AP835A - Metered dose inhaler for beclomethasone dipropionate. - Google Patents

Metered dose inhaler for beclomethasone dipropionate. Download PDF

Info

Publication number: AP835A
Authority: AP; ARIPO
Prior art keywords: inhaler according; fluorocarbon; propellant; polymer; drug formulation
Prior art date: 1995-04-14

Application number

APAP/P/1997/001112A

Other languages

English (en)

Other versions

AP9701112A0 (en

Inventor

Ian C Ashurst

Craig S Herman

Michael T Riebe

Li Li-Bovet

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-14

Filing date

1996-04-11

Publication date

2000-05-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23674168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP835(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-04-11 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

1997-10-31 Publication of AP9701112A0 publication Critical patent/AP9701112A0/xx

2000-05-12 Application granted granted Critical

2000-05-12 Publication of AP835A publication Critical patent/AP835A/en

Links

KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title claims abstract description 23
229950000210 beclometasone dipropionate Drugs 0.000 title claims abstract description 20
229940071648 metered dose inhaler Drugs 0.000 title claims abstract description 11
229920002313 fluoropolymer Polymers 0.000 claims abstract description 36
239000003380 propellant Substances 0.000 claims abstract description 34
239000013583 drug formulation Substances 0.000 claims abstract description 30
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract description 18
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 15
229920000642 polymer Polymers 0.000 claims abstract description 11
239000012453 solvate Substances 0.000 claims abstract description 11
239000013543 active substance Substances 0.000 claims abstract description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
239000000203 mixture Substances 0.000 claims description 36
238000009472 formulation Methods 0.000 claims description 24
239000004812 Fluorinated ethylene propylene Substances 0.000 claims description 16
229940038482 beclomethasone dipropionate monohydrate Drugs 0.000 claims description 15
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
229910052782 aluminium Inorganic materials 0.000 claims description 12
239000004094 surface-active agent Substances 0.000 claims description 12
239000004813 Perfluoroalkoxy alkane Substances 0.000 claims description 11
239000006184 cosolvent Substances 0.000 claims description 10
229920002959 polymer blend Polymers 0.000 claims description 10
229920001343 polytetrafluoroethylene Polymers 0.000 claims description 9
239000004810 polytetrafluoroethylene Substances 0.000 claims description 9
229920006393 polyether sulfone Polymers 0.000 claims description 8
239000004962 Polyamide-imide Substances 0.000 claims description 7
239000004695 Polyether sulfone Substances 0.000 claims description 7
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229910052751 metal Inorganic materials 0.000 claims description 7
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LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 6
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GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 3
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TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical group FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims 1
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LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 2
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XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
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BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
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125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
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150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
238000002664 inhalation therapy Methods 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 1
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230000007246 mechanism Effects 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 description 1
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PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
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NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 description 1
229960000797 oxitropium Drugs 0.000 description 1
RLANKEDHRWMNRO-UHFFFAOYSA-M oxtriphylline Chemical compound C[N+](C)(C)CCO.O=C1N(C)C(=O)N(C)C2=C1[N-]C=N2 RLANKEDHRWMNRO-UHFFFAOYSA-M 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
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DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
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BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0222—Materials for reducing friction

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Mechanical Engineering (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Otolaryngology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

APAP/P/1997/001112A 1995-04-14 1996-04-11 Metered dose inhaler for beclomethasone dipropionate. AP835A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42228095A	1995-04-14	1995-04-14
PCT/US1996/005009 WO1996032345A1 (en)	1995-04-14	1996-04-11	Metered dose inhaler for beclomethasone dipropionate

Publications (2)

Publication Number	Publication Date
AP9701112A0 AP9701112A0 (en)	1997-10-31
AP835A true AP835A (en)	2000-05-12

Family

ID=23674168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1997/001112A AP835A (en)	1995-04-14	1996-04-11	Metered dose inhaler for beclomethasone dipropionate.

