NO311838B1 - 3-Azetidinylalkylpiperidiner eller -pyrrolidiner som takykininantagonister - Google Patents

3-Azetidinylalkylpiperidiner eller -pyrrolidiner som takykininantagonister Download PDF

Info

Publication number: NO311838B1
Authority: NO; Norway
Prior art keywords: compound; formula; dichlorophenyl; solution; direct bond
Prior art date: 1996-01-05

Application number

NO19982651A

Other languages

English (en)

Norwegian (no)

Other versions

NO982651L (no

NO982651D0 (no

Inventor

Alexander Roderick Mackenzie

Allan Patrick Marchington

Donald Stuart Middleton

Sandra Dora Meadows

Original Assignee

Pfizer Res And Dev Co Nv Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-05

Filing date

1998-06-09

Publication date

2002-02-04

1998-06-09 Application filed by Pfizer Res And Dev Co Nv Sa filed Critical Pfizer Res And Dev Co Nv Sa

1998-06-09 Publication of NO982651L publication Critical patent/NO982651L/no

1998-06-09 Publication of NO982651D0 publication Critical patent/NO982651D0/no

2002-02-04 Publication of NO311838B1 publication Critical patent/NO311838B1/no

Links

102000003141 Tachykinin Human genes 0.000 title claims abstract description 7
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239000005557 antagonist Substances 0.000 title abstract description 5
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150000001875 compounds Chemical class 0.000 claims abstract description 220
150000003839 salts Chemical class 0.000 claims abstract description 45
-1 4-aminosulfonylpiperazin-1-yl Chemical group 0.000 claims description 96
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 78
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238000000034 method Methods 0.000 claims description 42
238000006243 chemical reaction Methods 0.000 claims description 38
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
239000002253 acid Substances 0.000 claims description 31
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 28
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
208000035475 disorder Diseases 0.000 claims description 22
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235000011152 sodium sulphate Nutrition 0.000 description 1
PCVKFNSNKBXJFZ-UHFFFAOYSA-M sodium;3-bromopropanoate Chemical compound [Na+].[O-]C(=O)CCBr PCVKFNSNKBXJFZ-UHFFFAOYSA-M 0.000 description 1
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GHCSIFASLFMJDZ-UHFFFAOYSA-N tert-butyl 3-(4-sulfamoylpiperazin-1-yl)azetidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC1N1CCN(S(N)(=O)=O)CC1 GHCSIFASLFMJDZ-UHFFFAOYSA-N 0.000 description 1
KEQBTRKQDYXHTO-UHFFFAOYSA-N tert-butyl 3-piperazin-1-ylazetidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC1N1CCNCC1 KEQBTRKQDYXHTO-UHFFFAOYSA-N 0.000 description 1
NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 1
FODWRUPJCKASBN-UHFFFAOYSA-M tetrabutylazanium;chloride;hydrate Chemical compound O.[Cl-].CCCC[N+](CCCC)(CCCC)CCCC FODWRUPJCKASBN-UHFFFAOYSA-M 0.000 description 1
150000003527 tetrahydropyrans Chemical group 0.000 description 1
OSBSFAARYOCBHB-UHFFFAOYSA-N tetrapropylammonium Chemical compound CCC[N+](CCC)(CCC)CCC OSBSFAARYOCBHB-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
125000005505 thiomorpholino group Chemical group 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
238000001665 trituration Methods 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19982651A 1996-01-05 1998-06-09 3-Azetidinylalkylpiperidiner eller -pyrrolidiner som takykininantagonister NO311838B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9600235.7A GB9600235D0 (en)	1996-01-05	1996-01-05	Therapeutic agents
PCT/EP1996/005613 WO1997025322A1 (en)	1996-01-05	1996-12-09	3-azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists

Publications (3)

Publication Number	Publication Date
NO982651L NO982651L (no)	1998-06-09
NO982651D0 NO982651D0 (no)	1998-06-09
NO311838B1 true NO311838B1 (no)	2002-02-04

Family

ID=10786682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19982651A NO311838B1 (no)	1996-01-05	1998-06-09	3-Azetidinylalkylpiperidiner eller -pyrrolidiner som takykininantagonister

