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NO20062892L - 7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer - Google Patents

7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer

Info

Publication number
NO20062892L
NO20062892L NO20062892A NO20062892A NO20062892L NO 20062892 L NO20062892 L NO 20062892L NO 20062892 A NO20062892 A NO 20062892A NO 20062892 A NO20062892 A NO 20062892A NO 20062892 L NO20062892 L NO 20062892L
Authority
NO
Norway
Prior art keywords
quinoxalinones
quinolinones
phenylalkyl
adp
ribose
Prior art date
Application number
NO20062892A
Other languages
English (en)
Other versions
NO337252B1 (no
Inventor
Walter Boudewijn Leopo Wouters
Jerome Emile George Guillemont
Jacobus Alphonsus Josephus Dun
Maria Victorina Francis Somers
Dominique Jean-Pierre Mabire
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20062892L publication Critical patent/NO20062892L/no
Publication of NO337252B1 publication Critical patent/NO337252B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel (I), deres anvendelse som PARP-inhibitorer samt farmasøytiske sammensetninger omfattende forbindelsene med formel (I) hvori n, R1, R2, R3, R4, R5, R6 og X har definerte betydninger.
NO20062892A 2003-11-20 2006-06-20 7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer NO337252B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03078650 2003-11-20
PCT/EP2004/013162 WO2005054209A1 (en) 2003-11-20 2004-11-18 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-­ribose) polymerase inhibitors

Publications (2)

Publication Number Publication Date
NO20062892L true NO20062892L (no) 2006-08-09
NO337252B1 NO337252B1 (no) 2016-02-22

Family

ID=34639291

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062892A NO337252B1 (no) 2003-11-20 2006-06-20 7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer

Country Status (19)

Country Link
US (2) US7928104B2 (no)
EP (1) EP1709011B1 (no)
JP (1) JP4864717B2 (no)
KR (1) KR101118644B1 (no)
CN (1) CN1882549B (no)
AU (1) AU2004295057B2 (no)
BR (1) BRPI0416817A (no)
CA (1) CA2546002C (no)
EA (1) EA011211B1 (no)
ES (1) ES2551027T3 (no)
HK (1) HK1100774A1 (no)
IL (1) IL175756A (no)
MX (1) MXPA06005686A (no)
NO (1) NO337252B1 (no)
NZ (1) NZ546990A (no)
SG (1) SG150534A1 (no)
UA (1) UA91002C2 (no)
WO (1) WO2005054209A1 (no)
ZA (1) ZA200604076B (no)

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AU2004295057A1 (en) 2005-06-16
UA91002C2 (ru) 2010-06-25
EA200601007A1 (ru) 2006-10-27
IL175756A (en) 2013-03-24
MXPA06005686A (es) 2006-08-17
AU2004295057B2 (en) 2010-11-25
US8524714B2 (en) 2013-09-03
CA2546002A1 (en) 2005-06-16
EA011211B1 (ru) 2009-02-27
WO2005054209A1 (en) 2005-06-16
NZ546990A (en) 2010-03-26
KR20060111532A (ko) 2006-10-27
CA2546002C (en) 2012-09-18
KR101118644B1 (ko) 2012-03-06
BRPI0416817A (pt) 2007-03-06
IL175756A0 (en) 2006-09-05
ZA200604076B (en) 2007-09-26
CN1882549B (zh) 2011-02-23
JP2007513087A (ja) 2007-05-24
ES2551027T3 (es) 2015-11-13
US7928104B2 (en) 2011-04-19
US20080249099A1 (en) 2008-10-09
NO337252B1 (no) 2016-02-22
SG150534A1 (en) 2009-03-30
CN1882549A (zh) 2006-12-20
HK1100774A1 (en) 2007-09-28
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EP1709011B1 (en) 2015-07-29
US20110230492A1 (en) 2011-09-22

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