NO2006018I1 - Entekavir:(2-amino-1,9-dihydro-9Ä(1S,3R,4S)-4hydroksy-3-(hydroksymetyl)-2-metylencyklopentylÜ-6H-purin-6-on og hydrater derav, saerlig monohydrat - Google Patents

Entekavir:(2-amino-1,9-dihydro-9Ä(1S,3R,4S)-4hydroksy-3-(hydroksymetyl)-2-metylencyklopentylÜ-6H-purin-6-on og hydrater derav, saerlig monohydrat

Info

Publication number: NO2006018I1
Authority: NO; Norway
Prior art keywords: methylenecyclopentylü; entekavir; 4hydroxy; purin; hydrates
Prior art date: 1990-10-18

Application number

NO2006018C

Other languages

English (en)

Other versions

NO2006018I2 (no

Original Assignee

E R Squibb & Sons Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-18

Filing date

2006-12-05

Publication date

2006-12-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24400159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2006018(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-12-05 Application filed by E R Squibb & Sons Llc filed Critical E R Squibb & Sons Llc

2006-12-27 Publication of NO2006018I1 publication Critical patent/NO2006018I1/no

2008-10-20 Publication of NO2006018I2 publication Critical patent/NO2006018I2/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Tires In General (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)

NO2006018C 1990-10-18 2006-12-05 Entekavir NO2006018I2 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US59956890A	1990-10-18	1990-10-18

Publications (2)

Publication Number	Publication Date
NO2006018I1 true NO2006018I1 (no)	2006-12-27
NO2006018I2 NO2006018I2 (no)	2008-10-20

Family

ID=24400159

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO914089A NO179906C (no)	1990-10-18	1991-10-17	Fremgangsmåte for fremstilling av hydroksymetyl(metylencyklopentyl) puriner og -pyrimidiner
NO2006018C NO2006018I2 (no)	1990-10-18	2006-12-05	Entekavir

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO914089A NO179906C (no)	1990-10-18	1991-10-17	Fremgangsmåte for fremstilling av hydroksymetyl(metylencyklopentyl) puriner og -pyrimidiner

Country Status (28)

