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MX2017013199A - Composiciones para modular la expresion de c90rf72. - Google Patents

Composiciones para modular la expresion de c90rf72.

Info

Publication number
MX2017013199A
MX2017013199A MX2017013199A MX2017013199A MX2017013199A MX 2017013199 A MX2017013199 A MX 2017013199A MX 2017013199 A MX2017013199 A MX 2017013199A MX 2017013199 A MX2017013199 A MX 2017013199A MX 2017013199 A MX2017013199 A MX 2017013199A
Authority
MX
Mexico
Prior art keywords
compositions
c9orf72 expression
modulating
modulating c9orf72
methods
Prior art date
Application number
MX2017013199A
Other languages
English (en)
Other versions
MX366128B (es
Inventor
Rigo Frank
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2017013199A publication Critical patent/MX2017013199A/es
Publication of MX366128B publication Critical patent/MX366128B/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/22—Anxiolytics
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/30—Chemical structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

En la presente se describen composiciones y métodos para reducir la expresión de proteína y ARNm de C9ORF72 en un animal. Estos métodos son útiles para tratar, prevenir, mejorar o enlentecer el avance de enfermedades neurodegenerativas en un individuo que lo necesite.
MX2017013199A 2015-04-16 2016-04-15 Composiciones para modular la expresion de c90rf72. MX366128B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562148691P 2015-04-16 2015-04-16
US201562232941P 2015-09-25 2015-09-25
US201562239400P 2015-10-09 2015-10-09
PCT/US2016/027747 WO2016168592A2 (en) 2015-04-16 2016-04-15 Compositions for modulating c9orf72 expression

Publications (2)

Publication Number Publication Date
MX2017013199A true MX2017013199A (es) 2018-02-09
MX366128B MX366128B (es) 2019-06-28

Family

ID=57126261

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017013199A MX366128B (es) 2015-04-16 2016-04-15 Composiciones para modular la expresion de c90rf72.
MX2019007834A MX2019007834A (es) 2015-04-16 2017-10-12 Composiciones para modular la expresion de c9orf72.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019007834A MX2019007834A (es) 2015-04-16 2017-10-12 Composiciones para modular la expresion de c9orf72.

Country Status (30)

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US (4) US9605263B2 (es)
EP (2) EP3283080B1 (es)
JP (3) JP6606557B2 (es)
KR (2) KR102104163B1 (es)
CN (2) CN113265404A (es)
AU (2) AU2016249002B2 (es)
BR (1) BR112017016068A2 (es)
CA (1) CA2978103A1 (es)
CL (4) CL2017002567A1 (es)
CO (1) CO2017007671A2 (es)
CY (1) CY1122981T1 (es)
DK (1) DK3283080T3 (es)
ES (1) ES2791995T3 (es)
HK (1) HK1250255A1 (es)
HR (1) HRP20200843T1 (es)
HU (1) HUE049233T2 (es)
IL (2) IL253557B (es)
LT (1) LT3283080T (es)
MX (2) MX366128B (es)
MY (1) MY181815A (es)
NZ (1) NZ733882A (es)
PH (2) PH12017501875B1 (es)
PL (1) PL3283080T3 (es)
PT (1) PT3283080T (es)
RS (1) RS60230B1 (es)
RU (1) RU2736574C2 (es)
SA (3) SA517390168B1 (es)
SG (2) SG10202001856WA (es)
SI (1) SI3283080T1 (es)
WO (1) WO2016168592A2 (es)

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