NO319782B1 - Pantoprazol-magnesiumdihydrat, medikamenter inneholdende denne og anvendelsen derav - Google Patents

Pantoprazol-magnesiumdihydrat, medikamenter inneholdende denne og anvendelsen derav Download PDF

Info

Publication number: NO319782B1
Authority: NO; Norway
Prior art keywords: pantoprazole; magnesium; magnesium dihydrate; dihydrate; sodium sesquihydrate
Prior art date: 1998-08-18

Application number

NO20010718A

Other languages

English (en)

Norwegian (no)

Other versions

NO20010718L (no

NO20010718D0 (no

Inventor

Bernhard Kohl

Original Assignee

Takeda Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-18

Filing date

2001-02-12

Publication date

2005-09-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7881823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO319782(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-02-12 Application filed by Takeda Gmbh filed Critical Takeda Gmbh

2001-02-12 Publication of NO20010718L publication Critical patent/NO20010718L/no

2001-02-12 Publication of NO20010718D0 publication Critical patent/NO20010718D0/no

2005-09-12 Publication of NO319782B1 publication Critical patent/NO319782B1/no

Links

239000003814 drug Substances 0.000 title claims description 6
-1 Pantoprazole-magnesium dihydrate Chemical class 0.000 title claims description 5
IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims abstract description 29
229960005019 pantoprazole Drugs 0.000 claims abstract description 27
RDRUTBCDIVCMMX-UHFFFAOYSA-N magnesium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide Chemical compound [Mg+2].COC1=CC=NC(CS(=O)C=2[N-]C3=CC=C(OC(F)F)C=C3N=2)=C1OC.COC1=CC=NC(CS(=O)C=2[N-]C3=CC=C(OC(F)F)C=C3N=2)=C1OC RDRUTBCDIVCMMX-UHFFFAOYSA-N 0.000 claims description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
229940079593 drug Drugs 0.000 claims description 5
201000010099 disease Diseases 0.000 claims description 4
230000027119 gastric acid secretion Effects 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 3
230000002265 prevention Effects 0.000 claims description 3
229940000425 combination drug Drugs 0.000 claims 4
239000000546 pharmaceutical excipient Substances 0.000 claims 1
159000000003 magnesium salts Chemical class 0.000 abstract description 10
150000004683 dihydrates Chemical class 0.000 abstract description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
150000001875 compounds Chemical class 0.000 description 11
PWWDEIMGEBPTJL-UHFFFAOYSA-N 1-(pyridin-2-ylmethylsulfinyl)benzimidazole Chemical class C1=NC2=CC=CC=C2N1S(=O)CC1=CC=CC=N1 PWWDEIMGEBPTJL-UHFFFAOYSA-N 0.000 description 6
239000007787 solid Substances 0.000 description 6
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
239000008213 purified water Substances 0.000 description 5
238000000354 decomposition reaction Methods 0.000 description 4
238000003756 stirring Methods 0.000 description 4
CRGZYKWWYNQGEC-UHFFFAOYSA-N magnesium;methanolate Chemical compound [Mg+2].[O-]C.[O-]C CRGZYKWWYNQGEC-UHFFFAOYSA-N 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
YNWDKZIIWCEDEE-UHFFFAOYSA-N pantoprazole sodium Chemical compound [Na+].COC1=CC=NC(CS(=O)C=2[N-]C3=CC=C(OC(F)F)C=C3N=2)=C1OC YNWDKZIIWCEDEE-UHFFFAOYSA-N 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
239000011734 sodium Substances 0.000 description 3
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
239000002253 acid Substances 0.000 description 2
125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 description 2
DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000000034 method Methods 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 description 2
239000000203 mixture Substances 0.000 description 2
229960004048 pantoprazole sodium Drugs 0.000 description 2
239000000843 powder Substances 0.000 description 2
150000003839 salts Chemical group 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
238000003860 storage Methods 0.000 description 2
108091006112 ATPases Proteins 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000004703 alkoxides Chemical class 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036765 blood level Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
229960003174 lansoprazole Drugs 0.000 description 1
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 1
229960002337 magnesium chloride Drugs 0.000 description 1
235000011147 magnesium chloride Nutrition 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229940050906 magnesium chloride hexahydrate Drugs 0.000 description 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
239000000347 magnesium hydroxide Substances 0.000 description 1
229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
229940091250 magnesium supplement Drugs 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229960000381 omeprazole Drugs 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229960005235 piperonyl butoxide Drugs 0.000 description 1
239000003495 polar organic solvent Substances 0.000 description 1
IKNCGYCHMGNBCP-UHFFFAOYSA-N propan-1-olate Chemical compound CCC[O-] IKNCGYCHMGNBCP-UHFFFAOYSA-N 0.000 description 1
229960004157 rabeprazole Drugs 0.000 description 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000012265 solid product Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Manufacture And Refinement Of Metals (AREA)
Detergent Compositions (AREA)
Drying Of Gases (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

