NO20005161D0 - N,N-disubstituerte amider som inhiberer bindingen av integriner til deres reseptorer - Google Patents

N,N-disubstituerte amider som inhiberer bindingen av integriner til deres reseptorer

Info

Publication number: NO20005161D0
Authority: NO; Norway
Prior art keywords: binding; receptors; inhibit; integrins; compounds
Prior art date: 1998-04-16

Application number

NO20005161A

Other languages

English (en)

Other versions

NO20005161L (no

Inventor

Jamal M Kassir

Ronald J Biediger

Vanessa O Grabbe

Shuqun Lin

Robert V Market

Bore G Raju

Ian L Scott

Timothy P Kogan

Original Assignee

Texas Biotechnology Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-16

Filing date

2000-10-13

Publication date

2000-10-13

2000-10-13 Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp

2000-10-13 Publication of NO20005161D0 publication Critical patent/NO20005161D0/no

2000-12-15 Publication of NO20005161L publication Critical patent/NO20005161L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Hematology (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Transplantation (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

NO20005161A 1998-04-16 2000-10-13 N,N-disubstituerte amider som inhiberer bindingen av integriner til deres reseptorer NO20005161L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8201998P	1998-04-16	1998-04-16
PCT/US1999/008302 WO1999052898A1 (en)	1998-04-16	1999-04-15	N,n-disubstituted amides that inhibit the binding of integrins to their receptors

Publications (2)

Publication Number	Publication Date
NO20005161D0 true NO20005161D0 (no)	2000-10-13
NO20005161L NO20005161L (no)	2000-12-15

Family

ID=22168519

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20005161A NO20005161L (no)	1998-04-16	2000-10-13	N,N-disubstituerte amider som inhiberer bindingen av integriner til deres reseptorer
NO20005162A NO20005162L (no)	1998-04-16	2000-10-13	Forbindelser som inhiberer bindingen av integriner til deres reseptorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20005162A NO20005162L (no)	1998-04-16	2000-10-13	Forbindelser som inhiberer bindingen av integriner til deres reseptorer

Country Status (20)

