NO3056203T3 - - Google Patents
Info
- Publication number
- NO3056203T3 NO3056203T3 NO16154533A NO16154533A NO3056203T3 NO 3056203 T3 NO3056203 T3 NO 3056203T3 NO 16154533 A NO16154533 A NO 16154533A NO 16154533 A NO16154533 A NO 16154533A NO 3056203 T3 NO3056203 T3 NO 3056203T3
- Authority
- NO
- Norway
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
- A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32643710P | 2010-04-21 | 2010-04-21 | |
US42182410P | 2010-12-10 | 2010-12-10 | |
EP11720340.6A EP2560645B1 (en) | 2010-04-21 | 2011-04-21 | Conjugates of cc-1065 analogs and bifunctional linkers |
Publications (1)
Publication Number | Publication Date |
---|---|
NO3056203T3 true NO3056203T3 (ru) | 2018-05-12 |
Family
ID=44343209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO16154533A NO3056203T3 (ru) | 2010-04-21 | 2011-04-21 |
Country Status (23)
Country | Link |
---|---|
US (3) | US9629924B2 (ru) |
EP (3) | EP2560645B1 (ru) |
JP (2) | JP6009434B2 (ru) |
KR (3) | KR20170027880A (ru) |
CN (1) | CN106749665B (ru) |
AU (2) | AU2011243294C1 (ru) |
BR (1) | BR112012026953A8 (ru) |
CA (2) | CA2796712C (ru) |
CY (3) | CY1118072T1 (ru) |
DK (3) | DK2560645T3 (ru) |
ES (3) | ES2660428T3 (ru) |
HR (3) | HRP20161339T1 (ru) |
HU (3) | HUE036912T2 (ru) |
LT (3) | LT3108886T (ru) |
MX (1) | MX336853B (ru) |
NO (1) | NO3056203T3 (ru) |
PL (3) | PL2560645T3 (ru) |
PT (3) | PT3108886T (ru) |
RU (2) | RU2578719C9 (ru) |
TR (1) | TR201802539T4 (ru) |
UA (1) | UA112291C2 (ru) |
WO (1) | WO2011133039A2 (ru) |
ZA (1) | ZA201208282B (ru) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1994055T3 (da) | 2006-03-10 | 2014-08-25 | Wyeth Llc | Anti-5t4-antistoffer og anvendelser deraf |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
US8889868B2 (en) | 2008-11-03 | 2014-11-18 | Syntarga Bv | CC-1065 analogs and their conjugates |
PL2560645T3 (pl) | 2010-04-21 | 2017-01-31 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
RS53818B1 (en) | 2012-10-12 | 2015-06-30 | Spirogen Sàrl | PIROLOBENZODIAZEPINI I NJIHOVI conjugated |
WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
US9649390B2 (en) | 2013-03-13 | 2017-05-16 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
TWI680766B (zh) * | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
AU2014307080B2 (en) | 2013-08-12 | 2018-06-07 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1H-benzo(E)indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
MX2016007578A (es) | 2013-12-16 | 2016-10-03 | Genentech Inc | Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento. |
JP6224268B2 (ja) * | 2014-01-10 | 2017-11-01 | シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. | 子宮内膜癌の治療において使用するためのデュオカルマイシンadc |
RU2769700C2 (ru) | 2014-01-10 | 2022-04-05 | Байондис Б.В. | Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo |
ES2687225T3 (es) | 2014-01-10 | 2018-10-24 | Synthon Biopharmaceuticals B.V. | Método de purificación de conjugados anticuerpo-fármaco unidos a Cys |
SG11201609372UA (en) | 2014-05-22 | 2016-12-29 | Synthon Biopharmaceuticals Bv | Site-specific conjugation of linker drugs to antibodies and resulting adcs |
PL3152191T3 (pl) | 2014-06-05 | 2019-10-31 | Synthon Biopharmaceuticals Bv | Ulepszony sposób wytwarzania proleków duokarmycyny |
BR112016029860A2 (pt) | 2014-06-20 | 2017-10-24 | Abgenomics Int Inc | conjugados de anticorpo antirreceptor alfa de folato (fra)-fármaco e métodos de uso dos mesmos |