NO20010718A 1998-08-18 2001-02-12 Pantoprazol-magnesiumdihydrat, medikamenter inneholdende denne og anvendelsen derav NO319782B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19843413A DE19843413C1 (de)	1998-08-18	1998-08-18	Neue Salzform von Pantoprazol
PCT/EP1999/005928 WO2000010995A1 (en)	1998-08-18	1999-08-12	Novel salt form of pantoprazole

Publications (3)

Publication Number	Publication Date
NO20010718L NO20010718L (no)	2001-02-12
NO20010718D0 NO20010718D0 (no)	2001-02-12
NO319782B1 true NO319782B1 (no)	2005-09-12

Family

ID=7881823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20010718A NO319782B1 (no)	1998-08-18	2001-02-12	Pantoprazol-magnesiumdihydrat, medikamenter inneholdende denne og anvendelsen derav

Country Status (33)

Country	Link
US (2)	US6410569B1 (sk)
EP (1)	EP1105386B1 (sk)
JP (1)	JP2002523411A (sk)
KR (1)	KR100657835B1 (sk)
CN (1)	CN1146558C (sk)
AT (1)	ATE219074T1 (sk)
AU (1)	AU761715B2 (sk)
BG (1)	BG65255B1 (sk)
BR (1)	BR9914288A (sk)
CA (1)	CA2341031C (sk)
CZ (1)	CZ293734B6 (sk)
DE (3)	DE19843413C1 (sk)
DK (1)	DK1105386T3 (sk)
EA (1)	EA004431B1 (sk)
EE (1)	EE04278B1 (sk)
ES (1)	ES2178896T3 (sk)
HK (1)	HK1037616A1 (sk)
HR (1)	HRP20010117B1 (sk)
HU (1)	HU226618B1 (sk)
IL (3)	IL141328A0 (sk)
ME (1)	ME00562A (sk)
MX (1)	MXPA01001758A (sk)
NO (1)	NO319782B1 (sk)
NZ (1)	NZ509761A (sk)
PL (1)	PL198801B1 (sk)
PT (1)	PT1105386E (sk)
RS (1)	RS50071B (sk)
SI (1)	SI1105386T1 (sk)
SK (1)	SK285105B6 (sk)
TR (1)	TR200100287T2 (sk)
UA (1)	UA58605C2 (sk)
WO (1)	WO2000010995A1 (sk)
ZA (1)	ZA200100934B (sk)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19843413C1 (de) *	1998-08-18	2000-03-30	Byk Gulden Lomberg Chem Fab	Neue Salzform von Pantoprazol
MY137726A (en) *	2000-11-22	2009-03-31	Nycomed Gmbh	Freeze-dried pantoprazole preparation and pantoprazole injection
TW200410955A (en) *	2002-07-29	2004-07-01	Altana Pharma Ag	Novel salt of (S)-PANTOPRAZOLE
DE10234617B4 (de) *	2002-07-29	2013-04-04	Nycomed Gmbh	Neues Salz von (S)-Pantoprazol
JP2006514108A (ja) *	2002-12-19	2006-04-27	テバファーマシューティカルインダストリーズリミティド	パントプラゾールナトリウムの固体状態、それらの調製方法、及び公知のパントプラゾールナトリウム水和物の調製方法
US20060235053A1 (en) *	2003-05-06	2006-10-19	Atlanta Pharma Ag	Agents for the treatment of lower abdominal disorders
CL2004000983A1 (es) *	2003-05-08	2005-03-04	Altana Pharma Ag	Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
PE20050150A1 (es) *	2003-05-08	2005-03-22	Altana Pharma Ag	Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
EP1631284A2 (en) *	2003-05-19	2006-03-08	Pliva-Istrazivanje I Razvoj D.D.O.	Solid-state forms of 5-(difluoromethoxy)-2-((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole (pantoprazole) sodium aqua complexes
WO2004111029A2 (en)	2003-06-10	2004-12-23	Teva Pharmaceutical Industries Ltd.	Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
WO2005012289A1 (en) *	2003-07-17	2005-02-10	Altana Pharma Ag	Novel salt of (r) - pantoprazole