Country	Link
US (1)	US5206244A (no)
EP (1)	EP0481754B1 (no)
JP (1)	JP2994117B2 (no)
KR (1)	KR0160523B1 (no)
CN (1)	CN1030916C (no)
AT (1)	ATE157095T1 (no)
AU (1)	AU634423B2 (no)
BR (1)	BR1100846A (no)
CA (1)	CA2053339C (no)
CY (2)	CY2063B1 (no)
DE (3)	DE122006000069I1 (no)
DK (1)	DK0481754T3 (no)
ES (1)	ES2104673T3 (no)
FI (1)	FI109905B (no)
GR (1)	GR3025395T3 (no)
HK (1)	HK1001343A1 (no)
HU (1)	HU213207B (no)
IE (1)	IE913451A1 (no)
IL (1)	IL99755A (no)
LU (1)	LU91275I2 (no)
NL (1)	NL300241I1 (no)
NO (2)	NO179906C (no)
NZ (1)	NZ240053A (no)
PL (1)	PL169403B1 (no)
PT (1)	PT99281B (no)
RU (1)	RU2037496C1 (no)
SG (1)	SG70958A1 (no)
ZA (1)	ZA917894B (no)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0630897A3 (en)	1993-06-25	1995-03-01	Bristol Myers Squibb Co	3-hydroxy-4-hydroxymethyl-2-methylene-cyclopentyl purines and pyrimidines.
WO1996001834A1 (fr) *	1994-07-12	1996-01-25	Yamasa Corporation	2'-desoxy-2'-(methylidene substitue ou non substitue)-4'-thionucleoside
AU4303996A (en) *	1994-12-19	1996-07-10	Novartis Ag	6'-substituted carbocyclic nucleosides
GB9520363D0 (en) *	1995-10-05	1995-12-06	Chiroscience Ltd	Compounds
WO1998009964A1 (en) *	1996-09-03	1998-03-12	Bristol-Myers Squibb Company	IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE
DE122007000062I1 (de) *	1998-08-10	2007-12-20	Idenix Cayman Ltd	Beta-L-2'-deoxynukleoside für die Behandlung von Hepatitis-B-Virus
US6444652B1 (en) *	1998-08-10	2002-09-03	Novirio Pharmaceuticals Limited	β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
US6432966B2 (en)	1999-10-29	2002-08-13	Smithkline Beecham Corporation	Antiviral combinations
CN1813753B (zh) *	2000-02-29	2010-04-07	布里斯托尔-迈尔斯斯奎布公司	低剂量艾替开韦制剂及其应用
EA006181B1 (ru) *	2000-02-29	2005-10-27	Бристоль-Мейерз Сквибб Компани	Фармацевтический препарат на основе энтекавира и способ его получения
WO2001067772A2 (en) *	2000-03-09	2001-09-13	Videoshare, Inc.	Sharing a streaming video
MY131488A (en) *	2002-04-08	2007-08-30	Bristol Myers Squibb Co	Low dose liquid entecavir formulations and use
US7153691B2 (en) *	2002-11-13	2006-12-26	G6 Science Corp.	Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents
BR122019020833B8 (pt) *	2002-12-11	2021-07-27	Bristol Myers Squibb Holdings Ireland	agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi-3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona
TW200540175A (en) *	2004-06-04	2005-12-16	Bristol Myers Squibb Co	Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
US7511139B2 (en) *	2004-06-04	2009-03-31	Bristol-Myers Squibb Company	Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
CN100379736C (zh) *	2005-05-13	2008-04-09	上海仲夏化学有限公司	恩替卡韦的制备方法
CN1699366A (zh) *	2005-06-03	2005-11-23	北京市典范科技有限责任公司	嘌呤衍生物
CN1907987B (zh) *	2005-08-03	2010-05-05	江苏正大天晴药业股份有限公司	恩地卡韦酸加成盐及其制备方法和用途
US20070060599A1 (en) *	2005-09-09	2007-03-15	Dimarco John D	Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
CN101016299B (zh) *	2006-02-09	2010-05-12	北京典范科技有限责任公司	制备嘌呤衍生物的新方法
CN101130542B (zh) *	2006-08-24	2010-08-04	江苏正大天晴药业股份有限公司	抗病毒核苷类似物的合成方法
CN101210015B (zh) *	2006-12-26	2010-09-22	上海国创医药有限公司	一种乙肝治疗药物恩替卡韦的制备方法
CN101245068A (zh) *	2007-02-14	2008-08-20	浙江医药股份有限公司新昌制药厂	结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
CN101074217B (zh) *	2007-04-04	2010-11-24	北京精华耀邦医药科技有限公司	通过制备色谱分离得到高纯度恩替卡韦关键中间体的方法
USRE45004E1 (en)	2007-06-18	2014-07-08	Sunshine Lake Pharma Co., Ltd.	Bromo-phenyl substituted thiazolyl dihydropyrimidines
US20090076038A1 (en) *	2007-09-14	2009-03-19	Protia, Llc	Deuterium-enriched entecavir
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
TW201010692A (en)	2008-06-19	2010-03-16	Public Univ Corp Nagoya City Univ	Pharmaceutical composition for treatment or prevention of hbv infection
EP2376515A1 (en)	2008-12-23	2011-10-19	Pharmasset, Inc.	Synthesis of purine nucleosides
KR20110098849A (ko) *	2008-12-23	2011-09-01	파마셋 인코포레이티드	뉴클레오시드 유사체
ES2623016T3 (es) *	2008-12-23	2017-07-10	Gilead Pharmasset Llc	Fosforamidatos de nucleósido de 2-amino purina 6-O-sustituida
KR101150254B1 (ko) *	2008-12-26	2012-06-12	한미사이언스 주식회사	신규 중간체 및 이를 활용한 엔테카비르 제조방법