Country	Link
US (3)	US6096773A (no)
EP (2)	EP1071680B1 (no)
JP (2)	JP4949552B2 (no)
KR (2)	KR20010087125A (no)
CN (2)	CN1311676A (no)
AT (2)	ATE474573T1 (no)
AU (2)	AU3563799A (no)
BR (2)	BR9909625A (no)
CA (2)	CA2328234C (no)
DE (2)	DE69939165D1 (no)
ES (2)	ES2345471T3 (no)
HU (2)	HUP0103752A3 (no)
ID (1)	ID28658A (no)
IL (2)	IL138972A0 (no)
NO (2)	NO20005161L (no)
NZ (1)	NZ507534A (no)
PL (2)	PL343770A1 (no)
SK (2)	SK15602000A3 (no)
TR (2)	TR200100139T2 (no)
WO (2)	WO1999052898A1 (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6306909B1 (en)	1997-03-12	2001-10-23	Queen's University At Kingston	Anti-epileptogenic agents
US20060281681A1 (en)	1997-05-28	2006-12-14	Pilon Aprile L	Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease
GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
US6521626B1 (en)	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
ES2345471T3 (es)	1998-04-16	2010-09-23	Encysive Pharmaceuticals, Inc.	Compuestos que inhiben la union de integrinas a sus receptores.
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en) *	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
JP2002535304A (ja)	1999-01-22	2002-10-22	エランファーマシューティカルズ，インコーポレイテッド	Ｖａｌ−４により媒介される白血球接着を阻害する多環式化合物
PL350050A1 (en)	1999-01-22	2002-10-21	Elan Pharm Inc	Acyl derivatives which treat vla-4 related disorders
TW593284B (en)	1999-01-22	2004-06-21	Elan Pharm Inc	Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en)	1999-01-25	2002-08-20	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1161416B1 (en)	1999-03-01	2004-04-14	Elan Pharmaceuticals, Inc.	Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 - receptor antagonists
US6972296B2 (en) *	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6723711B2 (en) *	1999-05-07	2004-04-20	Texas Biotechnology Corporation	Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6420418B1 (en)	1999-08-16	2002-07-16	Merck & Co., Inc.	Heterocycle amides as cell adhesion inhibitors
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
AU2018301A (en)	1999-12-28	2001-07-24	Pfizer Products Inc.	Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
CA2399001C (en) *	2000-02-03	2010-07-20	Eisai Co., Ltd.	Integrin expression inhibitor
CA2405690A1 (en) *	2000-04-14	2002-10-09	Kureha Chemical Industry Company, Limited	Nitrogen-containing compounds and antiviral drugs containing the same
ES2295150T3 (es)	2000-04-17	2008-04-16	Ucb Pharma, S.A.	Derivados de enamina como moleculas de adhesion celular.
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
WO2002010136A1 (en)	2000-08-02	2002-02-07	Celltech R & D Limited	3-substituted isoquinolin-1-yl derivatives
DE10063173A1 (de)	2000-12-18	2002-06-20	Merck Patent Gmbh	Harnstoff- und Urethanderivate
JPWO2002094261A1 (ja) *	2001-05-24	2004-09-02	呉羽化学工業株式会社	含窒素化合物からなるｃｘｃｒ４拮抗作用を有する薬剤
WO2002096424A1 (en) *	2001-05-25	2002-12-05	Queen's University At Kingston	Hetereocyclic beta-aminoacids and their use as anti-epileptogenic agents
JPWO2003029218A1 (ja) *	2001-09-28	2005-01-13	呉羽化学工業株式会社	新規含窒素化合物及びその用途
SI21096B (sl) *	2001-10-09	2012-05-31	Encysive Pharmaceuticals Inc	Derivati karboksilne kisline ki inhibirajo vezavo integrinov na njihove receptorje