Country Status (38)

Country	Link
US (1)	US6242438B1 (ko)
EP (1)	EP0871623B1 (ko)
JP (2)	JP3123611B2 (ko)
KR (1)	KR100275402B1 (ko)
AP (1)	AP709A (ko)
AR (2)	AR005339A1 (ko)
AT (1)	ATE232526T1 (ko)
AU (1)	AU708282B2 (ko)
BG (1)	BG102589A (ko)
BR (1)	BR9612412A (ko)
CA (1)	CA2237189C (ko)
CO (1)	CO4750815A1 (ko)
CZ (1)	CZ209398A3 (ko)
DE (1)	DE69626220T2 (ko)
DK (1)	DK0871623T3 (ko)
DZ (1)	DZ2155A1 (ko)
ES (1)	ES2190486T3 (ko)
GB (1)	GB9600235D0 (ko)
HR (1)	HRP970006A2 (ko)
HU (1)	HUP9903590A3 (ko)
IL (2)	IL124309A (ko)
IS (1)	IS1876B (ko)
MA (1)	MA26417A1 (ko)
NO (1)	NO311838B1 (ko)
NZ (1)	NZ324712A (ko)
OA (1)	OA10863A (ko)
PE (1)	PE29798A1 (ko)
PL (1)	PL185723B1 (ko)
RU (1)	RU2158264C2 (ko)
SI (1)	SI0871623T1 (ko)
SK (1)	SK89598A3 (ko)
TN (1)	TNSN96174A1 (ko)
TR (1)	TR199801268T2 (ko)
TW (1)	TW472054B (ko)
UY (1)	UY24429A1 (ko)
WO (1)	WO1997025322A1 (ko)
YU (1)	YU71496A (ko)
ZA (1)	ZA9747B (ko)

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GB9714129D0 (en)	1997-07-04	1997-09-10	Pfizer Ltd	Azetidines
AU1089599A (en) *	1997-10-15	1999-05-03	Coelacanth Chemical Corporation	Synthesis of azetidine derivatives
CA2312770A1 (en) *	1997-12-04	1999-06-10	Takahide Nishi	Alicyclic acylated heterocyclic derivatives
GB9821898D0 (en) *	1998-10-08	1998-12-02	Pfizer Ltd	Heterocycles
EP1299100B1 (en) *	2000-06-12	2007-07-25	The University Of Rochester	Method of treating hot flashes, using tachykinin receptor antagonist
US6642226B2 (en) *	2001-02-06	2003-11-04	Hoffman-La Roche Inc.	Substituted phenyl-piperidine methanone compounds
GB0130261D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Lactams as tachykinin antagonists
US7674783B2 (en) *	2002-11-22	2010-03-09	Dimera Inc.	Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease
AU2003299249B2 (en) *	2002-12-23	2010-05-27	Janssen Pharmaceutica N.V.	Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
TW200508221A (en)	2003-06-13	2005-03-01	Astrazeneca Ab	New azetidine compounds
CA2589565A1 (en) *	2004-06-24	2006-01-05	Incyte Corporation	Amido compounds and their use as pharmaceuticals
CA2570637A1 (en)	2004-06-24	2006-02-02	Wenqing Yao	N-substituted piperidines and their use as pharmaceuticals
MX2007011079A (es)	2005-03-08	2007-10-08	Janssen Pharmaceutica Nv	Derivados de diaza-espiro-[4-4]-nonano como antagonistas de la neurocinina (nk1).
AR057828A1 (es)	2005-09-29	2007-12-19	Astrazeneca Ab	Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
US8106208B2 (en)	2006-05-18	2012-01-31	Albireo Ab	Benzamide compounds that act as NK receptor antagonists
CN101641099A (zh)	2007-01-24	2010-02-03	葛兰素集团有限公司	包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物
WO2010071575A1 (en) *	2008-12-16	2010-06-24	Astrazeneca Ab	Quaternary piperidine derivatives and uses thereof
SI2421825T1 (sl) *	2009-04-22	2014-04-30	Janssen Pharmaceutica N.V.	Azetidinil diamidi kot inhibitorji monoacilglicerol lipaze