SG11201610468XA (en) * | 2014-06-20 | 2017-01-27 | Abgenomics Internat Inc | Her2 antibody-drug conjugates |
CA2954934C (en) | 2014-06-30 | 2023-09-26 | Glykos Finland Oy | Drug derivative and conjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CN107847449B (zh) | 2015-07-10 | 2021-04-30 | 拜奥迪斯私人有限公司 | 包含抗体-倍癌霉素药物缀合物的组合物 |
BR112018005494A2 (pt) | 2015-09-22 | 2018-10-09 | Synthon Biopharmaceuticals Bv | composto, composição farmacêutica, e, método de tratamento de um paciente com uma doença. |
EP3165237B1 (en) | 2015-11-03 | 2018-12-19 | Industrial Technology Research Institute | Antibody-drug conjugate (adc) and method for forming the same |
CA3005294A1 (en) * | 2015-11-24 | 2017-06-01 | Synthon Biopharmaceuticals B.V. | Anti-5t4 antibodies and antibody-drug conjugates |
WO2017120534A1 (en) | 2016-01-08 | 2017-07-13 | Bioalliance C.V. | Tetravalent anti-psgl-1 antibodies and uses thereof |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
EP3458100B1 (en) | 2016-02-12 | 2020-07-01 | Byondis B.V | Selective reduction of cysteine-engineered antibodies |
WO2017180813A1 (en) | 2016-04-15 | 2017-10-19 | Macrogenics, Inc. | Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
ES2902179T3 (es) * | 2016-08-19 | 2022-03-25 | Bristol Myers Squibb Co | Compuestos de seco-ciclopropapirroloindol, conjugados de anticuerpo-fármaco de los mismos y métodos de elaboración y uso |
RU2755899C2 (ru) | 2016-10-11 | 2021-09-22 | Байондис Б.В. | Нелинейные саморасщепляющиеся линкеры и их конъюгаты |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
US10815194B2 (en) | 2016-11-14 | 2020-10-27 | Byondis B.V. | Process for the preparation of mono-protected α,ω-diamino alkanes |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
WO2018146189A1 (en) | 2017-02-08 | 2018-08-16 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
HRP20221063T1 (hr) | 2017-04-18 | 2022-11-11 | Medimmune Limited | Konjugati pirolobenzodiazepina |
WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
RU2771310C2 (ru) * | 2017-05-23 | 2022-04-29 | Байондис Б. В. | Способ двойной конъюгации для получения конъюгатов антитело-лекарственное средство |
SMT202200225T1 (it) | 2017-08-18 | 2022-07-21 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
JP7381478B2 (ja) | 2017-10-23 | 2023-11-15 | マブリンク ビオシオンス | 単一分子量ポリサルコシンを含むリガンド-薬物-複合体 |
HRP20211435T1 (hr) * | 2017-11-24 | 2022-01-07 | Byondis B.V. | Poboljšan postupak sinteze linkerskog lijeka vc-seco |
AU2018371271A1 (en) | 2017-11-27 | 2020-06-11 | Purdue Pharma L.P. | Humanized antibodies targeting human tissue factor |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CA3116234A1 (en) | 2018-10-15 | 2020-04-23 | Merck Patent Gmbh | Combination therapy utilizing dna alkylating agents and atr inhibitors |
LT3876997T (lt) | 2018-11-09 | 2022-11-10 | Byondis B.V. | Filtruojamos, duokarmiciną sudėtyje turinčio antikūno-vaisto konjugato kompozicijos ir susiję būdai |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
EP4100024A1 (en) | 2020-02-06 | 2022-12-14 | Byondis B.V. | Combination containing a duocarmycin derivative-comprising antibody-drug conjugate and thiosulfate |
BR112023000174A2 (pt) | 2020-07-06 | 2023-01-31 | Byondis Bv | Composto ligante-fármaco, conjugado anticorpo-fármaco, composição farmacêutica, e, uso de um composto |
US20220008511A1 (en) * | 2020-07-12 | 2022-01-13 | Henry J. Smith | Tumor treatment using cytokines and cancer drugs |
US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
