NO20024741D0 - 8-quinolinxantin og 8-isoquinolinxantinderivater som PDE5- inhibitorer - Google Patents

8-quinolinxantin og 8-isoquinolinxantinderivater som PDE5- inhibitorer

Info

Publication number: NO20024741D0
Authority: NO; Norway
Prior art keywords: xanthine; isoquinoline; quinoline; pde5 inhibitors; derivatives
Prior art date: 2000-04-07

Application number

NO20024741A

Other languages

English (en)

Norwegian (no)

Other versions

NO20024741L (no

Inventor

Gurdip Bhalay

Stephen Paul Collingwood

Robin Alec Fairhurst

Sylvie Felicite Gomez

Reto Naef

David Andrew Sandham

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-07

Filing date

2002-10-02

Publication date

2002-10-02

2002-10-02 Application filed by Novartis Ag filed Critical Novartis Ag

2002-10-02 Publication of NO20024741L publication Critical patent/NO20024741L/no

2002-10-02 Publication of NO20024741D0 publication Critical patent/NO20024741D0/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P17/06—Antipsoriatics
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- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/16—Otologicals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

NO20024741A 2000-04-07 2002-10-02 8-quinolinxantin og 8-isoquinolinxantinderivater som PDE5- inhibitorer NO20024741D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0008694.2A GB0008694D0 (en)	2000-04-07	2000-04-07	Organic compounds
PCT/EP2001/003909 WO2001077110A1 (en)	2000-04-07	2001-04-05	8-quinolinxanthine and 8-isoquinolinxanthine derivatives as pde 5 inhibitors

Publications (2)

Publication Number	Publication Date
NO20024741L NO20024741L (no)	2002-10-02
NO20024741D0 true NO20024741D0 (no)	2002-10-02

Family

ID=9889516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20024741A NO20024741D0 (no)	2000-04-07	2002-10-02	8-quinolinxantin og 8-isoquinolinxantinderivater som PDE5- inhibitorer

Country Status (29)

Country	Link
US (1)	US20030171384A1 (es)
EP (1)	EP1268480B1 (es)
JP (1)	JP3869725B2 (es)
KR (1)	KR100526094B1 (es)
CN (1)	CN1176922C (es)
AR (1)	AR028531A1 (es)
AT (1)	ATE253576T1 (es)
AU (2)	AU2001273921B2 (es)
BR (1)	BR0109855A (es)
CA (1)	CA2403514C (es)
CZ (1)	CZ20023305A3 (es)
DE (1)	DE60101158T2 (es)
DK (1)	DK1268480T3 (es)
ES (1)	ES2210169T3 (es)
GB (1)	GB0008694D0 (es)
HU (1)	HUP0300565A3 (es)
IL (1)	IL152078A0 (es)
MX (1)	MXPA02009903A (es)
MY (1)	MY119238A (es)
NO (1)	NO20024741D0 (es)
NZ (1)	NZ521361A (es)
PE (1)	PE20020228A1 (es)
PL (1)	PL212407B1 (es)
PT (1)	PT1268480E (es)
RU (1)	RU2269529C2 (es)
SK (1)	SK14282002A3 (es)
TR (1)	TR200400185T4 (es)
WO (1)	WO2001077110A1 (es)
ZA (1)	ZA200207956B (es)