CN100457104C (zh) *	2003-07-23	2009-02-04	尼科梅德有限责任公司	质子泵抑制剂的碱性盐
DK1651217T3 (da) *	2003-07-23	2008-06-16	Nycomed Gmbh	Alkalisalte af protonpumpeinhibitorer
CA2554260A1 (en) *	2004-01-28	2005-08-18	Altana Pharma Ag	Calcium, potassium, zinc, lithium and aluminium salts of pantoprazole and (s)-pantoprazole
WO2005074930A1 (en) *	2004-01-28	2005-08-18	Altana Pharma Ag	Pharmaceutical combinations of (s) -pantoprazole with nsaid or corticosteroids
WO2005074931A1 (en) *	2004-01-28	2005-08-18	Altana Pharma Ag	Pharmaceutical combinations comprising (s) -pantoprazole
WO2005074932A1 (en) *	2004-01-28	2005-08-18	Altana Pharma Ag	The use of (s) - pantoprazole magnesium for the treatment of airway disorders
WO2005074898A2 (en) *	2004-01-28	2005-08-18	Altana Pharma Ag	Composition comprising (s) pantoprazole and an antibiotic for treating helicobacter pylori
WO2005077936A1 (en) *	2004-02-11	2005-08-25	Ulkar Kimya Sanayii Ve Ticaret A.S.	Pyridine benzimidazole sulfoxides with high purity
WO2005082888A1 (en) *	2004-03-01	2005-09-09	Milen Merkez Ilac Endustrisi A.S.	Process for the preparation of magnesium salt of omeprazole
SI1746980T1 (sl) *	2004-05-07	2012-03-30	Nycomed Gmbh	Farmacevtska dozirna oblika ki obsega pelete kot tudi postopek za njeno pripravo
WO2007041790A1 (en) *	2005-10-14	2007-04-19	Jon Pty Limited	Salts of proton pump inhibitors and process for preparing same
US20080139623A1 (en)	2006-06-12	2008-06-12	Lilach Hedvati	Amorphous and crystalline forms of pantoprazole magnesium salt
US20080177076A1 (en) *	2006-11-06	2008-07-24	Lilach Hedvanti	Processes for preparing substantially pure pantoprazole magnesium
EP3187494A1 (en) *	2015-12-30	2017-07-05	KRKA, tovarna zdravil, d.d., Novo mesto	Process for the preparation of pantoprazole sodium sesquihydrate
EP3397630B1 (en) *	2015-12-30	2021-05-26	KRKA, tovarna zdravil, d.d., Novo mesto	Process for the preparation of pantoprazole sodium sesquihydrate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
IL75400A (en)	1984-06-16	1988-10-31	Byk Gulden Lomberg Chem Fab	Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) *	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
FI90544C (fi) *	1986-11-13	1994-02-25	Eisai Co Ltd	Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
DE4018642C2 (de) *	1990-06-11	1993-11-25	Byk Gulden Lomberg Chem Fab	Neue Salzform des 5-Difluormethoxy-2-[(3,4-dimethoxy-2-pyridyl) methylsulfinyl]-1H-benzimitazol-Natriumsalzes
YU48263B (sh) *	1991-06-17	1997-09-30	Byk Gulden Lomberg Chemische Fabrik Gmbh.	Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
SE9302396D0 (sv) *	1993-07-09	1993-07-09	Ab Astra	A novel compound form
SE9600070D0 (sv) *	1996-01-08	1996-01-08	Astra Ab	New oral pharmaceutical dosage forms
SE508669C2 (sv) *	1996-04-26	1998-10-26	Astra Ab	Nytt förfarande
DE19843413C1 (de) *	1998-08-18	2000-03-30	Byk Gulden Lomberg Chem Fab	Neue Salzform von Pantoprazol

