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MX2019010196A - Composiciones y métodos para la inhibición de proteínas específicas del linaje. - Google Patents

Composiciones y métodos para la inhibición de proteínas específicas del linaje.

Info

Publication number
MX2019010196A
MX2019010196A MX2019010196A MX2019010196A MX2019010196A MX 2019010196 A MX2019010196 A MX 2019010196A MX 2019010196 A MX2019010196 A MX 2019010196A MX 2019010196 A MX2019010196 A MX 2019010196A MX 2019010196 A MX2019010196 A MX 2019010196A
Authority
MX
Mexico
Prior art keywords
compositions
methods
inhibition
specific proteins
lineage specific
Prior art date
Application number
MX2019010196A
Other languages
English (en)
Inventor
Bolen Joseph
Filip RADOVIC - MORENO Aleksandar
Lydeard John
Original Assignee
Vor Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vor Biopharma Inc filed Critical Vor Biopharma Inc
Publication of MX2019010196A publication Critical patent/MX2019010196A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Abstract

Descritos en la presente son composiciones, métodos y kits para su uso en el tratamiento de malignidades hematopoyéticas; las composiciones, métodos y kits comprenden un agente citotóxico que focaliza a células que expresan una proteína de la superficie de la célula específica del linaje y una población de células hematopoyéticas que expresan la proteína de la superficie de la célula específica del linaje, las células hematopoyéticas siendo manipuladas de modo que no se unen al agente citotóxico.
MX2019010196A 2017-02-28 2018-02-28 Composiciones y métodos para la inhibición de proteínas específicas del linaje. MX2019010196A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762464975P 2017-02-28 2017-02-28
PCT/US2018/020327 WO2018160768A1 (en) 2017-02-28 2018-02-28 Compositions and methods for inhibition lineage specific proteins

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MX2019010196A true MX2019010196A (es) 2019-12-19

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US (2) US11975029B2 (es)
EP (1) EP3589291A4 (es)
JP (2) JP7386082B2 (es)
KR (1) KR102709603B1 (es)
CN (1) CN110662554A (es)
AU (2) AU2018229351B2 (es)
BR (1) BR112019017751A2 (es)
CA (1) CA3054808A1 (es)
IL (1) IL268895A (es)
MX (1) MX2019010196A (es)
RU (1) RU2019130504A (es)
SG (1) SG11201907870VA (es)
WO (1) WO2018160768A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2962651T3 (es) 2015-10-16 2024-03-20 Univ Columbia Composiciones y métodos para la inhibición de antígenos específicos de linaje
EP3589291A4 (en) 2017-02-28 2020-11-25 Vor Biopharma, Inc. COMPOSITIONS AND METHODS OF INHIBITION OF LINE-SPECIFIC PROTEINS
US11718659B2 (en) * 2017-08-28 2023-08-08 The Trustees Of Columbia University In The City Of New York CD33 exon 2 deficient donor stem cells for use with CD33 targeting agents
JP2021523737A (ja) 2018-05-11 2021-09-09 ビーム セラピューティクス インク． プログラム可能塩基エディターシステムを用いて病原性アミノ酸を置換する方法
SG11202101994XA (en) 2018-08-28 2021-03-30 Vor Biopharma Inc Genetically engineered hematopoietic stem cells and uses thereof
US11866494B2 (en) * 2018-08-31 2024-01-09 Innovative Cellular Therapeutics Holdings, Ltd. CAR T therapy through uses of co-stimulation
JP2022520233A (ja) * 2019-02-13 2022-03-29 ビーム セラピューティクス インク． 標的配列中の核酸塩基を改変するためのアデノシンデアミナーゼ塩基エディターを有する改変された免疫細胞
US20220127594A1 (en) * 2019-02-13 2022-04-28 Beam Therapeutics Inc. Compositions and methods for treating glycogen storage disease type 1a
JP2022534813A (ja) 2019-05-23 2022-08-03 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ３３改変のための組成物および方法
AU2020338011A1 (en) 2019-08-28 2022-03-10 Vor Biopharma Inc. Compositions and methods for CLL1 modification
JP2022546505A (ja) 2019-08-28 2022-11-04 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ１２３改変ための組成物および方法
US11723926B2 (en) 2019-09-27 2023-08-15 Starkage Therapeutics Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
WO2021058795A2 (en) * 2019-09-27 2021-04-01 Stark Labs Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
WO2021081244A1 (en) * 2019-10-22 2021-04-29 Fred Hutchinson Cancer Research Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells
CA3172691A1 (en) * 2020-03-31 2021-10-07 Cameron J. Turtle Chimeric antigen receptors targeting cd33
US20240238344A1 (en) 2020-08-28 2024-07-18 Vor Biopharma Inc. Compositions and methods for cd123 modification
EP4204565A1 (en) 2020-08-28 2023-07-05 Vor Biopharma Inc. Compositions and methods for cll1 modification
JP2023541458A (ja) 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ５修飾のための化合物および方法
JP2023541457A (ja) 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ３８修飾のための化合物および方法
EP4214318A1 (en) 2020-09-18 2023-07-26 Vor Biopharma Inc. Compositions and methods for cd7 modification
US20230364233A1 (en) 2020-09-28 2023-11-16 Vor Biopharma Inc. Compositions and methods for cd6 modification
WO2022072643A1 (en) 2020-09-30 2022-04-07 Vor Biopharma Inc. Compositions and methods for cd30 gene modification
US20240344058A1 (en) 2020-10-30 2024-10-17 Vor Biopharma Inc. Compositions and methods for bcma modification
KR20230107610A (ko) * 2020-11-13 2023-07-17 보르 바이오파마 인크. 키메라 항원 수용체를 발현하는 유전적으로 조작된 세포와 관련된 방법 및 조성물
WO2022147347A1 (en) 2020-12-31 2022-07-07 Vor Biopharma Inc. Compositions and methods for cd34 gene modification
CN115443333A (zh) * 2021-04-27 2022-12-06 上海驯鹿生物技术有限公司 一种基因编辑的造血干细胞及其与car-t细胞的联合应用
JP2024530465A (ja) 2021-08-06 2024-08-21 ウニバズィテート バーゼル 細胞療法に使用するための識別可能な細胞表面タンパク質変異体
EP4430186A1 (en) 2021-11-09 2024-09-18 Vor Biopharma Inc. Compositions and methods for erm2 modification
CA3240527A1 (en) 2021-12-16 2023-06-22 Universitat Basel Discernible cell surface protein variants of cd117 for use in cell therapy
KR20240119146A (ko) 2021-12-23 2024-08-06 유니버시타트 바셀 세포 치료에 이용하기 위한 cd45의 식별 가능한 세포 표면 단백질 변이체
WO2024015925A2 (en) 2022-07-13 2024-01-18 Vor Biopharma Inc. Compositions and methods for artificial protospacer adjacent motif (pam) generation
CN116850210B (zh) * 2023-01-17 2024-05-31 武汉大学 用于治疗急性髓系白血病的成分和方法
WO2024208836A1 (en) 2023-04-03 2024-10-10 Universität Basel Discernible cell surface protein variants of cd33 for use in cell therapy

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968687B2 (en) 2007-10-19 2011-06-28 Seattle Genetics, Inc. CD19 binding agents and uses thereof
JP6073135B2 (ja) * 2009-10-19 2017-02-01 トライステム・トレイディング・（キプロス）・リミテッドＴｒｉＳｔｅｍ Ｔｒａｄｉｎｇ （Ｃｙｐｒｕｓ） Ｌｉｍｉｔｅｄ 再プログラム化成熟成体細胞を用いる治療
AU2011281062B2 (en) 2010-07-21 2015-01-22 Board Of Regents, The University Of Texas System Methods and compositions for modification of a HLA locus
US20130309223A1 (en) 2012-05-18 2013-11-21 Seattle Genetics, Inc. CD33 Antibodies And Use Of Same To Treat Cancer
GB2518764C (en) 2012-05-25 2016-08-24 Univ California Methods and compositions for RNA-directed target DNA modification
WO2014093694A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
WO2014191128A1 (en) 2013-05-29 2014-12-04 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
EP2833591A1 (en) 2013-07-31 2015-02-04 Siemens Aktiengesellschaft Subsea data communication interface unit
WO2015090229A1 (en) 2013-12-20 2015-06-25 Novartis Ag Regulatable chimeric antigen receptor
CA2937711C (en) 2014-02-14 2020-10-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
EP3569619B1 (en) 2014-03-19 2021-05-26 Cellectis Method of producing cd123 specific car t cells for cancer immunotherapy
DK3126390T3 (da) 2014-04-03 2020-01-20 Cellectis Cd33-specifikke kimære antigenreceptorer til cancerimmunterapi
EP3129485B2 (en) 2014-04-09 2022-12-21 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating cystic fibrosis
US20170044500A1 (en) 2014-04-24 2017-02-16 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
WO2015195547A1 (en) 2014-06-16 2015-12-23 University Of Washington Methods for controlling stem cell potential and for gene editing in stem cells
US9212225B1 (en) 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
BR112017001242A2 (pt) 2014-07-21 2017-12-05 Novartis Ag tratamento de câncer usando um receptor antigênico quimérico a cd33
CA2955465A1 (en) 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
CN113699113A (zh) 2014-09-16 2021-11-26 桑格摩治疗股份有限公司 用于造血干细胞中核酸酶介导的基因组工程化和校正的方法和组合物
KR101799975B1 (ko) 2014-10-31 2017-11-21 에스케이씨하이테크앤마케팅(유) 액정표시장치용 색순도 향상 및 휘도 보상 필름 및 이를 포함하는 액정표시장치
EP3025719B1 (en) 2014-11-26 2018-09-26 Miltenyi Biotec GmbH Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
EP3227447B1 (en) 2014-12-03 2024-04-24 Agilent Technologies, Inc. Guide rna with chemical modifications
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
JP2018504143A (ja) 2015-01-26 2018-02-15 セレクティスＣｅｌｌｅｃｔｉｓ がん免疫治療のための抗ｈｓｐ７０特異的キメラ抗原受容体（ｃａｒ）
WO2016164356A1 (en) 2015-04-06 2016-10-13 The Board Of Trustees Of The Leland Stanford Junior University Chemically modified guide rnas for crispr/cas-mediated gene regulation
ES2923894T3 (es) * 2015-04-08 2022-10-03 Novartis Ag Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
EP3173092B1 (en) 2015-04-22 2019-06-26 CureVac AG Rna containing composition for treatment of tumor diseases
GB201507119D0 (en) 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
JP6985934B2 (ja) * 2015-04-29 2021-12-22 フレッド ハッチンソン キャンサー リサーチ センター 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用
CA2986310A1 (en) 2015-05-11 2016-11-17 Editas Medicine, Inc. Optimized crispr/cas9 systems and methods for gene editing in stem cells
JP6996983B2 (ja) 2015-06-16 2022-02-21 ジェネンテック， インコーポレイテッド 抗ｃｌｌ－１抗体及び使用方法
ES2962651T3 (es) 2015-10-16 2024-03-20 Univ Columbia Composiciones y métodos para la inhibición de antígenos específicos de linaje
CN108699116A (zh) 2015-10-23 2018-10-23 哈佛大学的校长及成员们 用于基因编辑的演化的cas9蛋白
SG10202107602XA (en) * 2015-11-04 2021-08-30 Univ Pennsylvania Methods and compositions for gene editing in hematopoietic stem cells
WO2017091615A1 (en) 2015-11-24 2017-06-01 Cellerant Therapeutics, Inc. Humanized anti-cll-1 antibodies
WO2017172981A2 (en) 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer
CN116254231A (zh) 2016-04-25 2023-06-13 巴塞尔大学 等位基因编辑及其应用
KR20240111740A (ko) 2016-06-08 2024-07-17 프레시전 인코포레이티드 Cd33 특이적 키메라 항원 수용체
US10767175B2 (en) 2016-06-08 2020-09-08 Agilent Technologies, Inc. High specificity genome editing using chemically modified guide RNAs
CA3029197A1 (en) 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
WO2018007263A1 (en) 2016-07-06 2018-01-11 Cellectis Sequential gene editing in primary immune cells
CN110291102A (zh) 2016-10-21 2019-09-27 国立卫生和医学研究所 促进t细胞应答的方法
KR20190072639A (ko) * 2016-11-02 2019-06-25 유니버시타트 바셀 세포 치료에 사용하기 위한 면역학적으로 식별 가능한 세포 표면 변이체
MX2019007750A (es) 2016-12-30 2019-10-15 Editas Medicine Inc Moléculas guía sintéticas, composiciones y métodos relacionados con éstas.
EP3589291A4 (en) 2017-02-28 2020-11-25 Vor Biopharma, Inc. COMPOSITIONS AND METHODS OF INHIBITION OF LINE-SPECIFIC PROTEINS
WO2018165629A1 (en) 2017-03-10 2018-09-13 President And Fellows Of Harvard College Cytosine to guanine base editor
JP7191388B2 (ja) 2017-03-23 2022-12-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸によってプログラム可能なｄｎａ結合蛋白質を含む核酸塩基編集因子
CA3058790A1 (en) 2017-04-24 2018-11-01 Memorial Sloan Kettering Cancer Center Anti-cd33 antibody agents
US11718659B2 (en) 2017-08-28 2023-08-08 The Trustees Of Columbia University In The City Of New York CD33 exon 2 deficient donor stem cells for use with CD33 targeting agents
WO2019152591A1 (en) 2018-01-31 2019-08-08 Hydroacoustics Inc. Fluid sensor and pumpjack control system
WO2019157326A1 (en) 2018-02-08 2019-08-15 Zymergen Inc. Genome editing using crispr in corynebacterium
TWI669677B (zh) 2018-03-07 2019-08-21 光陽工業股份有限公司 充電座管理方法、用於充電座管理方法的伺服器及充電座
SG11202101994XA (en) 2018-08-28 2021-03-30 Vor Biopharma Inc Genetically engineered hematopoietic stem cells and uses thereof
KR20210089712A (ko) 2018-11-07 2021-07-16 크리스퍼 테라퓨틱스 아게 항-cd33 면역세포 암 치료법
CA3126677A1 (en) 2019-01-16 2020-07-23 The Trustees Of Columbia University In The City Of New York Compositions and methods for inhibition of lineage specific antigens
SG11202107555XA (en) 2019-01-16 2021-08-30 Beam Therapeutics Inc Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance
JP2022520233A (ja) 2019-02-13 2022-03-29 ビーム セラピューティクス インク． 標的配列中の核酸塩基を改変するためのアデノシンデアミナーゼ塩基エディターを有する改変された免疫細胞
JP2022534813A (ja) 2019-05-23 2022-08-03 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ３３改変のための組成物および方法
EA202191979A1 (ru) 2019-05-24 2021-11-01 Зе Трастис Оф Коламбия Юниверсити Ин Зе Сити Оф Нью-Йорк Композиции и способы ингибирования линиеспецифических антигенов
AU2020338011A1 (en) 2019-08-28 2022-03-10 Vor Biopharma Inc. Compositions and methods for CLL1 modification
JP2022546505A (ja) 2019-08-28 2022-11-04 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ１２３改変ための組成物および方法

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