IL306142A (en) | 2021-04-08 | 2023-11-01 | Byondis Bv | ANTI-C-MET antibodies and antibody conjugates |
EP4362982A1 (en) | 2021-06-28 | 2024-05-08 | Byondis B.V. | Conjugates comprising phosphoantigens and their use in therapy |
EP4457229A1 (en) | 2021-12-30 | 2024-11-06 | Byondis B.V. | Antifolate linker-drugs and antibody-drug conjugates |
WO2023222580A1 (en) | 2022-05-16 | 2023-11-23 | Byondis B.V. | Novel masked antibodies |
WO2024133374A1 (en) | 2022-12-22 | 2024-06-27 | Byondis B.V. | Novel linker drugs comprising phosphoantigens, novel conjugates and their use in therapy |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0065360A3 (en) | 1981-05-12 | 1983-08-10 | Schlumberger Electronics (U.K.) Limited | Parallel motion displacement transducers |
CA1238907A (en) | 1984-02-21 | 1988-07-05 | Robert C. Kelly | 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds |
US4771128A (en) | 1986-10-10 | 1988-09-13 | Cetus Corporation | Method of purifying toxin conjugates using hydrophobic interaction chromatography |
MX9203200A (es) | 1986-12-19 | 1992-09-01 | Upjohn Co | Analogos de cc. 1065 novedosos. |
US5541339A (en) | 1988-09-12 | 1996-07-30 | The Upjohn Company | CC-1065 analogs having two CPI subunits |
CA2078118C (en) * | 1990-04-25 | 1999-11-16 | Paul A. Aristoff | Cc-1065 analogs |
DE69231123T2 (de) | 1992-03-25 | 2001-02-15 | Immunogen Inc | Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065 |
JP3514490B2 (ja) * | 1992-08-21 | 2004-03-31 | 杏林製薬株式会社 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
JP3565559B2 (ja) * | 1994-04-01 | 2004-09-15 | 協和醗酵工業株式会社 | Dc−89誘導体 |
JPH07309761A (ja) | 1994-05-20 | 1995-11-28 | Kyowa Hakko Kogyo Co Ltd | デュオカルマイシン誘導体の安定化法 |
US5502068A (en) | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
DE19503320A1 (de) | 1995-02-02 | 1996-08-08 | Boehringer Mannheim Gmbh | Neue Benzodiazepinkonjugate |
US5646298A (en) | 1995-06-07 | 1997-07-08 | Procoron, Inc. | Cyclopropylindole prodrugs |
GB9516943D0 (en) | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
CA2233936A1 (en) | 1995-10-03 | 1997-04-10 | The Scripps Research Institute | Cbi analogs of cc-1065 and the duocarmycins |
CA2246783C (en) | 1996-03-08 | 2006-07-11 | The Scripps Research Institute | Mcbi analogs of cc-1065 and the duocarmycins |
US5843937A (en) | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
WO1997045411A1 (en) | 1996-05-31 | 1997-12-04 | The Scripps Research Institute | Analogs of cc-1065 and the duocarmycins |
DE69734722T2 (de) * | 1996-09-12 | 2006-07-20 | Auckland Uniservices Ltd. | Kondensierte n-acylindole als antitumormittel |
WO1998025900A1 (fr) | 1996-12-13 | 1998-06-18 | Shionogi & Co., Ltd. | Composes presentant une activite antitumorale |
GB9625913D0 (en) | 1996-12-13 | 1997-01-29 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their seco precursors,and their use as prodrugs |
EP0983248B1 (en) | 1997-05-22 | 2004-07-14 | The Scripps Research Institute | Analogs of duocarmycin and cc-1065 |
EP1042285A4 (en) | 1997-10-14 | 2002-11-20 | Scripps Research Inst | iso-CBI AND iso-CI ANALOGA BY CC-1065 AND DUOCARMYCINE |
US20030036629A1 (en) | 1997-12-12 | 2003-02-20 | Barry Foster | Novel tgf-beta protein purification methods |
ATE279390T1 (de) | 2000-05-02 | 2004-10-15 | Tietze Lutz F Prof Dr | Neue prodrugs von 6-hydroxy-2,3-dihydro-1h- indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo 3,2- e)indolen und 5-hydroxy-1,2-dihydro-3h-benzo e)indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro- benzo f)chinolin-derivaten für eine selektive krebstherapie |