CN101531660B (zh) *	2009-04-14	2012-07-04	安徽贝克联合制药有限公司	一种恩替卡韦一水合物的工业化生产工艺
WO2011046303A2 (en) *	2009-10-12	2011-04-21	Hanmi Holdings Co., Ltd.	Novel method for preparing entecavir and intermediate used therein
US9700560B2 (en) *	2009-11-16	2017-07-11	University Of Georgia Research Foundation, Inc.	2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
CN101759698B (zh) *	2009-12-15	2012-01-18	上海医药集团股份有限公司	一种恩替卡韦的制备方法
US8481728B2 (en) *	2010-02-16	2013-07-09	Scinopharm Taiwan, Ltd.	Process for preparing entecavir and its intermediates
UA122959C2 (uk)	2010-03-31	2021-01-27	Гайлід Фармассет Елелсі	Нуклеозидфосфорамідати
CA2705953C (en)	2010-05-31	2018-05-01	Alphora Research Inc.	Carbanucleoside synthesis and intermediate compounds useful therein
EP2474548A1 (en) *	2010-12-23	2012-07-11	Esteve Química, S.A.	Preparation process of an antiviral drug and intermediates thereof
EP2508172A1 (en)	2011-04-06	2012-10-10	Zentiva, a.s.	Stable and uniform formulations of entecavir and preparation method thereof
CN102491960A (zh) *	2011-11-16	2012-06-13	福建广生堂药业股份有限公司	一种合成恩替卡韦的中间体及其制备方法和应用
EP2597096A1 (en)	2011-11-24	2013-05-29	Esteve Química, S.A.	Process for preparing entecavir and intermediates thereof
CN103304375B (zh) *	2012-03-12	2017-04-12	浙江奥翔药业股份有限公司	恩替卡韦的合成中间体及其制备方法
JP2015520144A (ja)	2012-05-11	2015-07-16	アクロン・モレキュールズ・アクチェンゲゼルシャフトＡｋｒｏｎＭｏｌｅｃｕｌｅｓＡｇ	疼痛の治療のための化合物の使用
US9227990B2 (en)	2012-10-29	2016-01-05	Cipla Limited	Antiviral phosphonate analogues and process for preparation thereof
WO2015014737A1 (en)	2013-07-29	2015-02-05	Sanovel Ilac Sanayi Ve Ticaret A.S.	Multilayer tablet formulations comprising tenofovir and entecavir
WO2015051900A1 (en)	2013-10-08	2015-04-16	Pharmathen S.A.	Process for the preparation of entecavir through novel intermediates
KR101640504B1 (ko) *	2015-04-15	2016-07-18	동방에프티엘(주)	엔테카비르 일수화물의 제조방법
KR101640503B1 (ko) *	2015-04-15	2016-07-18	동방에프티엘(주)	엔테카비르 일수화물의 개선된 제조방법
EP3543238B1 (en) *	2016-11-16	2021-05-19	National Center for Global Health and Medicine	Nucleoside derivatives having anti-viral activity
CN108203435B (zh) *	2016-12-16	2020-09-04	正大天晴药业集团股份有限公司	一种利用Boc保护基的恩替卡韦的制备方法
CN106749251A (zh) *	2017-01-17	2017-05-31	博瑞生物医药泰兴市有限公司	一种恩替卡韦中间体的合成与提纯方法
KR102197257B1 (ko) *	2017-10-19	2020-12-31	단국대학교 천안캠퍼스 산학협력단	엔테카비어 지방산 에스테르 유도체 수성현탁액의 안정화 조성물
CN109956975B (zh) *	2017-12-22	2020-11-06	浙江柏拉阿图医药科技有限公司	肝递送恩替卡韦前体药物核苷环磷酸酯化合物及应用
US20220033406A1 (en) *	2018-12-12	2022-02-03	Janssen Biopharma, Inc.	Cyclopentyl nucleoside analogs as anti-virals
CN113024574B (zh) *	2019-12-25	2024-03-29	南通诺泰生物医药技术有限公司	一种氧杂二环己烷类化合物的制备方法
CN111732589B (zh) *	2020-06-08	2021-07-30	王乔	一种改进的恩替卡韦中间体合成工艺以及改进的恩替卡韦合成工艺
CN112625041A (zh) *	2020-12-25	2021-04-09	常州博海威医药科技股份有限公司	恩替卡韦的新制备方法以及中间体
CN115433188B (zh) *	2022-09-29	2024-07-12	苏州东瑞制药有限公司	一种恩替卡韦的制备方法
CN115819422A (zh) *	2022-12-13	2023-03-21	淄博矿业集团有限责任公司	恩替卡韦中间体制备新工艺方法及分析方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN164556B (no) *	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US5063233A (en) *	1986-11-14	1991-11-05	Ciba-Geigy Corporation	N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
DE3854110T2 (de) *	1987-03-19	1995-11-30	Yamasa Shoyu Kk	2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.
US4997925A (en) *	1987-08-26	1991-03-05	Merrell Dow Pharmaceuticals Inc.	5'-deoxy-5',5'-dihalo adenosines and purine analogues
NZ225906A (en) *	1987-08-26	1990-10-26	Merrell Dow Pharma	Aristeromycin/adenosine derivatives and pharmaceutical compositions
GB8815265D0 (en) *	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
EP0566162B1 (en) *	1988-08-25	1997-06-11	Yoshitomi Pharmaceutical Industries, Ltd.	2'-Methylidenepyrimidine Nucleoside Compounds, their use and method for production thereof
HU204843B (en) *	1988-09-27	1992-02-28	Merrell Dow Pharma	Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
GB8916478D0 (en) *	1989-07-19	1989-09-06	Glaxo Group Ltd	Chemical process
US5064961A (en) *	1989-12-18	1991-11-12	E. R. Squibb & Sons, Inc.	Process for preparing an optically active cyclobutane nucleoside
US5057630A (en) *	1990-04-06	1991-10-15	Glaxo Inc.	Synthesis of cyclopentene derivatives

