA199800899A patent/EA001794B1/ru not_active IP Right Cessation
- 1997-04-14 SK SK1452-98A patent/SK285048B6/sk not_active IP Right Cessation
- 1997-04-14 JP JP53768697A patent/JP3174347B2/ja not_active Expired - Lifetime
- 1997-04-14 ES ES97919355T patent/ES2238720T3/es not_active Expired - Lifetime
- 1997-04-14 IL IL12638197A patent/IL126381A/xx not_active IP Right Cessation
- 1997-04-14 AU AU23859/97A patent/AU706183B2/en not_active Expired
- 1997-04-14 CA CA002250840A patent/CA2250840C/en not_active Expired - Lifetime
- 1997-04-14 DE DE200512000003 patent/DE122005000003I1/de active Pending
- 1997-04-21 AR ARP970101598A patent/AR006720A1/es active IP Right Grant
- 1997-04-22 BR BR9701877A patent/BR9701877A/pt not_active IP Right Cessation
-
1998
- 1998-04-14 NO NO19984900A patent/NO313330B1/no not_active IP Right Cessation
-
1999
- 1999-09-09 HK HK99103921A patent/HK1018788A1/xx not_active IP Right Cessation
-
2000
- 2000-12-20 NZ NZ509046A patent/NZ509046A/en not_active IP Right Cessation
-
2001
- 2001-02-16 CN CNB011034947A patent/CN1193010C/zh not_active Expired - Lifetime
-
2005
- 2005-04-13 NO NO2005010C patent/NO2005010I1/no unknown
- 2005-07-05 FR FR05C0030C patent/FR05C0030I2/fr active Active
- 2005-07-28 NL NL300203C patent/NL300203I2/nl unknown
- 2005-08-03 LU LU91189C patent/LU91189I2/fr unknown
- 2005-08-22 HK HK05107291A patent/HK1075043A1/xx not_active IP Right Cessation
-
2006
- 2006-07-28 CY CY0600019A patent/CY2596B2/xx unknown
Also Published As
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