WO2001083482A1 (en) | 2000-05-03 | 2001-11-08 | The Scripps Research Institute | Dna alkylating agent and activation thereof |
US6660742B2 (en) * | 2000-09-19 | 2003-12-09 | Taiho Pharmaceutical Co. Ltd. | Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins |
EP1363908A4 (en) * | 2001-01-24 | 2004-05-06 | Auckland Uniservices Ltd | ANTI-CANCER COMPLEXES 2,3-DIHYDRO-1H-PYRROLO 3,2-F] COBALT AND CHROME QUINOLINE |
ATE361750T1 (de) | 2001-02-22 | 2007-06-15 | Univ London Pharmacy | Indoline und tetrahydro-chinoline als prodrugs zur tumorbehandlung |
JP2004529887A (ja) | 2001-02-22 | 2004-09-30 | スクール オブ ファーマシー, ユニヴァーシティ オブ ロンドン | 腫瘍治療のためのプロドラッグとしてのピロロ−インドールおよびピロロ−キノリン誘導体 |
JP4862120B2 (ja) | 2001-02-22 | 2012-01-25 | ユニヴァーシティ オブ ブラッドフォード | 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体 |
EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
US6989452B2 (en) | 2001-05-31 | 2006-01-24 | Medarex, Inc. | Disulfide prodrugs and linkers and stabilizers useful therefor |
US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
EP1423110A4 (en) | 2001-09-07 | 2005-04-27 | Scripps Research Inst | CBI ANALOGUE OF CC-1065 AND DUOCARMYCINES |
US6756397B2 (en) * | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
US7235578B2 (en) | 2002-05-17 | 2007-06-26 | Auckland Uniservices Limited | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom |
EP1560599A1 (en) | 2002-11-14 | 2005-08-10 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
TWI405573B (zh) | 2003-01-27 | 2013-08-21 | Endocyte Inc | 維生素-受體結合性藥物輸送共軛物中間物及製備方法 |
WO2004069201A2 (en) * | 2003-02-03 | 2004-08-19 | Medlogics Device Corporation | Compounds useful in coating stents to prevent and treat stenosis and restenosis |
CA2516455C (en) | 2003-02-20 | 2012-05-01 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
US20050026987A1 (en) | 2003-05-13 | 2005-02-03 | The Scripps Research Institute | CBI analogues of the duocarmycins and CC-1065 |
WO2005032594A2 (en) * | 2003-10-03 | 2005-04-14 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Alkylators linked to polyamides as dna binding agents |
US7282590B2 (en) | 2004-02-12 | 2007-10-16 | The Research Foundation Of State University Of New York | Drug conjugates |
ES2533695T3 (es) | 2004-03-02 | 2015-04-14 | Seattle Genetics, Inc. | Anticuerpos cargados parcialmente y métodos para su conjugación |
AU2005238015A1 (en) | 2004-04-21 | 2005-11-10 | Alza Corporation | Polymer conjugate releasable under mild thiolytic conditions |
US20050239864A1 (en) | 2004-04-23 | 2005-10-27 | Yuqiang Wang | Novel tumor-selective chemotherapeutic agents |
AU2005244980B2 (en) | 2004-05-19 | 2011-09-15 | E. R. Squibb & Sons, L.L.C. | Chemical linkers and conjugates thereof |
KR20070037719A (ko) | 2004-06-30 | 2007-04-06 | 노파르티스 아게 | 항종양제로서의 항체와 듀오카르마이신 유도체의컨쥬게이트 |
WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
ES2669510T3 (es) | 2004-09-23 | 2018-05-28 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
CA2581930A1 (en) | 2004-09-27 | 2006-04-06 | Jane Trepel | Modulating mxa expression |
NZ536107A (en) | 2004-10-22 | 2007-06-29 | Auckland Uniservices Ltd | Nitrobenzindoles and their use in cancer therapy |
JP2008531542A (ja) | 2005-02-24 | 2008-08-14 | ファイザー・プロダクツ・インク | 抗癌剤として有用な二環式複素芳香族誘導体 |
FR2884252B1 (fr) * | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