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DE10135815A1 (de) *	2001-07-23	2003-02-06	Bayer Ag	Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
US7019010B2 (en) *	2001-09-27	2006-03-28	Novertis Ag	Combinations
ES2324215T3 (es)	2002-06-12	2009-08-03	F. Hoffmann-La Roche Ag	Derivados de xantina sustituidos con amida con actividad moduladora de la gluconeogenesis.
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
EA016166B1 (ru) *	2002-08-21	2012-02-28	Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг	8-[3-аминопиперидин-1-ил]ксантины, способ их получения и их применение в качестве лекарственных средств
AU2004213124A1 (en) *	2003-02-19	2004-09-02	F. Hoffmann-La Roche Ag	Sulfonamide substituted xanthine derivatives for use as PEPCK inhibitors
US7148229B2 (en)	2003-02-19	2006-12-12	Hoffman-La Roche Inc.	Sulfonamide substituted xanthine derivatives
JP4859666B2 (ja) *	2003-06-06	2012-01-25	エンダセア，インコーポレイテッド	Ａ１アデノシンレセプターアンタゴニスト
KR100658080B1 (ko) *	2003-08-26	2006-12-15	비오이 하이디스 테크놀로지 주식회사	백라이트 조립용 지그
TW200605893A (en) *	2004-02-12	2006-02-16	Novartis Ag	Use of organic compounds
US7501426B2 (en)	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
JP5220407B2 (ja) *	2004-05-08	2013-06-26	ノバルティス・インターナショナル・ファーマシューティカル・リミテッド	１−アリール−４−置換イソキノリン類
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005001989A1 (de) *	2005-01-15	2006-07-20	Bayer Healthcare Ag	Intravenöse Formulierungen von PDE-Inhibitoren
US7601723B2 (en) *	2005-02-25	2009-10-13	Pgx Health, Llc	Pyridyl substituted xanthines
US20070004745A1 (en) *	2005-03-25	2007-01-04	Schering-Plough Corporation	Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
DE102005035891A1 (de)	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US8067433B2 (en)	2005-11-09	2011-11-29	Zalicus Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
PE20110235A1 (es)	2006-05-04	2011-04-14	Boehringer Ingelheim Int	Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	DPP IV inhibitor formulations
CN101437823B (zh)	2006-05-04	2014-12-10	勃林格殷格翰国际有限公司	多晶型
JP2010532319A (ja) *	2007-06-13	2010-10-07	バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト	聴覚障害の処置用のｐｄｅ阻害剤
AR071175A1 (es)	2008-04-03	2010-06-02	Boehringer Ingelheim Int	Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt)	2008-08-06	2020-12-15	Boehringer Ingelheim International Gmbh	Inibidor de dpp-4 e seu uso
EP2344195A2 (en)	2008-09-10	2011-07-20	Boehringer Ingelheim International GmbH	Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ592924A (en)	2008-12-23	2014-05-30	Boehringer Ingelheim Int	Salt forms of a xanthine derivative
AR074990A1 (es)	2009-01-07	2011-03-02	Boehringer Ingelheim Int	Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EP2410855B1 (en) *	2009-03-26	2016-06-01	Mapi Pharma Limited	Process for the preparation of alogliptin
BR112012012641A2 (pt)	2009-11-27	2020-08-11	Boehringer Ingelheim International Gmbh	TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA
MX341025B (es)	2010-05-05	2016-08-04	Boehringer Ingelheim Int Gmbh *	Terapia de combinacion.
ES2802243T3 (es)	2010-06-24	2021-01-18	Boehringer Ingelheim Int	Terapia para la diabetes
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CN103476757A (zh) *	2011-02-18	2013-12-25	阿勒根公司	作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物
EP3517539B1 (en)	2011-07-15	2022-12-14	Boehringer Ingelheim International GmbH	Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
WO2013171167A1 (en)	2012-05-14	2013-11-21	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014071044A1 (en) *	2012-11-01	2014-05-08	Allergan, Inc.	Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
WO2015128453A1 (en)	2014-02-28	2015-09-03	Boehringer Ingelheim International Gmbh	Medical use of a dpp-4 inhibitor
AU2017276758A1 (en)	2016-06-10	2018-11-08	Boehringer Ingelheim International Gmbh	Combinations of Linagliptin and metformin

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FR2558162B1 (fr) *	1984-01-17	1986-04-25	Adir	Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
GB9301192D0 (en) *	1993-06-09	1993-06-09	Trott Francis W	Flower shaped mechanised table
WO1999062905A1 (en) *	1998-06-03	1999-12-09	Almirall Prodesfarma, S.A.	8-phenylxanthine derivatives and their use as phosphodiesterase inhibitors
GB9828340D0 (en) *	1998-12-22	1999-02-17	Novartis Ag	Organic compounds

