NO20062892L - 7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer - Google Patents
7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorerInfo
- Publication number
- NO20062892L NO20062892L NO20062892A NO20062892A NO20062892L NO 20062892 L NO20062892 L NO 20062892L NO 20062892 A NO20062892 A NO 20062892A NO 20062892 A NO20062892 A NO 20062892A NO 20062892 L NO20062892 L NO 20062892L
- Authority
- NO
- Norway
- Prior art keywords
- quinoxalinones
- quinolinones
- phenylalkyl
- adp
- ribose
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer forbindelser med formel (I), deres anvendelse som PARP-inhibitorer samt farmasøytiske sammensetninger omfattende forbindelsene med formel (I) hvori n, R1, R2, R3, R4, R5, R6 og X har definerte betydninger.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03078650 | 2003-11-20 | ||
PCT/EP2004/013162 WO2005054209A1 (en) | 2003-11-20 | 2004-11-18 | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20062892L true NO20062892L (no) | 2006-08-09 |
NO337252B1 NO337252B1 (no) | 2016-02-22 |
Family
ID=34639291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20062892A NO337252B1 (no) | 2003-11-20 | 2006-06-20 | 7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer |
Country Status (19)
Country | Link |
---|---|
US (2) | US7928104B2 (no) |
EP (1) | EP1709011B1 (no) |
JP (1) | JP4864717B2 (no) |
KR (1) | KR101118644B1 (no) |
CN (1) | CN1882549B (no) |
AU (1) | AU2004295057B2 (no) |
BR (1) | BRPI0416817A (no) |
CA (1) | CA2546002C (no) |
EA (1) | EA011211B1 (no) |
ES (1) | ES2551027T3 (no) |
HK (1) | HK1100774A1 (no) |
IL (1) | IL175756A (no) |
MX (1) | MXPA06005686A (no) |
NO (1) | NO337252B1 (no) |
NZ (1) | NZ546990A (no) |
SG (1) | SG150534A1 (no) |
UA (1) | UA91002C2 (no) |
WO (1) | WO2005054209A1 (no) |
ZA (1) | ZA200604076B (no) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2670349T3 (es) * | 2003-11-20 | 2018-05-30 | Janssen Pharmaceutica Nv | 2-Quinolinonas y 2-quinoxalinonas sustituidas con 6-alquenilo y 6-fenilalquilo como inhibidores de poli(ADP-ribosa) polimerasa |
JP4864717B2 (ja) * | 2003-11-20 | 2012-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ(adp−リボース)ポリメラーゼインヒビターとしての7−フェニルアルキル置換2−キノリノンおよび2−キノキサリノン |
AU2004295058B9 (en) | 2003-11-20 | 2011-06-30 | Janssen Pharmaceutica N.V. | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
EA010488B1 (ru) * | 2003-12-05 | 2008-10-30 | Янссен Фармацевтика Н.В. | 6-замещённые 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли (адф-рибоза) полимеразы |
CA2553269C (en) * | 2004-01-23 | 2012-07-10 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
SG154432A1 (en) | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Quinazolinedione derivatives as parp inhibitors |
KR101211950B1 (ko) | 2004-06-30 | 2012-12-13 | 얀센 파마슈티카 엔.브이. | Parp 저해제로서의 프탈아진 유도체 |
NZ551680A (en) | 2004-06-30 | 2010-02-26 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as PARP inhibitors |
KR20080035630A (ko) | 2005-07-18 | 2008-04-23 | 바이파 사이언스 인코포레이티드 | 암의 치료 |
JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
CN101522609A (zh) | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
CN102379884A (zh) | 2006-09-05 | 2012-03-21 | 彼帕科学公司 | Parp抑制剂对脂肪酸合成的抑制及其治疗方法 |
CA2678248C (en) | 2007-03-08 | 2016-06-28 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp and tank inhibitors |
US8404713B2 (en) * | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
CN101917982B (zh) | 2007-11-12 | 2013-03-20 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌 |
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WO2013158664A2 (en) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
JP6457696B2 (ja) | 2015-07-23 | 2019-01-23 | アンスティテュ・キュリInstitut Curie | 癌を処置するためのDbait分子とPARPインヒビターとの組合せの使用 |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