EP1909846B1 (en) | 2005-08-05 | 2018-12-26 | Syntarga B.V. | Triazole-containing releasable linkers, conjugates comprising the same and processes for their preparation |
ES2416136T3 (es) | 2005-09-26 | 2013-07-30 | Medarex, Inc. | Conjugados de anticuerpo-fármaco y su uso |
SI1940789T1 (sl) * | 2005-10-26 | 2012-03-30 | Medarex Inc | Postopki in spojine za pripravo cc analogov |
CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
RU2489423C2 (ru) | 2006-02-02 | 2013-08-10 | Синтарга Б.В. | Водорастворимые аналоги сс-1065 и их конъюгаты |
EP1832577A1 (en) * | 2006-03-07 | 2007-09-12 | Sanofi-Aventis | Improved prodrugs of CC-1065 analogs |
CA3069091C (en) | 2006-11-01 | 2021-09-14 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
IN2009KN02404A (ru) * | 2006-12-14 | 2015-08-07 | Medarex Inc | |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
US8664407B2 (en) | 2007-02-21 | 2014-03-04 | Medarex, LLC | Chemical linkers with single amino acids and conjugates thereof |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
US8680293B2 (en) | 2007-08-01 | 2014-03-25 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
WO2009064908A1 (en) | 2007-11-13 | 2009-05-22 | The Scripps Research Institute | Cbi derivatives subject to reductive activation |
CA2706926A1 (en) | 2007-11-30 | 2009-06-11 | Bristol-Myers Squibb Company | Anti-b7h4 monoclonal antibody-drug conjugate and methods of use |
AU2008334076A1 (en) | 2007-11-30 | 2009-06-11 | Bristol-Myers Squibb Company | Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (PTK7) |
CN101951960A (zh) | 2007-11-30 | 2011-01-19 | 百时美施贵宝公司 | 抗rg-1抗体之偶联物 |
US20090162372A1 (en) | 2007-11-30 | 2009-06-25 | Medarex, Inc. | Fibronectin ed-b antibodies, conjugates thereof, and methods of use |
DK2281006T3 (da) | 2008-04-30 | 2017-11-06 | Immunogen Inc | Tværbindingsmidler og anvendelser deraf |
NZ571028A (en) | 2008-09-03 | 2011-01-28 | Auckland Uniservices Ltd | Nitrobenzindole compounds and their use in cancer treatment |
WO2010033733A1 (en) | 2008-09-17 | 2010-03-25 | Endocyte, Inc. | Folate receptor binding conjugates of antifolates |
US8889868B2 (en) | 2008-11-03 | 2014-11-18 | Syntarga Bv | CC-1065 analogs and their conjugates |
US8507195B2 (en) | 2009-08-20 | 2013-08-13 | The Regents Of The University Of Colorado | MiRNAs dysregulated in triple-negative breast cancer |
PL2560645T3 (pl) | 2010-04-21 | 2017-01-31 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
US9958455B2 (en) | 2011-09-29 | 2018-05-01 | Seattle Genetics, Inc. | Intact mass determination of protein conjugated agent compounds |
UA123092C2 (uk) | 2011-10-14 | 2021-02-17 | Дженентек, Інк. | Спосіб неоад'ювантного лікування her2-позитивного раку молочної залози на ранній стадії у пацієнта |
ES2721882T3 (es) | 2011-12-23 | 2019-08-06 | Pfizer | Regiones constantes de anticuerpo modificadas por ingeniería genética para conjugación específica de sitio y procedimientos y usos de las mismas |
JP6224268B2 (ja) | 2014-01-10 | 2017-11-01 | シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. | 子宮内膜癌の治療において使用するためのデュオカルマイシンadc |
ES2687225T3 (es) | 2014-01-10 | 2018-10-24 | Synthon Biopharmaceuticals B.V. | Método de purificación de conjugados anticuerpo-fármaco unidos a Cys |
RU2769700C2 (ru) | 2014-01-10 | 2022-04-05 | Байондис Б.В. | Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo |
SG11201609372UA (en) | 2014-05-22 | 2016-12-29 | Synthon Biopharmaceuticals Bv | Site-specific conjugation of linker drugs to antibodies and resulting adcs |