2000
- 2000-04-07 GB GBGB0008694.2A patent/GB0008694D0/en not_active Ceased
2001
- 2001-04-05 EP EP01940294A patent/EP1268480B1/en not_active Expired - Lifetime
- 2001-04-05 DK DK01940294T patent/DK1268480T3/da active
- 2001-04-05 CN CNB018074898A patent/CN1176922C/zh not_active Expired - Fee Related
- 2001-04-05 MY MYPI20011632A patent/MY119238A/en unknown
- 2001-04-05 PL PL358205A patent/PL212407B1/pl unknown
- 2001-04-05 HU HU0300565A patent/HUP0300565A3/hu unknown
- 2001-04-05 JP JP2001575583A patent/JP3869725B2/ja not_active Expired - Fee Related
- 2001-04-05 CZ CZ20023305A patent/CZ20023305A3/cs unknown
- 2001-04-05 TR TR2004/00185T patent/TR200400185T4/xx unknown
- 2001-04-05 NZ NZ521361A patent/NZ521361A/en unknown
- 2001-04-05 WO PCT/EP2001/003909 patent/WO2001077110A1/en active IP Right Grant
- 2001-04-05 IL IL15207801A patent/IL152078A0/xx unknown
- 2001-04-05 RU RU2002129557/04A patent/RU2269529C2/ru not_active IP Right Cessation
- 2001-04-05 AU AU2001273921A patent/AU2001273921B2/en not_active Ceased
- 2001-04-05 KR KR10-2002-7012627A patent/KR100526094B1/ko not_active IP Right Cessation
- 2001-04-05 CA CA002403514A patent/CA2403514C/en not_active Expired - Fee Related
- 2001-04-05 AR ARP010101623A patent/AR028531A1/es not_active Application Discontinuation
- 2001-04-05 SK SK1428-2002A patent/SK14282002A3/sk unknown
- 2001-04-05 BR BR0109855-1A patent/BR0109855A/pt not_active IP Right Cessation
- 2001-04-05 AT AT01940294T patent/ATE253576T1/de active
- 2001-04-05 US US10/240,481 patent/US20030171384A1/en not_active Abandoned
- 2001-04-05 MX MXPA02009903A patent/MXPA02009903A/es active IP Right Grant
- 2001-04-05 DE DE60101158T patent/DE60101158T2/de not_active Expired - Lifetime
- 2001-04-05 AU AU7392101A patent/AU7392101A/xx active Pending
- 2001-04-05 PE PE2001000317A patent/PE20020228A1/es not_active Application Discontinuation
- 2001-04-05 PT PT01940294T patent/PT1268480E/pt unknown
- 2001-04-05 ES ES01940294T patent/ES2210169T3/es not_active Expired - Lifetime
2002
- 2002-10-02 NO NO20024741A patent/NO20024741D0/no not_active Application Discontinuation
- 2002-10-03 ZA ZA200207956A patent/ZA200207956B/en unknown

Also Published As

Publication number	Publication date
PL358205A1 (en)	2004-08-09
NO20024741L (no)	2002-10-02
CA2403514A1 (en)	2001-10-18
AU2001273921B2 (en)	2005-05-05
WO2001077110A1 (en)	2001-10-18
EP1268480A1 (en)	2003-01-02
TR200400185T4 (tr)	2004-03-22
AU7392101A (en)	2001-10-23
KR100526094B1 (ko)	2005-11-08
KR20020081590A (ko)	2002-10-28
CA2403514C (en)	2010-01-12
HUP0300565A2 (hu)	2003-07-28
CN1420887A (zh)	2003-05-28
CN1176922C (zh)	2004-11-24
US20030171384A1 (en)	2003-09-11
PL212407B1 (pl)	2012-09-28
HUP0300565A3 (en)	2004-10-28
NZ521361A (en)	2004-05-28
GB0008694D0 (en)	2000-05-31
JP3869725B2 (ja)	2007-01-17
PE20020228A1 (es)	2002-03-28
AR028531A1 (es)	2003-05-14
RU2269529C2 (ru)	2006-02-10
MXPA02009903A (es)	2003-03-27
BR0109855A (pt)	2003-06-03
ES2210169T3 (es)	2004-07-01
CZ20023305A3 (cs)	2003-01-15
PT1268480E (pt)	2004-03-31
ATE253576T1 (de)	2003-11-15
JP2003530398A (ja)	2003-10-14
SK14282002A3 (sk)	2003-04-01
DE60101158T2 (de)	2004-08-26
DK1268480T3 (da)	2004-03-15
IL152078A0 (en)	2003-05-29
ZA200207956B (en)	2003-07-16
DE60101158D1 (en)	2003-12-11
EP1268480B1 (en)	2003-11-05
RU2002129557A (ru)	2004-03-27
MY119238A (en)	2005-04-30

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