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NL7514164A - Werkwijze voor het bereiden van gesubstitueerde pyridinen. - Google Patents

Werkwijze voor het bereiden van gesubstitueerde pyridinen.

Info

Publication number
NL7514164A
NL7514164A NL7514164A NL7514164A NL7514164A NL 7514164 A NL7514164 A NL 7514164A NL 7514164 A NL7514164 A NL 7514164A NL 7514164 A NL7514164 A NL 7514164A NL 7514164 A NL7514164 A NL 7514164A
Authority
NL
Netherlands
Prior art keywords
pyridins
preparing substituted
substituted
preparing
substituted pyridins
Prior art date
Application number
NL7514164A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL7514164A publication Critical patent/NL7514164A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL7514164A 1974-12-16 1975-12-04 Werkwijze voor het bereiden van gesubstitueerde pyridinen. NL7514164A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/533,385 US4000282A (en) 1974-12-16 1974-12-16 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US05/713,558 US4096151A (en) 1974-12-16 1976-08-11 Certain 3-cyanopyridine intermediates

Publications (1)

Publication Number Publication Date
NL7514164A true NL7514164A (nl) 1976-06-18

Family

ID=27064163

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7514164A NL7514164A (nl) 1974-12-16 1975-12-04 Werkwijze voor het bereiden van gesubstitueerde pyridinen.

Country Status (11)

Country Link
US (3) US4000282A (nl)
JP (1) JPS5186473A (nl)
AU (1) AU502129B2 (nl)
BE (1) BE836627A (nl)
CA (1) CA1064499A (nl)
DE (2) DE2556110C3 (nl)
FR (1) FR2294702A1 (nl)
GB (2) GB1496579A (nl)
LU (1) LU74000A1 (nl)
NL (1) NL7514164A (nl)
SE (1) SE7513571L (nl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091104A (en) * 1976-06-15 1978-05-23 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
US4053605A (en) * 1976-06-15 1977-10-11 Merck & Co., Inc. Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
US4294966A (en) * 1978-07-28 1981-10-13 Ciba-Geigy Corporation Process for inverting the configuration in optically active compounds
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4234590A (en) * 1979-02-05 1980-11-18 Merck & Co., Inc. Thiosubstituted pyridines
US4259327A (en) * 1979-04-02 1981-03-31 Merck & Co., Inc. Substituted aminoalkoxypyridines, compositions and use thereof
US4329351A (en) * 1979-10-01 1982-05-11 Merck & Co., Inc. 2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates
DE2943774A1 (de) * 1979-10-26 1981-05-14 1000 Berlin Schering Ag Berlin Und Bergkamen Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung
US4254263A (en) * 1979-11-02 1981-03-03 Merck & Co., Inc. Process for purifying a cyanopyridine compound
US4331679A (en) * 1980-12-23 1982-05-25 Merck Sharp & Dohme (I.A.) Corp. (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
US4442094A (en) * 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4436740A (en) * 1982-07-26 1984-03-13 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines
US4550117A (en) * 1982-07-26 1985-10-29 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines, derivatives thereof, having anti-hypertensive activity
ES523901A0 (es) * 1983-07-06 1985-04-01 Fabr Prod Quimicos Y Farmaceut Un procedimiento para la preparacion de derivados de 3-sulfonamidopiridinas 2 -sustituidas.
WO1999061055A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
CN104208718B (zh) 2009-02-20 2017-12-29 2-Bbb医疗股份有限公司 基于谷胱甘肽的药物递送系统
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
DE1919342A1 (de) 1969-04-16 1970-12-03 Boehringer Sohn Ingelheim Herzwirksame Kombinationspraeparate
AR207133A1 (es) * 1973-02-20 1976-09-15 Ciba Geigy Ag Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4053605A (en) * 1976-06-15 1977-10-11 Merck & Co., Inc. Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

Also Published As

Publication number Publication date
DE2556110C3 (de) 1979-02-22
LU74000A1 (nl) 1976-11-11
DE2556110B2 (de) 1978-06-15
BE836627A (fr) 1976-06-15
AU502129B2 (en) 1979-07-12
JPS5186473A (nl) 1976-07-29
US4000282A (en) 1976-12-28
DE2556110A1 (de) 1976-06-24
SE7513571L (sv) 1976-06-17
US4096151A (en) 1978-06-20
DE2559755A1 (de) 1977-11-03
FR2294702A1 (fr) 1976-07-16
GB1496579A (en) 1977-12-30
US4139535A (en) 1979-02-13
GB1496580A (en) 1977-12-30
CA1064499A (en) 1979-10-16
FR2294702B1 (nl) 1979-09-28
AU8743675A (en) 1977-06-16

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Legal Events

Date Code Title Description
BV The patent application has lapsed