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
AU678023B2 (en) *	1993-05-06	1997-05-15	Aventis Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
FR2719311B1 (fr) *	1994-03-18	1998-06-26	Sanofi Sa	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
TW432061B (en) *	1994-08-09	2001-05-01	Pfizer Res & Dev	Lactams
GB9601202D0 (en) *	1996-01-22	1996-03-20	Pfizer Ltd	Piperidones
GB9812037D0 (en) *	1998-06-04	1998-07-29	Pfizer Ltd	Piperidones
GB9821898D0 (en) *	1998-10-08	1998-12-02	Pfizer Ltd	Heterocycles

1996
- 1996-01-05 GB GBGB9600235.7A patent/GB9600235D0/en active Pending
- 1996-12-06 TW TW085115107A patent/TW472054B/zh not_active IP Right Cessation
- 1996-12-09 CA CA002237189A patent/CA2237189C/en not_active Expired - Fee Related
- 1996-12-09 PL PL96327665A patent/PL185723B1/pl not_active IP Right Cessation
- 1996-12-09 ES ES96943119T patent/ES2190486T3/es not_active Expired - Lifetime
- 1996-12-09 US US09/297,736 patent/US6242438B1/en not_active Expired - Fee Related
- 1996-12-09 EP EP96943119A patent/EP0871623B1/en not_active Expired - Lifetime
- 1996-12-09 DK DK96943119T patent/DK0871623T3/da active
- 1996-12-09 CZ CZ982093A patent/CZ209398A3/cs unknown
- 1996-12-09 SK SK895-98A patent/SK89598A3/sk unknown
- 1996-12-09 HU HU9903590A patent/HUP9903590A3/hu unknown
- 1996-12-09 RU RU98114667/04A patent/RU2158264C2/ru not_active IP Right Cessation
- 1996-12-09 KR KR1019980705159A patent/KR100275402B1/ko not_active IP Right Cessation
- 1996-12-09 NZ NZ324712A patent/NZ324712A/xx unknown
- 1996-12-09 DE DE69626220T patent/DE69626220T2/de not_active Expired - Fee Related
- 1996-12-09 BR BR9612412A patent/BR9612412A/pt not_active Application Discontinuation
- 1996-12-09 AU AU11950/97A patent/AU708282B2/en not_active Ceased
- 1996-12-09 AT AT96943119T patent/ATE232526T1/de not_active IP Right Cessation
- 1996-12-09 IL IL12430996A patent/IL124309A/en not_active IP Right Cessation
- 1996-12-09 SI SI9630590T patent/SI0871623T1/xx unknown
- 1996-12-09 TR TR1998/01268T patent/TR199801268T2/xx unknown
- 1996-12-09 JP JP09520769A patent/JP3123611B2/ja not_active Expired - Fee Related
- 1996-12-09 IL IL14532496A patent/IL145324A0/xx unknown
- 1996-12-09 WO PCT/EP1996/005613 patent/WO1997025322A1/en not_active Application Discontinuation
- 1996-12-19 AP APAP/P/1996/000901A patent/AP709A/en active
- 1996-12-27 PE PE1996000960A patent/PE29798A1/es not_active Application Discontinuation
- 1996-12-31 YU YU71496A patent/YU71496A/sr unknown
- 1996-12-31 DZ DZ960200A patent/DZ2155A1/fr active
- 1996-12-31 MA MA24446A patent/MA26417A1/fr unknown
- 1996-12-31 TN TNTNSN96174A patent/TNSN96174A1/fr unknown
1997
- 1997-01-02 AR ARP970100004A patent/AR005339A1/es unknown
- 1997-01-02 AR ARP970100003A patent/AR005338A1/es unknown
- 1997-01-03 ZA ZA9747A patent/ZA9747B/xx unknown
- 1997-01-03 UY UY24429A patent/UY24429A1/es not_active Application Discontinuation
- 1997-01-03 HR HR9600235.7A patent/HRP970006A2/xx not_active Application Discontinuation
- 1997-01-07 CO CO97000263A patent/CO4750815A1/es unknown
1998
- 1998-05-28 IS IS4760A patent/IS1876B/is unknown
- 1998-05-29 OA OA9800066A patent/OA10863A/en unknown
- 1998-06-09 NO NO19982651A patent/NO311838B1/no unknown
- 1998-06-30 BG BG102589A patent/BG102589A/xx unknown
2000
- 2000-05-10 JP JP2000136658A patent/JP3254205B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL327665A1 (en)	1998-12-21
SI0871623T1 (en)	2003-08-31
OA10863A (en)	2001-09-27
AP709A (en)	1998-12-22
KR19990077027A (ko)	1999-10-25
DZ2155A1 (fr)	2002-10-26
JPH11501667A (ja)	1999-02-09
IS1876B (is)	2003-05-28
IL145324A0 (en)	2002-06-30
AR005338A1 (es)	1999-04-28
ATE232526T1 (de)	2003-02-15
IL124309A0 (en)	1998-12-06
YU71496A (en)	1999-11-22
AU708282B2 (en)	1999-07-29
GB9600235D0 (en)	1996-03-06
HUP9903590A3 (en)	2002-01-28
TW472054B (en)	2002-01-11
ZA9747B (en)	1998-09-30
WO1997025322A1 (en)	1997-07-17
HUP9903590A2 (hu)	2000-05-28
TR199801268T2 (xx)	1998-10-21
AR005339A1 (es)	1999-04-28
SK89598A3 (en)	2000-02-14
CO4750815A1 (es)	1999-03-31
UY24429A1 (es)	2001-08-27
AP9600901A0 (en)	1997-01-31
HRP970006A2 (en)	1998-06-30
NZ324712A (en)	1999-05-28
NO982651L (no)	1998-06-09
BG102589A (en)	1999-09-30
PL185723B1 (pl)	2003-07-31
JP3123611B2 (ja)	2001-01-15
PE29798A1 (es)	1998-06-11
RU2158264C2 (ru)	2000-10-27
JP2000344741A (ja)	2000-12-12
JP3254205B2 (ja)	2002-02-04
BR9612412A (pt)	1999-07-13
ES2190486T3 (es)	2003-08-01
DE69626220T2 (de)	2003-08-28
KR100275402B1 (ko)	2000-12-15
DE69626220D1 (de)	2003-03-20
NO982651D0 (no)	1998-06-09
MA26417A1 (fr)	2004-12-20
AU1195097A (en)	1997-08-01
IS4760A (is)	1998-05-28
EP0871623B1 (en)	2003-02-12
US6242438B1 (en)	2001-06-05
TNSN96174A1 (fr)	2005-03-15
IL124309A (en)	2002-11-10
DK0871623T3 (da)	2003-03-31
EP0871623A1 (en)	1998-10-21
CA2237189C (en)	2002-09-03
CA2237189A1 (en)	1997-07-17
CZ209398A3 (cs)	1999-04-14