PL3152191T3 (pl) | 2014-06-05 | 2019-10-31 | Synthon Biopharmaceuticals Bv | Ulepszony sposób wytwarzania proleków duokarmycyny |
EP3197919A1 (en) | 2014-09-22 | 2017-08-02 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
-
2011
- 2011-04-21 PL PL11720340T patent/PL2560645T3/pl unknown
- 2011-04-21 ES ES16154533.0T patent/ES2660428T3/es active Active
- 2011-04-21 JP JP2013506105A patent/JP6009434B2/ja active Active
- 2011-04-21 EP EP11720340.6A patent/EP2560645B1/en active Active
- 2011-04-21 LT LTEP16176625.8T patent/LT3108886T/lt unknown
- 2011-04-21 CA CA2796712A patent/CA2796712C/en active Active
- 2011-04-21 UA UAA201213259A patent/UA112291C2/uk unknown
- 2011-04-21 KR KR1020177005864A patent/KR20170027880A/ko active Application Filing
- 2011-04-21 DK DK11720340.6T patent/DK2560645T3/en active
- 2011-04-21 NO NO16154533A patent/NO3056203T3/no unknown
- 2011-04-21 PL PL16176625T patent/PL3108886T3/pl unknown
- 2011-04-21 KR KR1020187006266A patent/KR101901555B1/ko active IP Right Grant
- 2011-04-21 PT PT161766258T patent/PT3108886T/pt unknown
- 2011-04-21 MX MX2012012176A patent/MX336853B/es active IP Right Grant
- 2011-04-21 PT PT117203406T patent/PT2560645T/pt unknown
- 2011-04-21 CA CA2956934A patent/CA2956934C/en active Active
- 2011-04-21 EP EP16176625.8A patent/EP3108886B1/en active Active
- 2011-04-21 CN CN201611090112.6A patent/CN106749665B/zh active Active
- 2011-04-21 EP EP16154533.0A patent/EP3056203B1/en active Active
- 2011-04-21 PT PT161545330T patent/PT3056203T/pt unknown
- 2011-04-21 HU HUE16154533A patent/HUE036912T2/hu unknown
- 2011-04-21 DK DK16176625.8T patent/DK3108886T3/da active
- 2011-04-21 LT LTEP11720340.6T patent/LT2560645T/lt unknown
- 2011-04-21 LT LTEP16154533.0T patent/LT3056203T/lt unknown
- 2011-04-21 ES ES16176625T patent/ES2815678T3/es active Active
- 2011-04-21 ES ES11720340.6T patent/ES2594952T3/es active Active
- 2011-04-21 PL PL16154533T patent/PL3056203T3/pl unknown
- 2011-04-21 US US13/642,847 patent/US9629924B2/en active Active
- 2011-04-21 RU RU2012149448/04A patent/RU2578719C9/ru active
- 2011-04-21 AU AU2011243294A patent/AU2011243294C1/en active Active
- 2011-04-21 WO PCT/NL2011/050278 patent/WO2011133039A2/en active Application Filing
- 2011-04-21 KR KR1020127030506A patent/KR101747478B1/ko active IP Right Grant
- 2011-04-21 HU HUE16176625A patent/HUE050508T2/hu unknown
- 2011-04-21 HU HUE11720340A patent/HUE030846T2/en unknown
- 2011-04-21 RU RU2016101244A patent/RU2730502C2/ru active
- 2011-04-21 DK DK16154533.0T patent/DK3056203T3/da active
- 2011-04-21 BR BR112012026953A patent/BR112012026953A8/pt not_active Application Discontinuation
- 2011-04-21 TR TR2018/02539T patent/TR201802539T4/tr unknown
-
2012
- 2012-11-05 ZA ZA2012/08282A patent/ZA201208282B/en unknown
-
2015
- 2015-08-13 AU AU2015213336A patent/AU2015213336B2/en active Active
-
2016
- 2016-04-07 JP JP2016077272A patent/JP6193433B2/ja active Active
- 2016-10-06 CY CY20161100997T patent/CY1118072T1/el unknown
- 2016-10-13 HR HRP20161339TT patent/HRP20161339T1/hr unknown
-
2017
- 2017-03-17 US US15/461,569 patent/US20180147289A9/en not_active Abandoned
- 2017-03-17 US US15/461,560 patent/US11052155B2/en active Active
-
2018
- 2018-02-05 HR HRP20180209TT patent/HRP20180209T1/hr unknown
- 2018-02-06 CY CY20181100146T patent/CY1119893T1/el unknown
-
2020
- 2020-08-20 CY CY20201100778T patent/CY1124632T1/el unknown
- 2020-09-10 HR HRP20201446TT patent/HRP20201446T8/hr unknown