1998
- 1998-08-18 DE DE19843413A patent/DE19843413C1/de not_active Expired - Fee Related
1999
- 1999-08-12 DK DK99941605T patent/DK1105386T3/da active
- 1999-08-12 NZ NZ509761A patent/NZ509761A/en not_active IP Right Cessation
- 1999-08-12 CN CNB998098000A patent/CN1146558C/zh not_active Expired - Fee Related
- 1999-08-12 KR KR1020017001911A patent/KR100657835B1/ko not_active IP Right Cessation
- 1999-08-12 MX MXPA01001758A patent/MXPA01001758A/es active IP Right Grant
- 1999-08-12 CA CA002341031A patent/CA2341031C/en not_active Expired - Lifetime
- 1999-08-12 US US09/762,303 patent/US6410569B1/en not_active Expired - Lifetime
- 1999-08-12 SK SK236-2001A patent/SK285105B6/sk not_active IP Right Cessation
- 1999-08-12 SI SI9930096T patent/SI1105386T1/xx unknown
- 1999-08-12 EP EP99941605A patent/EP1105386B1/en not_active Expired - Lifetime
- 1999-08-12 WO PCT/EP1999/005928 patent/WO2000010995A1/en active IP Right Grant
- 1999-08-12 IL IL14132899A patent/IL141328A0/xx unknown
- 1999-08-12 DE DE69901840T patent/DE69901840T2/de not_active Expired - Lifetime
- 1999-08-12 HU HU0103257A patent/HU226618B1/hu not_active IP Right Cessation
- 1999-08-12 AU AU55156/99A patent/AU761715B2/en not_active Ceased
- 1999-08-12 PT PT99941605T patent/PT1105386E/pt unknown
- 1999-08-12 EA EA200100208A patent/EA004431B1/ru not_active IP Right Cessation
- 1999-08-12 ES ES99941605T patent/ES2178896T3/es not_active Expired - Lifetime
- 1999-08-12 PL PL345993A patent/PL198801B1/pl unknown
- 1999-08-12 EE EEP200100054A patent/EE04278B1/xx unknown
- 1999-08-12 ME MEP-847/08A patent/ME00562A/xx unknown
- 1999-08-12 RS YUP-113/01A patent/RS50071B/sr unknown
- 1999-08-12 TR TR2001/00287T patent/TR200100287T2/xx unknown
- 1999-08-12 DE DE1999601840 patent/DE122005000049I2/de active Active
- 1999-08-12 JP JP2000566268A patent/JP2002523411A/ja active Pending
- 1999-08-12 CZ CZ2001621A patent/CZ293734B6/cs not_active IP Right Cessation
- 1999-08-12 BR BR9914288-0A patent/BR9914288A/pt not_active Application Discontinuation
- 1999-08-12 IL IL14115799A patent/IL141157A0/xx active IP Right Grant
- 1999-08-12 AT AT99941605T patent/ATE219074T1/de active
- 1999-12-08 UA UA2001021133A patent/UA58605C2/uk unknown
2001
- 2001-01-23 BG BG105173A patent/BG65255B1/bg unknown
- 2001-01-29 IL IL141157A patent/IL141157A/en not_active IP Right Cessation
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- 2001-02-12 NO NO20010718A patent/NO319782B1/no not_active IP Right Cessation
- 2001-02-16 HR HR20010117A patent/HRP20010117B1/xx not_active IP Right Cessation
- 2001-11-20 HK HK01108172A patent/HK1037616A1/xx not_active IP Right Cessation
2002
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Also Published As