1991
- 1991-09-20 US US07/763,033 patent/US5206244A/en not_active Expired - Lifetime
- 1991-10-01 NZ NZ240053A patent/NZ240053A/xx not_active IP Right Cessation
- 1991-10-01 IE IE345191A patent/IE913451A1/en active Protection Beyond IP Right Term
- 1991-10-02 ZA ZA917894A patent/ZA917894B/xx unknown
- 1991-10-04 AU AU85598/91A patent/AU634423B2/en not_active Expired
- 1991-10-11 CA CA002053339A patent/CA2053339C/en not_active Expired - Lifetime
- 1991-10-15 IL IL9975591A patent/IL99755A/en not_active IP Right Cessation
- 1991-10-16 EP EP91309525A patent/EP0481754B1/en not_active Expired - Lifetime
- 1991-10-16 DE DE1991627336 patent/DE122006000069I1/de active Pending
- 1991-10-16 SG SG1996002080A patent/SG70958A1/en unknown
- 1991-10-16 DK DK91309525.3T patent/DK0481754T3/da active
- 1991-10-16 AT AT91309525T patent/ATE157095T1/de active
- 1991-10-16 DE DE69127336T patent/DE69127336T2/de not_active Expired - Lifetime
- 1991-10-16 ES ES91309525T patent/ES2104673T3/es not_active Expired - Lifetime
- 1991-10-17 KR KR1019910018259A patent/KR0160523B1/ko not_active IP Right Cessation
- 1991-10-17 HU HU913283A patent/HU213207B/hu active Protection Beyond IP Right Term
- 1991-10-17 RU SU915001946A patent/RU2037496C1/ru active Protection Beyond IP Right Term
- 1991-10-17 NO NO914089A patent/NO179906C/no not_active IP Right Cessation
- 1991-10-18 PT PT99281A patent/PT99281B/pt not_active IP Right Cessation
- 1991-10-18 PL PL91292101A patent/PL169403B1/pl unknown
- 1991-10-18 CN CN91110831A patent/CN1030916C/zh not_active Expired - Lifetime
- 1991-10-18 JP JP3271121A patent/JP2994117B2/ja not_active Expired - Lifetime
- 1991-10-18 FI FI914928A patent/FI109905B/fi active Protection Beyond IP Right Term
1997
- 1997-05-12 BR BR1100846-6A patent/BR1100846A/pt active IP Right Grant
- 1997-11-17 GR GR970403039T patent/GR3025395T3/el unknown
1998
- 1998-01-19 HK HK98100422A patent/HK1001343A1/xx not_active IP Right Cessation
- 1998-06-12 CY CY9802063A patent/CY2063B1/xx unknown
2006
- 2006-08-30 LU LU91275C patent/LU91275I2/fr unknown
- 2006-09-21 NL NL300241C patent/NL300241I1/nl unknown
- 2006-12-05 NO NO2006018C patent/NO2006018I2/no unknown
- 2006-12-22 DE DE200612000069 patent/DE122006000069I2/de active Active
2014
- 2014-09-29 CY CY2006008C patent/CY2006008I2/el unknown