TWI281470B (en)	2002-05-24	2007-05-21	Elan Pharm Inc	Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en)	2002-05-24	2003-12-16	Elan Pharm Inc	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
WO2004014844A2 (en) *	2002-08-09	2004-02-19	Transtech Pharma, Inc.	Aryl and heteroaryl compounds and methods to modulate coagulation
FR2843964B1 (fr) *	2002-08-29	2004-10-01	Sanofi Synthelabo	Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
JP3714948B2 (ja) *	2002-09-11	2005-11-09	呉羽化学工業株式会社	アミン化合物及びその用途
US7208601B2 (en) *	2003-08-08	2007-04-24	Mjalli Adnan M M	Aryl and heteroaryl compounds, compositions, and methods of use
CA2531796A1 (en) *	2003-08-08	2005-02-17	Transtech Pharma, Inc.	Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014534A1 (en) *	2003-08-08	2005-02-17	Transtech Pharma, Inc.	Aryl and heteroaryl compounds, compositions, and methods of use
US20050171167A1 (en) *	2003-11-04	2005-08-04	Haby Thomas A.	Process and formulation containing epothilones and analogs thereof
US8227434B1 (en)	2003-11-04	2012-07-24	H. Lee Moffitt Cancer Center & Research Institute, Inc.	Materials and methods for treating oncological disorders
FR2865205B1 (fr) *	2004-01-16	2006-02-24	Sanofi Synthelabo	Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
JP3977411B2 (ja) *	2004-03-10	2007-09-19	株式会社クレハ	アミン系塩基性化合物とその用途
US7615556B2 (en) *	2006-01-27	2009-11-10	Bristol-Myers Squibb Company	Piperazinyl derivatives as modulators of chemokine receptor activity
US7601844B2 (en) *	2006-01-27	2009-10-13	Bristol-Myers Squibb Company	Piperidinyl derivatives as modulators of chemokine receptor activity
JP5773437B2 (ja)	2008-05-13	2015-09-02	セラブロン，インコーポレイテッド	鼻性鼻炎の治療に使用するための組換えヒトｃｃ１０およびその組成物
TWI433838B (zh)	2008-06-25	2014-04-11	必治妥美雅史谷比公司	作為趨化因子受體活性調節劑之六氫吡啶衍生物
US9168285B2 (en)	2009-10-15	2015-10-27	Therabron Therapeutics, Inc.	Recombinant human CC10 protein for treatment of influenza and ebola
BR112012008463A2 (pt)	2009-10-15	2019-09-24	Clarassance Inc	proteína recombinante humana cc10 para tratamento de gripe
US8642622B2 (en)	2010-06-16	2014-02-04	Bristol-Myers Squibb Company	Piperidinyl compound as a modulator of chemokine receptor activity
AU2011328904A1 (en)	2010-11-16	2013-06-06	Texas Heart Institute	Agonists that enhance binding of integrin-expressing cells to integrin receptors
EP3116910A1 (en)	2014-03-13	2017-01-18	Prothena Biosciences Limited	Combination treatment for multiple sclerosis
CA2954175C (en)	2014-07-01	2023-07-25	Upendra K. Marathi	Compositions and methods to improve adoptive cell therapies
US10875875B2 (en) *	2017-04-26	2020-12-29	Aviara Pharmaceuticals, Inc.	Propionic acid derivatives and methods of use thereof
US20210393811A1 (en) *	2018-10-05	2021-12-23	Texas Heart Institute	Imaging Agents and Methods of Use
AU2019373244B2 (en)	2018-10-30	2022-05-26	Gilead Sciences, Inc.	Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
US11224600B2 (en)	2018-10-30	2022-01-18	Gilead Sciences, Inc.	Compounds for inhibition of alpha 4 beta 7 integrin
US20220119383A1 (en)	2018-10-30	2022-04-21	Gilead Sciences, Inc.	Quinoline derivatives as alpha4beta7 integrin inhibitors