Publication number	Publication date
ME00562B (me)	2011-12-20
AU5515699A (en)	2000-03-14
AU761715B2 (en)	2003-06-05
US6410569B1 (en)	2002-06-25
SK2362001A3 (en)	2001-09-11
KR20010072487A (ko)	2001-07-31
PL345993A1 (en)	2002-01-14
CZ293734B6 (cs)	2004-07-14
EE04278B1 (et)	2004-04-15
ATE219074T1 (de)	2002-06-15
IL141157A0 (en)	2002-02-10
KR100657835B1 (ko)	2006-12-15
US6686379B2 (en)	2004-02-03
PT1105386E (pt)	2002-11-29
HK1037616A1 (en)	2002-02-15
DE69901840D1 (de)	2002-07-18
BG65255B1 (bg)	2007-10-31
UA58605C2 (uk)	2003-08-15
IL141157A (en)	2007-06-17
NZ509761A (en)	2003-08-29
CZ2001621A3 (cs)	2001-08-15
HUP0103257A3 (en)	2003-01-28
ES2178896T3 (es)	2003-01-01
MXPA01001758A (es)	2002-04-17
CN1318065A (zh)	2001-10-17
SK285105B6 (sk)	2006-06-01
JP2002523411A (ja)	2002-07-30
ME00562A (en)	2011-12-20
DE122005000049I1 (de)	2006-12-28
DE19843413C1 (de)	2000-03-30
BG105173A (en)	2001-11-30
DE122005000049I2 (de)	2007-03-29
CA2341031C (en)	2006-04-04
SI1105386T1 (en)	2002-12-31
EP1105386A1 (en)	2001-06-13
RS50071B (sr)	2009-01-22
DK1105386T3 (da)	2002-09-30
TR200100287T2 (tr)	2001-07-23
YU11301A (sh)	2003-12-31
PL198801B1 (pl)	2008-07-31
BR9914288A (pt)	2001-06-19
WO2000010995A1 (en)	2000-03-02
CN1146558C (zh)	2004-04-21
NO20010718L (no)	2001-02-12
US20020188008A1 (en)	2002-12-12
EP1105386B1 (en)	2002-06-12
IL141328A0 (en)	2002-03-10
EA004431B1 (ru)	2004-04-29
HRP20010117A2 (en)	2002-02-28
HU226618B1 (en)	2009-04-28
NO20010718D0 (no)	2001-02-12
ZA200100934B (en)	2002-03-04
CA2341031A1 (en)	2000-03-02
DE69901840T2 (de)	2003-05-22
EE200100054A (et)	2002-06-17
HRP20010117B1 (en)	2010-07-31
HUP0103257A2 (hu)	2002-02-28
EA200100208A1 (ru)	2001-08-27

Publication	Publication Date	Title
NO319782B1 (no)	2005-09-12	Pantoprazol-magnesiumdihydrat, medikamenter inneholdende denne og anvendelsen derav
KR101180530B1 (ko)	2012-09-06	제약방법 및 이 방법으로 조제된 화합물
JP3828648B2 (ja)	2006-10-04	２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
JP2007145872A (ja)	2007-06-14	ランソプラゾール安定化方法
RU2313343C2 (ru)	2007-12-27	Комплекс включения s-омепразола (эсомепразола) с циклодекстрином
AU2002344386A1 (en)	2003-05-08	S-omeprazole (esomeprazole) inclusion complex with cyclodextrins
US7683080B2 (en)	2010-03-23	Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
WO2005070426A1 (en)	2005-08-04	Freeze-dried (-)-pantoprazole preparation and (-)-pantoprazole injection
JP4444908B2 (ja)	2010-03-31	２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
ZA200410275B (en)	2006-07-26	Salt of (S)-pantoprazole and its hydrates

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2013-03-25	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: TAKEDA GMBH, DE
2015-03-09	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: TAKEDA GMBH, DE
2019-03-25	MM1K	Lapsed by not paying the annual fees