Country Status (26)

Country	Link
US (3)	US6149892A (no)
EP (1)	EP0820414B1 (no)
JP (1)	JP3573213B2 (no)
KR (1)	KR19980703850A (no)
CN (1)	CN1186473A (no)
AP (1)	AP835A (no)
AT (1)	ATE258813T1 (no)
AU (1)	AU718851B2 (no)
BG (1)	BG102023A (no)
BR (1)	BR9604979A (no)
CA (1)	CA2218179A1 (no)
CZ (1)	CZ326197A3 (no)
DE (1)	DE69631476T2 (no)
EA (1)	EA000889B1 (no)
EE (1)	EE9700372A (no)
ES (1)	ES2214536T3 (no)
GE (1)	GEP20002266B (no)
HU (1)	HUP9800641A3 (no)
IS (1)	IS4581A (no)
NO (1)	NO974738L (no)
NZ (1)	NZ306281A (no)
OA (1)	OA10625A (no)
PL (1)	PL180880B1 (no)
SK (1)	SK139197A3 (no)
TR (1)	TR199701170T1 (no)
WO (1)	WO1996032345A1 (no)

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KR19980703850A (ko) *	1995-04-14	1998-12-05	그레이엄브레레톤	베클로메타손 디프로피오네이트용 계량 흡입기
HU219899B (hu) *	1995-04-14	2001-09-28	Glaxo Wellcome Inc.	Inhalálóberendezés flutikaszon-propionát adagolására mért dózisban
GB9526392D0 (en)	1995-12-22	1996-02-21	Glaxo Group Ltd	Medicaments
GB9616237D0 (en)	1996-08-01	1996-09-11	Norton Healthcare Ltd	Aerosol formulations
US6413496B1 (en)	1996-12-04	2002-07-02	Biogland Ireland (R&D) Limited	Pharmaceutical compositions and devices for their administration
DK1011646T3 (da) *	1996-12-04	2005-09-19	Link Products Ltd	Farmaceutiske præparater og indretninger til administration heraf
CN1269722A (zh) *	1997-03-18	2000-10-11	Basf公司	调节对皮质类固醇反应的方法及组合物
US6054487A (en) *	1997-03-18	2000-04-25	Basf Aktiengesellschaft	Methods and compositions for modulating responsiveness to corticosteroids
US6120752A (en) *	1997-05-21	2000-09-19	3M Innovative Properties Company	Medicinal aerosol products containing formulations of ciclesonide and related steroids
US20010031244A1 (en) *	1997-06-13	2001-10-18	Chiesi Farmaceutici S.P.A.	Pharmaceutical aerosol composition
GB2328932B (en) *	1997-09-03	1999-10-13	Bespak Plc	Improvements in or relating to metering valves for pressurised dispensing containers
US20030103906A1 (en) *	1997-10-14	2003-06-05	Smithkline Beecham Corporation	Metered dose inhaler having internal surfaces coated with fluorocarbon polymer
GB9814717D0 (en) *	1998-02-23	1998-09-02	Bespak Plc	Improvements in drug delivery devices
IL137650A0 (en) *	1998-02-23	2001-10-31	Glaxo Group Ltd	Drug delivery devices
AU753921B2 (en) *	1998-02-23	2002-10-31	Glaxo Group Limited	Improvements in drug delivery devices
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JP2002512871A (ja) *	1998-04-30	2002-05-08	スリーエムイノベイティブプロパティズカンパニー	製薬エアロゾル用定量弁
GB2340759B (en) *	1998-08-26	2003-05-07	Bespak Plc	Improvements in drug delivery devices
DZ2947A1 (fr) *	1998-11-25	2004-03-15	Chiesi Farma Spa	Inhalateur à compteur de dose sous pression.
US6390291B1 (en)	1998-12-18	2002-05-21	Smithkline Beecham Corporation	Method and package for storing a pressurized container containing a drug
US6352152B1 (en)	1998-12-18	2002-03-05	Smithkline Beecham Corporation	Method and package for storing a pressurized container containing a drug
US6315112B1 (en)	1998-12-18	2001-11-13	Smithkline Beecham Corporation	Method and package for storing a pressurized container containing a drug
DE60023674T2 (de)	1999-03-12	2006-06-08	Glaxo Group Ltd., Greenford	Dossierventil
US6315985B1 (en) *	1999-06-18	2001-11-13	3M Innovative Properties Company	C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1313553B1 (it)	1999-07-23	2002-09-09	Chiesi Farma Spa	Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317720B1 (it) *	2000-01-07	2003-07-15	Chiesi Farma Spa	Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
DE10004465A1 (de) *	2000-02-02	2001-08-16	Pari Gmbh	Inhalationsvernebler
IT1317846B1 (it) *	2000-02-22	2003-07-15	Chiesi Farma Spa	Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
CN100341483C (zh)	2000-02-28	2007-10-10	维克丘拉有限公司	口服药物输递中或涉及口服药物输递的改进
WO2001064524A2 (en) *	2000-03-01	2001-09-07	Glaxo Group Limited	Metered dose inhaler
JP2003525091A (ja) *	2000-03-01	2003-08-26	グラクソグループリミテッド	定量噴霧式吸入器
JP2003525089A (ja) *	2000-03-01	2003-08-26	グラクソグループリミテッド	定量噴霧式吸入器
WO2001064274A2 (en) *	2000-03-01	2001-09-07	Glaxo Group Limited	Metered dose inhaler
IT1318514B1 (it) *	2000-05-12	2003-08-27	Chiesi Farma Spa	Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
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- 1996-04-11 BR BR9604979A patent/BR9604979A/pt not_active Application Discontinuation
- 1996-04-11 HU HU9800641A patent/HUP9800641A3/hu unknown
- 1996-04-11 EE EE9700372A patent/EE9700372A/xx unknown
- 1996-04-11 DE DE1996631476 patent/DE69631476T2/de not_active Revoked
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1997
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- 2000-02-18 US US09/506,838 patent/US6511653B1/en not_active Expired - Fee Related
- 2000-02-18 US US09/506,834 patent/US6511652B1/en not_active Expired - Fee Related

