MX9206306A - Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene. - Google Patents

Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene.

Info

Publication number: MX9206306A
Authority: MX; Mexico
Prior art keywords: peptides; procedure; production; pharmaceutical composition; pharmaceutical
Prior art date: 1991-11-04

Application number

MX9206306A

Other languages

English (en)

Inventor

Richard Heng

Trevor Glyn Payne

Laszlo Revesz

Beat Weidmann

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-04

Filing date

1992-11-03

Publication date

1993-05-01

1992-11-03 Application filed by Sandoz Ag filed Critical Sandoz Ag

1993-05-01 Publication of MX9206306A publication Critical patent/MX9206306A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Crystallography & Structural Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MX9206306A 1991-11-04 1992-11-03 Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene. MX9206306A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919123326A GB9123326D0 (en)	1991-11-04	1991-11-04	Improvements in or relating to organic compounds

Publications (1)

Publication Number	Publication Date
MX9206306A true MX9206306A (es)	1993-05-01

Family

ID=10703998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX9206306A MX9206306A (es)	1991-11-04	1992-11-03	Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene.

Country Status (16)

Country	Link
EP (1)	EP0611375A1 (es)
JP (1)	JPH07500828A (es)
AU (1)	AU2885292A (es)
CA (1)	CA2116653A1 (es)
CZ (1)	CZ106794A3 (es)
FI (1)	FI942061A0 (es)
GB (1)	GB9123326D0 (es)
HU (1)	HUT68200A (es)
IL (1)	IL103612A0 (es)
MX (1)	MX9206306A (es)
NO (1)	NO941629L (es)
NZ (1)	NZ244985A (es)
PT (1)	PT101027A (es)
SK (1)	SK51194A3 (es)
WO (1)	WO1993009135A1 (es)
ZA (1)	ZA928511B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
DE69226820T2 (de) *	1991-06-21	1999-05-12	Merck & Co., Inc., Rahway, N.J.	Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen
AU3666893A (en) *	1992-02-21	1993-09-13	Merck & Co., Inc.	Peptidyl derivatives as inhibitors of interleukin-1beta converting enzyme
EP0618223A3 (en) *	1993-03-08	1996-06-12	Sandoz Ltd	Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
US5985838A (en) *	1993-04-29	1999-11-16	Vertex Pharmaceuticals, Inc.	Peptide analogs as irreversible interleukin-1β protease inhibitors
TW494094B (en) *	1993-04-29	2002-07-11	Vertex Pharma	Peptide analogs as irreversible interleukin-1β protease inhibitors and pharmaceutical compositions comprising the same
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) *	1993-06-03	1995-04-04	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
US5843905A (en) *	1993-06-04	1998-12-01	Vertex Pharmaceuticals, Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
JPH0725887A (ja) *	1993-06-04	1995-01-27	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
AU7714594A (en) *	1993-08-13	1995-03-14	Merck & Co., Inc.	Substituted ketone derivatives as inhibitors of interleukin-1beta converting enzyme
US5714484A (en) *	1993-12-08	1998-02-03	Prototek, Inc.	α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5486623A (en) *	1993-12-08	1996-01-23	Prototek, Inc.	Cysteine protease inhibitors containing heterocyclic leaving groups
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5756466A (en)	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5565430A (en) *	1994-08-02	1996-10-15	Sterling Winthrop Inc.	Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors
GB2292149A (en) *	1994-08-09	1996-02-14	Ferring Res Ltd	Peptide inhibitors of pro-interleukin-1beta converting enzyme
CA2215211A1 (en) *	1995-03-31	1996-10-03	Takeda Chemical Industries, Ltd.	Cysteine protease inhibitor
US5798442A (en) *	1995-04-21	1998-08-25	Merck Frosst Canada, Inc.	Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
EP0761680A3 (en) *	1995-09-12	1999-05-06	Ono Pharmaceutical Co., Ltd.	Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
EP0900791A1 (en) *	1995-12-27	1999-03-10	Ono Pharmaceutical Co., Ltd.	Tetrazole derivatives and drugs containing the same as the active ingredient
US5869519A (en) *	1996-12-16	1999-02-09	Idun Pharmaceuticals, Inc.	C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5968927A (en)	1996-09-20	1999-10-19	Idun Pharmaceuticals, Inc.	Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US5877197A (en) *	1996-12-16	1999-03-02	Karanewsky; Donald S.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en) *	1996-12-16	2001-02-06	Idun Pharmaceuticals, Inc.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
CN1252716A (zh) *	1997-02-26	2000-05-10	西布莱克斯公司	无前导序列蛋白输出的抑制剂
US6306613B1 (en)	1997-02-26	2001-10-23	Ciblex Corporation	Modulators of leaderless protein export and methods for identifying and using the same
DE69925581T2 (de)	1998-03-09	2006-04-27	Vertex Pharmaceuticals Inc., Cambridge	1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
BR9909660A (pt)	1998-03-19	2000-11-21	Vertex Pharma	Inibidores de caspases
US6242422B1 (en)	1998-10-22	2001-06-05	Idun Pharmacueticals, Inc.	(Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en)	1998-10-22	2007-01-02	Idun Pharmaceuticals, Inc.	(Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
EP1177168B1 (en) *	1999-04-09	2007-05-30	Cytovia, Inc.	Caspase inhibitors and the use thereof
US6525024B1 (en)	2000-04-17	2003-02-25	Idun Pharmaceuticals, Inc.	Inhibitors of the ICE/ced-3 family of cysteine proteases
US20010053764A1 (en)	2000-05-12	2001-12-20	Sims John E.	Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2002022611A2 (en) *	2000-09-13	2002-03-21	Vertex Pharmaceuticals Incorporated	Caspase inhibitors and uses thereof
US7087604B2 (en)	2002-03-08	2006-08-08	Bristol-Myers Squibb Company	Cyclic derivatives as modulators of chemokine receptor activity
DK2399915T3 (en)	2004-03-12	2015-03-09	Vertex Pharma	A process and intermediates for the preparation of asparaginacetal-caspase inhibitors
EP1778221A2 (en)	2004-05-27	2007-05-02	Vertex Pharmaceuticals Incorporated	Ice inhibitors for the treatment of autoinflammatory diseases
CN101979403A (zh) *	2010-09-13	2011-02-23	沈陵陵	新型半胱氨酸天冬氨酸广谱蛋白酶抑制剂及其制备方法和用途
JP6006908B2 (ja)	2010-11-05	2016-10-12	ブランダイスユニバーシティＢｒａｎｄｅｉｓＵｎｉｖｅｒｓｉｔｙ	Ｉｃｅ阻害化合物およびその使用
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS
CN108473499B (zh)	2015-11-13	2021-07-23	诺华股份有限公司	新颖的吡唑并嘧啶衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7775991A (en) *	1990-04-04	1991-10-30	Immunex Corporation	Interleukin 1beta protease