Also Published As

Publication number	Publication date
JP2994117B2 (ja)	1999-12-27
KR920008043A (ko)	1992-05-27
EP0481754A3 (en)	1992-09-16
CA2053339A1 (en)	1992-04-19
NO2006018I2 (no)	2008-10-20
KR0160523B1 (ko)	1998-12-01
LU91275I2 (fr)	2007-06-16
NL300241I1 (nl)	2006-12-01
DE122006000069I1 (de)	2007-05-24
NO914089D0 (no)	1991-10-17
DE69127336D1 (de)	1997-09-25
CY2063B1 (en)	1998-06-12
HK1001343A1 (en)	1998-06-12
NZ240053A (en)	1993-05-26
DK0481754T3 (da)	1997-09-15
ZA917894B (en)	1993-03-31
DE69127336T2 (de)	1998-01-02
EP0481754B1 (en)	1997-08-20
IL99755A (en)	1996-08-04
HUT59109A (en)	1992-04-28
DE122006000069I2 (de)	2012-04-19
GR3025395T3 (en)	1998-02-27
CN1061972A (zh)	1992-06-17
CY2006008I2 (el)	2016-10-05
ATE157095T1 (de)	1997-09-15
PL292101A1 (en)	1992-08-10
FI109905B (fi)	2002-10-31
FI914928A0 (fi)	1991-10-18
PL169403B1 (pl)	1996-07-31
NO179906C (no)	1997-01-08
IL99755A0 (en)	1992-08-18
SG70958A1 (en)	2000-03-21
NO914089L (no)	1992-04-21
RU2037496C1 (ru)	1995-06-19
EP0481754A2 (en)	1992-04-22
CY2006008I1 (el)	2009-11-04
PT99281B (pt)	1999-04-30
HU213207B (en)	1997-03-28
NO179906B (no)	1996-09-30
ES2104673T3 (es)	1997-10-16
CA2053339C (en)	2001-05-29
FI914928A (fi)	1992-04-19
PT99281A (pt)	1992-08-31
BR1100846A (pt)	2000-04-18
AU8559891A (en)	1992-04-30
HU913283D0 (en)	1992-01-28
JPH04282373A (ja)	1992-10-07
AU634423B2 (en)	1993-02-18
CN1030916C (zh)	1996-02-07
IE913451A1 (en)	1992-04-22
US5206244A (en)	1993-04-27

Publication	Publication Date	Title
NO2006018I1 (no)	2006-12-27	Entekavir:(2-amino-1,9-dihydro-9Ä(1S,3R,4S)-4hydroksy-3-(hydroksymetyl)-2-metylencyklopentylÜ-6H-purin-6-on og hydrater derav, saerlig monohydrat
ES2056096T3 (es)	1994-10-01	Purinil-ciclobutanos.
DK0386675T3 (da)	1996-06-24	Xanthinderivater
DK0566175T3 (da)	1998-01-26	3,4-diaryl-(5H)-furan-2-on-baserede forbindelser med fungicid aktivitet
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
DK0417746T3 (da)	1994-12-12	N-Azabicyclo(3.3.0)octanamider af aromatiske syrer
MX9205408A (es)	1993-03-01	Metodo para tratar hipertension.
ATE159253T1 (de)	1997-11-15	2-thiazolylpyrroleakrylate mit fungizider wirkung

Legal Events

Date	Code	Title	Description
2014-11-10	CHAD	Change of the owner's name or address (par. 44 patent law; par. patentforskriften)	Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH