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MX2021002299A - Anticuerpos de anti-cd33 y metodos para usarlos. - Google Patents

Anticuerpos de anti-cd33 y metodos para usarlos.

Info

Publication number
MX2021002299A
MX2021002299A MX2021002299A MX2021002299A MX2021002299A MX 2021002299 A MX2021002299 A MX 2021002299A MX 2021002299 A MX2021002299 A MX 2021002299A MX 2021002299 A MX2021002299 A MX 2021002299A MX 2021002299 A MX2021002299 A MX 2021002299A
Authority
MX
Mexico
Prior art keywords
antibodies
methods
compositions
monoclonal
mammalian
Prior art date
Application number
MX2021002299A
Other languages
English (en)
Inventor
Wei- Hsien Ho
Arnon Rosenthal
Helen Lam
Patricia Culp
Leonard Presta
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of MX2021002299A publication Critical patent/MX2021002299A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente descripción se dirige, en líneas generales, a composiciones que incluyen anticuerpos, por ejemplo, anticuerpos monoclonales, fragmentos de anticuerpos, etc., que se unen específicamente a un polipéptido CD33, por ejemplo, una CD33 de mamífero o CD33 humana, y el uso de estas composiciones para prevenir, reducir el riesgo o tratar a un individuo que lo necesite.
MX2021002299A 2018-08-31 2019-08-30 Anticuerpos de anti-cd33 y metodos para usarlos. MX2021002299A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862726053P 2018-08-31 2018-08-31
PCT/US2019/048994 WO2020047374A1 (en) 2018-08-31 2019-08-30 Anti-cd33 antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2021002299A true MX2021002299A (es) 2021-04-28

Family

ID=67957407

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021002299A MX2021002299A (es) 2018-08-31 2019-08-30 Anticuerpos de anti-cd33 y metodos para usarlos.

Country Status (21)

Country Link
US (1) US20210317208A1 (es)
EP (1) EP3843851A1 (es)
KR (1) KR20210070986A (es)
CN (2) CN113801229A (es)
AR (1) AR119259A1 (es)
AU (1) AU2019331018A1 (es)
BR (1) BR112021003016A2 (es)
CA (1) CA3108808A1 (es)
CL (1) CL2021000501A1 (es)
CO (1) CO2021003078A2 (es)
CR (1) CR20210155A (es)
EA (1) EA202190235A1 (es)
EC (1) ECSP21022299A (es)
IL (1) IL281008A (es)
MA (1) MA53492A (es)
MX (1) MX2021002299A (es)
PE (1) PE20211096A1 (es)
PH (1) PH12021550332A1 (es)
SG (1) SG11202101552SA (es)
TW (1) TW202016307A (es)
WO (1) WO2020047374A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
CR20190486A (es) 2017-08-03 2020-02-10 Alector Llc Anti-cd33 antibodies and methods of use thereof
PE20211096A1 (es) * 2018-08-31 2021-06-14 Alector Llc Anticuerpos anti-cd33 y metodos para usarlos
WO2023081898A1 (en) 2021-11-08 2023-05-11 Alector Llc Soluble cd33 as a biomarker for anti-cd33 efficacy
WO2024026318A2 (en) * 2022-07-25 2024-02-01 Rhode Island Hospital Diagnosis, prognosis and treatment of malignant neoplasms
CN115724959B (zh) * 2022-11-11 2023-06-20 杭州华葵金配生物科技有限公司 靶向甲型流感病毒核蛋白的抗体及其应用

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Also Published As

Publication number Publication date
BR112021003016A2 (pt) 2021-05-18
MA53492A (fr) 2021-09-15
AU2019331018A1 (en) 2021-03-11
EP3843851A1 (en) 2021-07-07
IL281008A (en) 2021-04-29
US20210317208A1 (en) 2021-10-14
SG11202101552SA (en) 2021-03-30
ECSP21022299A (es) 2021-04-29
JP2021534797A (ja) 2021-12-16
CN112912144A (zh) 2021-06-04
TW202016307A (zh) 2020-05-01
CR20210155A (es) 2021-05-10
WO2020047374A1 (en) 2020-03-05
CN113801229A (zh) 2021-12-17
KR20210070986A (ko) 2021-06-15
CL2021000501A1 (es) 2021-07-23
AR119259A1 (es) 2021-12-09
CO2021003078A2 (es) 2021-03-19
PE20211096A1 (es) 2021-06-14
PH12021550332A1 (en) 2021-10-04
CA3108808A1 (en) 2020-03-05
EA202190235A1 (ru) 2021-07-02

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