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MX3211E - PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINE - Google Patents

PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINE

Info

Publication number
MX3211E
MX3211E MX29876U MX29876U MX3211E MX 3211 E MX3211 E MX 3211E MX 29876 U MX29876 U MX 29876U MX 29876 U MX29876 U MX 29876U MX 3211 E MX3211 E MX 3211E
Authority
MX
Mexico
Prior art keywords
see
formula
preparation
substituted quinazoline
reagents
Prior art date
Application number
MX29876U
Other languages
Spanish (es)
Inventor
Louis Leonard Skaletzky
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX3211E publication Critical patent/MX3211E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a procedimiento para la preparación de quinazolina substituída, de la fórmula: (VER FIGURA) en donde X e Y se localizan en la posición 6, 7 ú 8 y son iguales o diferentes y se seleccionan del grupo que consiste de hidrógeno, alquilo con de 1 a 6 átomos de carbono inclusive, alcoxi con de 1 a 6 átomos de carbono, inclusive, halógeno; n es 1 ó 2; o una sal de adición de ácido fisiológicamente aceptable, que comprende hacer reaccionar una 1,2-dihidro-2,2,4-trimetilquinolina de la fórmula: (VER FIGURA) o una de sus sales de adición de ácido en donde X e Y tienen las limitaciones antriores, con una N-cianoamina de la fórmula: (VER FIGURA) en donde n es 1 ó 2, en la presencia de un disolvente inerte a los reactivos y producto, y solubiliza los reactivos, y una cantidad catalítica de un ácido mineral fuerte a una temperatura elevada.The present invention relates to a process for the preparation of substituted quinazoline, of the formula: (SEE FIGURE) where X and Y are located at position 6, 7 or 8 and are the same or different and are selected from the group consisting of hydrogen, alkyl with 1 to 6 carbon atoms inclusive, alkoxy with 1 to 6 carbon atoms, inclusive, halogen; n is 1 or 2; or a physiologically acceptable acid addition salt, comprising reacting a 1,2-dihydro-2,2,4-trimethylquinoline of the formula: (SEE FIGURE) or one of its acid addition salts wherein X and Y have the above limitations, with an N-cyanoamine of the formula: (SEE FIGURE) where n is 1 or 2, in the presence of a solvent inert to the reagents and product, and solubilizes the reagents, and a catalytic amount of a strong mineral acid at an elevated temperature.

MX29876U 1975-07-16 1976-06-10 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINE MX3211E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59628175A 1975-07-16 1975-07-16

Publications (1)

Publication Number Publication Date
MX3211E true MX3211E (en) 1980-07-11

Family

ID=24386703

Family Applications (1)

Application Number Title Priority Date Filing Date
MX29876U MX3211E (en) 1975-07-16 1976-06-10 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINE

Country Status (5)

Country Link
JP (1) JPS5212183A (en)
CA (1) CA1036162A (en)
CH (1) CH605922A5 (en)
DK (1) DK141626B (en)
MX (1) MX3211E (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5737268U (en) * 1980-08-08 1982-02-27
US4584413A (en) * 1983-09-14 1986-04-22 Atlantic Richfield Company Purification of tertiary butyl hydroperoxide containing primary and secondary alkyl hydroperoxide contaminants
US5600026A (en) * 1992-05-27 1997-02-04 Sumitomo Chemical Company, Limited Process for production of cresols
JPH0827104A (en) * 1994-07-14 1996-01-30 Sumitomo Chem Co Ltd Treatment of hydroperoxide mixture

Also Published As

Publication number Publication date
CH605922A5 (en) 1978-10-13
DK284476A (en) 1977-01-17
JPS5212183A (en) 1977-01-29
DK141626C (en) 1980-10-13
DK141626B (en) 1980-05-12
CA1036162A (en) 1978-08-08

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