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Also Published As

Publication number	Publication date
MX9707878A (es)	1997-11-29
EE9700372A (et)	1998-06-15
KR19980703850A (ko)	1998-12-05
HUP9800641A2 (hu)	1998-08-28
JP3573213B2 (ja)	2004-10-06
CN1186473A (zh)	1998-07-01
DE69631476T2 (de)	2005-01-13
GEP20002266B (en)	2000-10-25
TR199701170T1 (xx)	1998-02-21
NZ306281A (en)	1999-07-29
NO974738L (no)	1997-12-11
BG102023A (bg)	1998-07-31
EA000889B1 (ru)	2000-06-26
NO974738D0 (no)	1997-10-13
IS4581A (is)	1997-10-07
PL180880B1 (pl)	2001-04-30
PL322781A1 (en)	1998-02-16
CA2218179A1 (en)	1996-10-17
BR9604979A (pt)	1998-06-09
EA199700230A1 (ru)	1998-02-26
US6149892A (en)	2000-11-21
JP2000513237A (ja)	2000-10-10
EP0820414B1 (en)	2004-02-04
EP0820414A1 (en)	1998-01-28
HUP9800641A3 (en)	2001-04-28
DE69631476D1 (de)	2004-03-11
SK139197A3 (en)	1998-04-08
ES2214536T3 (es)	2004-09-16
US6511653B1 (en)	2003-01-28
AP9701112A0 (en)	1997-10-31
CZ326197A3 (cs)	1999-06-16
WO1996032345A1 (en)	1996-10-17
AU718851B2 (en)	2000-04-20
ATE258813T1 (de)	2004-02-15
OA10625A (en)	2001-04-24
AU5481296A (en)	1996-10-30
US6511652B1 (en)	2003-01-28

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US20030103906A1 (en)	2003-06-05	Metered dose inhaler having internal surfaces coated with fluorocarbon polymer
AU751859B2 (en)	2002-08-29	Metered dose inhaler for beclomethasone dipropionate
AU4517000A (en)	2000-09-21	Metered dose inhaler for salmeterol