Publication	Publication Date	Title
RU2150468C1 (ru)	2000-06-10	Производные (азетидин-1-илалкил)лактамов, фармацевтическая композиция на их основе и способ лечения человека, при котором заболевание лечат посредством продуцирования антагонистического действия на тахикинин, действующий в человеческом nк1-, nк2- и nк3-рецепторе или в их сочетании
NO311838B1 (no)	2002-02-04	3-Azetidinylalkylpiperidiner eller -pyrrolidiner som takykininantagonister
US20070249589A1 (en)	2007-10-25	Novel diazepan derivatives
EP0862567A1 (en)	1998-09-09	5-azabicyclo(3.1.0)hexylalkyl-2-piperidones and -glutarimides as neurokinin receptor antagonists
US20040132710A1 (en)	2004-07-08	Lactams as tachkinin antagonists
US5846965A (en)	1998-12-08	3-aza and 3-oxa piperidone tachykinin antagonists
WO2010060703A1 (en)	2010-06-03	3-(benzylamino)-pyrrolidine derivatives and their use as nk-3 receptor antagonists
US5741790A (en)	1998-04-21	Azetidines
JP2000119251A (ja)	2000-04-25	複素環式化合物
KR100218626B1 (ko)	1999-09-01	타키키닌 길항물질로서의 (아제티딘-1-일알킬)락탐