1991
- 1991-11-04 GB GB919123326A patent/GB9123326D0/en active Pending
1992
- 1992-10-29 AU AU28852/92A patent/AU2885292A/en not_active Abandoned
- 1992-10-29 JP JP5508146A patent/JPH07500828A/ja active Pending
- 1992-10-29 CA CA002116653A patent/CA2116653A1/en not_active Abandoned
- 1992-10-29 HU HU9401303A patent/HUT68200A/hu active IP Right Revival
- 1992-10-29 EP EP92922580A patent/EP0611375A1/en not_active Withdrawn
- 1992-10-29 CZ CZ941067A patent/CZ106794A3/cs unknown
- 1992-10-29 WO PCT/EP1992/002472 patent/WO1993009135A1/en not_active Application Discontinuation
- 1992-10-29 SK SK511-94A patent/SK51194A3/sk unknown
- 1992-11-02 NZ NZ244985A patent/NZ244985A/en unknown
- 1992-11-02 IL IL103612A patent/IL103612A0/xx unknown
- 1992-11-02 PT PT101027A patent/PT101027A/pt not_active Application Discontinuation
- 1992-11-03 MX MX9206306A patent/MX9206306A/es unknown
- 1992-11-04 ZA ZA928511A patent/ZA928511B/xx unknown
1994
- 1994-05-03 NO NO941629A patent/NO941629L/no unknown
- 1994-05-04 FI FI942061A patent/FI942061A0/fi unknown

