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MXPA03001654A - Proceso para la elaboracion del acido n-aril-antranilico y sus derivados. - Google Patents

Proceso para la elaboracion del acido n-aril-antranilico y sus derivados.

Info

Publication number
MXPA03001654A
MXPA03001654A MXPA03001654A MXPA03001654A MXPA03001654A MX PA03001654 A MXPA03001654 A MX PA03001654A MX PA03001654 A MXPA03001654 A MX PA03001654A MX PA03001654 A MXPA03001654 A MX PA03001654A MX PA03001654 A MXPA03001654 A MX PA03001654A
Authority
MX
Mexico
Prior art keywords
aryl
derivatives
making
anthranilic acids
preparation
Prior art date
Application number
MXPA03001654A
Other languages
English (en)
Spanish (es)
Inventor
Derick Dale Winkle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MXPA03001654A publication Critical patent/MXPA03001654A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
MXPA03001654A 2000-08-25 2001-07-20 Proceso para la elaboracion del acido n-aril-antranilico y sus derivados. MXPA03001654A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Publications (1)

Publication Number Publication Date
MXPA03001654A true MXPA03001654A (es) 2004-09-10

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03001654A MXPA03001654A (es) 2000-08-25 2001-07-20 Proceso para la elaboracion del acido n-aril-antranilico y sus derivados.

Country Status (31)

Country Link
EP (1) EP1313694A1 (no)
JP (1) JP2004507518A (no)
KR (1) KR20030059115A (no)
CN (1) CN1458921A (no)
AP (1) AP2001002249A0 (no)
AR (1) AR032175A1 (no)
AU (1) AU2001277044A1 (no)
BG (1) BG107635A (no)
BR (1) BR0113520A (no)
CA (1) CA2420003A1 (no)
CZ (1) CZ2003477A3 (no)
DO (1) DOP2001000238A (no)
EA (1) EA200300187A1 (no)
GT (1) GT200100174A (no)
HN (1) HN2001000216A (no)
HU (1) HUP0300828A2 (no)
IL (1) IL154507A0 (no)
IS (1) IS6724A (no)
MA (1) MA26949A1 (no)
MX (1) MXPA03001654A (no)
NO (1) NO20030844L (no)
PA (1) PA8526501A1 (no)
PE (1) PE20020393A1 (no)
PL (1) PL360699A1 (no)
SK (1) SK2072003A3 (no)
SV (1) SV2002000601A (no)
TN (1) TNSN01127A1 (no)
UY (1) UY26908A1 (no)
WO (1) WO2002018319A1 (no)
YU (1) YU14303A (no)
ZA (1) ZA200301182B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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NZ535158A (en) 2002-03-13 2007-06-29 Array Biopharma Inc N3 alkylated benzimidazole derivatives as MEK inhibitors
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
KR101013932B1 (ko) 2003-10-21 2011-02-14 워너-램버트 캄파니 엘엘씨 N-[(r)-2,3-디히드록시-프로폭시]-3,4-디플루오로-2-(2-플루오로-4-요오도페닐아미노)-벤자미드 다형체 형태
CA2545659C (en) 2003-11-19 2013-06-04 Array Biopharma Inc. Bicyclic inhibitors of mek
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
NZ547327A (en) 2003-11-21 2009-08-28 Array Biopharma Inc AKT protein kinase inhibitors
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
NZ562199A (en) 2005-04-13 2010-12-24 Astex Therapeutics Ltd Hydroxybenzamide derivatives and their use as inhibitors of HSP90
SA06270141B1 (ar) 2005-05-18 2009-11-15 اراي بيوفارما انك مثبطات حلقية غير متجانسة لـmek وطرق استخدامها
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
RS52210B (en) 2006-07-06 2012-10-31 Array Biopharma, Inc. CYCLOPENT [D] PYRIMIDINS AS PROTEIN KINASE ACTION INHIBITORS
US9303040B2 (en) 2006-07-06 2016-04-05 Array Biopharma Inc. Substituted piperazines as AKT inhibitors
CA2656566C (en) 2006-07-06 2014-06-17 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2073802A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044054A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in therapy
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8779132B2 (en) 2006-10-12 2014-07-15 Astex Therapeutics Limited Pharmaceutical compounds
CA2692506C (en) 2007-07-05 2015-11-24 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
AU2008272830B8 (en) 2007-07-05 2013-12-12 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101932564B (zh) 2008-01-09 2012-12-26 阵列生物制药公司 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类
BRPI0907372A2 (pt) 2008-01-09 2015-07-14 Array Biopharma Inc Pirimidil ciclopentano hidroxilado como inibidor de proteína quinase akt
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
CA2789361A1 (en) * 2010-02-19 2011-08-25 Jacques Mortier Method for preparing chemical compounds of interest by aromatic nucleophilic substitution
CA2789373A1 (en) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Process for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group
AU2012236166A1 (en) 2011-04-01 2013-11-14 Genentech, Inc. Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use
EP2694073B1 (en) 2011-04-01 2018-08-08 Genentech, Inc. Combinations of akt and mek inhibitors for treating cancer
IN2015DN03928A (no) * 2012-10-12 2015-10-02 Exelixis Inc
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
WO1998037881A1 (en) * 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
ES2274572T3 (es) * 1997-07-01 2007-05-16 Warner-Lambert Company Llc Derivados de acido 2-(4-bromo- o 4-yodo-fenilamino) benzoico y su uso como inhibidor de mek.
CA2290506C (en) * 1997-07-01 2005-12-27 Warner-Lambert Company 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
OA11861A (en) * 1999-04-21 2006-03-02 Warner Lambert Co Method for making 2-(N-phenylamino) benzoic acids.

Also Published As

Publication number Publication date
WO2002018319A1 (en) 2002-03-07
AP2001002249A0 (en) 2001-09-30
CA2420003A1 (en) 2002-03-07
CZ2003477A3 (cs) 2003-10-15
HUP0300828A2 (hu) 2003-09-29
YU14303A (sh) 2006-08-17
PE20020393A1 (es) 2002-05-09
CN1458921A (zh) 2003-11-26
IL154507A0 (en) 2003-09-17
GT200100174A (es) 2002-07-18
PA8526501A1 (es) 2002-07-30
ZA200301182B (en) 2004-05-12
PL360699A1 (en) 2004-09-20
SV2002000601A (es) 2002-04-03
JP2004507518A (ja) 2004-03-11
AR032175A1 (es) 2003-10-29
KR20030059115A (ko) 2003-07-07
AU2001277044A1 (en) 2002-03-13
DOP2001000238A (es) 2003-01-31
EP1313694A1 (en) 2003-05-28
BR0113520A (pt) 2003-06-24
EA200300187A1 (ru) 2003-08-28
NO20030844L (no) 2003-02-25
BG107635A (bg) 2004-09-30
MA26949A1 (fr) 2004-12-20
TNSN01127A1 (en) 2005-11-10
SK2072003A3 (en) 2004-01-08
UY26908A1 (es) 2001-11-30
NO20030844D0 (no) 2003-02-24
IS6724A (is) 2003-02-20
HN2001000216A (es) 2002-05-22

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