CA3115830C (en)	2018-10-30	2023-09-12	Gilead Sciences, Inc.	Compounds for inhibition of .alpha.4.beta.7 integrin
JP7491996B2 (ja)	2019-08-14	2024-05-28	ギリアードサイエンシーズ，インコーポレイテッド	α４β７インテグリンの阻害のための化合物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4372974A (en) *	1980-06-25	1983-02-08	New York University	Anticonvulsive compositions and method of treating convulsive disorders
US5378729A (en) *	1985-02-15	1995-01-03	Research Corporation Technologies, Inc.	Amino acid derivative anticonvulsant
US5654301A (en) *	1985-02-15	1997-08-05	Research Corporation Technologies, Inc.	Amino acid derivative anticonvulsant
ZW6189A1 (en) *	1988-05-09	1990-05-09	Smithkline Beckman Corp	Anti-aggregatory peptides
JPH0612525B2 (ja)	1989-10-12	1994-02-16	インターナショナル・ビシネス・マシーンズ・コーポレーション	コンピュータプログラムの最適化方法
NZ235563A (en) *	1989-10-13	1993-04-28	Merck & Co Inc	Fibrinogen receptor antagonist and pharmaceutical composition
NZ235564A (en)	1989-10-13	1993-10-26	Merck & Co Inc	Fibrinogen receptor antagonist and pharmaceutical compositions
US5192746A (en) *	1990-07-09	1993-03-09	Tanabe Seiyaku Co., Ltd.	Cyclic cell adhesion modulation compounds
JPH06192273A (ja) *	1992-10-26	1994-07-12	Lederle Japan Ltd	カルバペネム−３−カルボン酸エステル誘導体
AU681396B2 (en)	1993-03-31	1997-08-28	G.D. Searle & Co.	1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors
JPH06298797A (ja) *	1993-04-12	1994-10-25	Fuji Photo Film Co Ltd	ペプチド誘導体およびその用途
JP3190765B2 (ja) *	1993-05-13	2001-07-23	富士写真フイルム株式会社	ペプチド誘導体及びその用途
US5821231A (en)	1993-12-06	1998-10-13	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using same
WO1995015973A1 (en) *	1993-12-06	1995-06-15	Cytel Corporation	Cs-1 peptidomimetics, compositions and methods of using the same
US5936065A (en)	1993-12-06	1999-08-10	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using the same
US5770573A (en)	1993-12-06	1998-06-23	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using the same
US5510332A (en) *	1994-07-07	1996-04-23	Texas Biotechnology Corporation	Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
US5811391A (en) *	1994-08-25	1998-09-22	Cytel Corporation	Cyclic CS-1 peptidomimetics, compositions and methods of using same
JP2920741B2 (ja) *	1994-12-14	1999-07-19	参天製薬株式会社	新規１，３−ジアルキルウレア誘導体
US6306840B1 (en) *	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
CA2261848C (en) *	1996-07-25	2006-10-24	Biogen, Inc.	Cell adhesion inhibitors
AR014903A1 (es)	1997-07-31	2001-04-11	Athena Neurosciences Inc	Compuestos del tipo 4-amino-fenilalanina inhibidores de la adhesion de leucocitos intermediada por vla-4, compuesto que son droga de dichos compuestos,composiciones farmaceuticas, metodo para adherir vla-4 en una muestra biologica, metodo para tratar una condicion inflamatoria
SK5462000A3 (en) *	1997-10-31	2001-02-12	Aventis Pharma Ltd	Substituted anilides
GB9723789D0 (en)	1997-11-12	1998-01-07	Zeneca Ltd	Chemical compounds
HUP0100397A3 (en) *	1997-12-17	2002-10-28	Merck & Co Inc	Tetrahydro- or octahydrobenzonaphtyridin and quinolin derivatives, pharmaceutical compositions thereof and process for their preparation
ES2345471T3 (es)	1998-04-16	2010-09-23	Encysive Pharmaceuticals, Inc.	Compuestos que inhiben la union de integrinas a sus receptores.