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WO2019175132A1 (en) | 2018-03-13 | 2019-09-19 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
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NZ551680A (en) | 2004-06-30 | 2010-02-26 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as PARP inhibitors |
KR101211950B1 (ko) | 2004-06-30 | 2012-12-13 | 얀센 파마슈티카 엔.브이. | Parp 저해제로서의 프탈아진 유도체 |
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AU2006241825A1 (en) | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | Cyanopyridine derivative and use thereof as medicine |
WO2007025009A2 (en) | 2005-08-24 | 2007-03-01 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
ATE555091T1 (de) | 2006-02-03 | 2012-05-15 | Bionomics Ltd | Substituierte benzofurane, benzothiophene, benzoselenophene und indole und ihre verwendung als tubulinpolymerisationsinhibitoren |
CN101421268B (zh) | 2006-02-15 | 2016-01-06 | Abbvie公司 | 作为有效parp抑制剂的吡唑并喹诺酮 |
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-
2004
- 2004-11-18 JP JP2006540337A patent/JP4864717B2/ja not_active Expired - Fee Related
- 2004-11-18 UA UAA200603547A patent/UA91002C2/ru unknown
- 2004-11-18 NZ NZ546990A patent/NZ546990A/en not_active IP Right Cessation
- 2004-11-18 BR BRPI0416817-8A patent/BRPI0416817A/pt not_active Application Discontinuation
- 2004-11-18 EA EA200601007A patent/EA011211B1/ru not_active IP Right Cessation
- 2004-11-18 AU AU2004295057A patent/AU2004295057B2/en not_active Ceased
- 2004-11-18 CN CN2004800342874A patent/CN1882549B/zh not_active Expired - Fee Related
- 2004-11-18 ES ES04819600.0T patent/ES2551027T3/es not_active Expired - Lifetime
- 2004-11-18 MX MXPA06005686A patent/MXPA06005686A/es active IP Right Grant
- 2004-11-18 WO PCT/EP2004/013162 patent/WO2005054209A1/en active Application Filing
- 2004-11-18 CA CA2546002A patent/CA2546002C/en not_active Expired - Fee Related
- 2004-11-18 US US10/595,882 patent/US7928104B2/en not_active Expired - Fee Related
- 2004-11-18 SG SG200901198-2A patent/SG150534A1/en unknown
- 2004-11-18 EP EP04819600.0A patent/EP1709011B1/en not_active Expired - Lifetime
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2006
- 2006-05-18 IL IL175756A patent/IL175756A/en not_active IP Right Cessation
- 2006-05-19 ZA ZA200604076A patent/ZA200604076B/en unknown
- 2006-05-25 KR KR1020067010200A patent/KR101118644B1/ko not_active IP Right Cessation
- 2006-06-20 NO NO20062892A patent/NO337252B1/no not_active IP Right Cessation
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2007
- 2007-06-04 HK HK07105886.9A patent/HK1100774A1/xx not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
JP4864717B2 (ja) | 2012-02-01 |
AU2004295057A1 (en) | 2005-06-16 |
UA91002C2 (ru) | 2010-06-25 |
EA200601007A1 (ru) | 2006-10-27 |
IL175756A (en) | 2013-03-24 |
MXPA06005686A (es) | 2006-08-17 |
AU2004295057B2 (en) | 2010-11-25 |
US8524714B2 (en) | 2013-09-03 |
CA2546002A1 (en) | 2005-06-16 |
EA011211B1 (ru) | 2009-02-27 |
WO2005054209A1 (en) | 2005-06-16 |
NZ546990A (en) | 2010-03-26 |
KR20060111532A (ko) | 2006-10-27 |
CA2546002C (en) | 2012-09-18 |
KR101118644B1 (ko) | 2012-03-06 |
BRPI0416817A (pt) | 2007-03-06 |
IL175756A0 (en) | 2006-09-05 |
ZA200604076B (en) | 2007-09-26 |
CN1882549B (zh) | 2011-02-23 |
JP2007513087A (ja) | 2007-05-24 |
ES2551027T3 (es) | 2015-11-13 |
US7928104B2 (en) | 2011-04-19 |
US20080249099A1 (en) | 2008-10-09 |
NO337252B1 (no) | 2016-02-22 |
SG150534A1 (en) | 2009-03-30 |
CN1882549A (zh) | 2006-12-20 |
HK1100774A1 (en) | 2007-09-28 |
EP1709011A1 (en) | 2006-10-11 |
EP1709011B1 (en) | 2015-07-29 |
US20110230492A1 (en) | 2011-09-22 |
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