Also Published As

Publication number	Publication date
NO941629D0 (no)	1994-05-03
GB9123326D0 (en)	1991-12-18
HU9401303D0 (en)	1994-08-29
FI942061A (fi)	1994-05-04
WO1993009135A1 (en)	1993-05-13
EP0611375A1 (en)	1994-08-24
HUT68200A (en)	1995-05-29
IL103612A0 (en)	1993-04-04
CA2116653A1 (en)	1993-05-13
JPH07500828A (ja)	1995-01-26
CZ106794A3 (en)	1994-12-15
NO941629L (no)	1994-07-04
PT101027A (pt)	1994-02-28
SK51194A3 (en)	1995-02-08
ZA928511B (en)	1994-05-04
NZ244985A (en)	1995-06-27
AU2885292A (en)	1993-06-07
FI942061A0 (fi)	1994-05-04

Publication	Publication Date	Title
MX9206306A (es)	1993-05-01	Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene.
MX9206938A (es)	1993-06-01	Nuevos derivados peptidos, proceso para su preparacion y preparacion farmaceutica que comprende tales derivados.
MX9201141A (es)	1992-10-01	Ciclosporinas cristalinas, procedimiento para su produccion y composicion farmaceutica que las contiene.
MX9202748A (es)	1992-12-01	Compuesto de arileter, proceso para su obtencion y composicion farmaceutica que los contiene.
MX9200324A (es)	1992-09-01	Nuevos esteroides, procedimiento para su preparacinuevos esteroides, procedimiento para su preparacion y composicion farmaceutica que los contiene. on y composicion farmaceutica que los contiene.
MX9205280A (es)	1993-03-01	Derivados de benzanilida, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9200374A (es)	1992-08-01	Nuevos esteres esteroides, procedimiento para su preparacion y preparacion farmaceutica que los contiene.
MX9204767A (es)	1993-05-01	Nuevos peptidos isostericos, proceso para su preparacion y composicion farmaceutica que los contiene
MX9202289A (es)	1993-02-01	Nuevos derivados de tiopiranopirrol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
MX9202982A (es)	1992-12-01	Derivados de los acidos quinolon - y naftiridon - carboxilicos, procedimiento para su obtencion y medicamentos que los contienen.
MX9102580A (es)	1992-06-01	Nuevas benzodiacepinonas, procedimiento para su preparacion y composicion farmaceutica que las contiene.
MX9102500A (es)	1992-06-01	Compuestos de bifenilio, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9201295A (es)	1992-10-01	Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contienen.
MX9201058A (es)	1992-09-01	Derivados ciclicos de cetal, procedimiento para supreparacion y composicion farmaceutica que los contiene.
MX9202152A (es)	1992-11-01	Derivados del indol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9201847A (es)	1992-10-01	Derivados heterociclicos de antiserotoninas, procedimiento para su preparacion y medicamentos que los contienen.
MX24890A (es)	1993-12-01	Polipeptido sintetico, procedimiento par su preparacion y composicion farmaceutica que lo contiene.
MX9202300A (es)	1992-11-01	Derivados de benzofurano, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9201780A (es)	1992-10-01	Eteres oximicos y procedimiento para su preparacion.
MX9201848A (es)	1992-10-01	Antiserotoninas, procedimiento para su preparacion y medicamentos que las contienen.
MX9204395A (es)	1993-02-01	Derivados de 3-desoxi-manosamina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
MX9207269A (es)	1993-06-01	Bencimidazoles substituidos, proceso para su preparacion y composiciones farmaceuticas que los contienen.
MX9102499A (es)	1992-06-01	Derivados de benzamida, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9205747A (es)	1993-04-01	Pirazolinas y procedimiento para su preparacion.
MX9200996A (es)	1992-09-01	Compuestos heterociclicos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.