1999
- 1999-04-15 ES ES99917544T patent/ES2345471T3/es not_active Expired - Lifetime
- 1999-04-15 AT AT99917544T patent/ATE474573T1/de not_active IP Right Cessation
- 1999-04-15 IL IL13897299A patent/IL138972A0/xx unknown
- 1999-04-15 IL IL13897399A patent/IL138973A0/xx unknown
- 1999-04-15 TR TR2001/00139T patent/TR200100139T2/xx unknown
- 1999-04-15 JP JP2000543456A patent/JP4949552B2/ja not_active Expired - Fee Related
- 1999-04-15 TR TR2001/00141T patent/TR200100141T2/xx unknown
- 1999-04-15 DE DE69939165T patent/DE69939165D1/de not_active Expired - Lifetime
- 1999-04-15 NZ NZ507534A patent/NZ507534A/en unknown
- 1999-04-15 SK SK1560-2000A patent/SK15602000A3/sk not_active Application Discontinuation
- 1999-04-15 US US09/292,459 patent/US6096773A/en not_active Expired - Lifetime
- 1999-04-15 ES ES99919856T patent/ES2308839T3/es not_active Expired - Lifetime
- 1999-04-15 CA CA002328234A patent/CA2328234C/en not_active Expired - Fee Related
- 1999-04-15 WO PCT/US1999/008302 patent/WO1999052898A1/en not_active Application Discontinuation
- 1999-04-15 SK SK1559-2000A patent/SK15592000A3/sk unknown
- 1999-04-15 ID IDW20002066A patent/ID28658A/id unknown
- 1999-04-15 KR KR1020007011406A patent/KR20010087125A/ko not_active Application Discontinuation
- 1999-04-15 KR KR1020007011423A patent/KR20010042704A/ko not_active Application Discontinuation
- 1999-04-15 CA CA2328990A patent/CA2328990C/en not_active Expired - Fee Related
- 1999-04-15 BR BR9909625-0A patent/BR9909625A/pt not_active IP Right Cessation
- 1999-04-15 EP EP99919856A patent/EP1071680B1/en not_active Expired - Lifetime
- 1999-04-15 PL PL99343770A patent/PL343770A1/xx not_active Application Discontinuation
- 1999-04-15 CN CN99808487A patent/CN1311676A/zh active Pending
- 1999-04-15 EP EP99917544A patent/EP1079825B1/en not_active Expired - Lifetime
- 1999-04-15 AU AU35637/99A patent/AU3563799A/en not_active Abandoned
- 1999-04-15 HU HU0103752A patent/HUP0103752A3/hu unknown
- 1999-04-15 AT AT99919856T patent/ATE402170T1/de not_active IP Right Cessation
- 1999-04-15 DE DE69942610T patent/DE69942610D1/de not_active Expired - Lifetime
- 1999-04-15 AU AU37483/99A patent/AU3748399A/en not_active Abandoned
- 1999-04-15 BR BR9909626-9A patent/BR9909626A/pt not_active IP Right Cessation
- 1999-04-15 CN CN99807342A patent/CN1305473A/zh active Pending
- 1999-04-15 JP JP2000543106A patent/JP4753403B2/ja not_active Expired - Fee Related
- 1999-04-15 HU HU0101419A patent/HUP0101419A3/hu unknown
- 1999-04-15 WO PCT/US1999/008305 patent/WO1999052493A2/en not_active Application Discontinuation
- 1999-04-15 PL PL99346220A patent/PL346220A1/xx unknown
- 1999-10-14 US US09/417,857 patent/US6194448B1/en not_active Expired - Lifetime
- 1999-10-14 US US09/417,886 patent/US6262084B1/en not_active Expired - Lifetime
2000
- 2000-10-13 NO NO20005161A patent/NO20005161L/no not_active Application Discontinuation
- 2000-10-13 NO NO20005162A patent/NO20005162L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ507534A (en)	2002-02-01
JP2002511397A (ja)	2002-04-16
ES2308839T3 (es)	2008-12-01
IL138973A0 (en)	2001-11-25
PL346220A1 (en)	2002-01-28
EP1071680A1 (en)	2001-01-31
ATE474573T1 (de)	2010-08-15
ID28658A (id)	2001-06-21
DE69939165D1 (de)	2008-09-04
KR20010087125A (ko)	2001-09-15
US6194448B1 (en)	2001-02-27
US6096773A (en)	2000-08-01
BR9909626A (pt)	2002-01-15
WO1999052898A1 (en)	1999-10-21
US6262084B1 (en)	2001-07-17
ATE402170T1 (de)	2008-08-15
NO20005162D0 (no)	2000-10-13
TR200100141T2 (tr)	2001-06-21
HUP0103752A3 (en)	2002-11-28
AU3563799A (en)	1999-11-01
BR9909625A (pt)	2002-01-15
IL138972A0 (en)	2001-11-25
PL343770A1 (en)	2001-09-10
CN1305473A (zh)	2001-07-25
CA2328990A1 (en)	1999-10-21
CA2328234C (en)	2009-03-17
WO1999052493A3 (en)	2000-12-28
EP1079825A4 (en)	2003-03-05
JP4753403B2 (ja)	2011-08-24
EP1071680B1 (en)	2008-07-23
DE69942610D1 (de)	2010-09-02
HUP0103752A2 (hu)	2002-07-29
JP4949552B2 (ja)	2012-06-13
NO20005162L (no)	2000-12-15
EP1079825B1 (en)	2010-07-21
TR200100139T2 (tr)	2001-06-21
CN1311676A (zh)	2001-09-05
SK15602000A3 (sk)	2001-03-12
HUP0101419A2 (hu)	2002-04-29
HUP0101419A3 (en)	2002-08-28
CA2328234A1 (en)	1999-10-21
CA2328990C (en)	2011-01-11
NO20005161L (no)	2000-12-15
JP2002511463A (ja)	2002-04-16
AU3748399A (en)	1999-11-01
EP1071680A4 (en)	2003-03-05
WO1999052493A2 (en)	1999-10-21
ES2345471T3 (es)	2010-09-23
EP1079825A2 (en)	2001-03-07
KR20010042704A (ko)	2001-05-25
SK15592000A3 (sk)	2001-12-03

Publication	Publication Date	Title
NO20005161D0 (no)	2000-10-13	N,N-disubstituerte amider som inhiberer bindingen av integriner til deres reseptorer
DK1176956T3 (da)	2008-05-26	Carboxylsyrederivater, som inhiberer bindingen af integriner til deres receptorer
NO20015394L (no)	2002-05-07	Karboksylsyrederivater som hemmer bindingen av integriner til deres reseptorer
ATE420876T1 (de)	2009-01-15	Propansäurederivate die die bindung von integrinen an ihre rezeptoren hemmen
NO20015419L (no)	2001-12-20	Propionsyrederivater som hemmer binding av integriner til deres reseptorer
CA2361285A1 (en)	2003-04-09	Propanoic acid derivatives that inhibit the binding of integrins to their receptors

Legal Events

Date	Code	Title	Description
2002-12-16	FC2A	Withdrawal, rejection or dismissal of laid open patent application