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MX2017009349A - Celulas inmunitarias geneticamente manipuladas para inactivacion de receptor de cleulas t, dotadas con receptores de antigenos quimericos de union a cd123 para el tratamiento de linfoma mieloide agudo o neoplasia de celulas dendriticas plasmacitoides blasticas recidivante/refractaria. - Google Patents

Celulas inmunitarias geneticamente manipuladas para inactivacion de receptor de cleulas t, dotadas con receptores de antigenos quimericos de union a cd123 para el tratamiento de linfoma mieloide agudo o neoplasia de celulas dendriticas plasmacitoides blasticas recidivante/refractaria.

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Publication number
MX2017009349A
MX2017009349A MX2017009349A MX2017009349A MX2017009349A MX 2017009349 A MX2017009349 A MX 2017009349A MX 2017009349 A MX2017009349 A MX 2017009349A MX 2017009349 A MX2017009349 A MX 2017009349A MX 2017009349 A MX2017009349 A MX 2017009349A
Authority
MX
Mexico
Prior art keywords
immune cells
engineered immune
endowed
chimeric antigen
antigen receptors
Prior art date
Application number
MX2017009349A
Other languages
English (en)
Inventor
Galetto Roman
Duchateau Philippe
Juillerat Alexandre
Johnson Sasu Barbra
Rajpal Arvind
Valton Julien
Simon Mathieu
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2015/055848 external-priority patent/WO2015140268A1/en
Application filed by Cellectis filed Critical Cellectis
Publication of MX2017009349A publication Critical patent/MX2017009349A/es

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Abstract

La presente invención se refiere a células inmunitarias genéticamente manipuladas que expresan un receptor de antígeno quimérico (CAR) específico para CD123 - de inactivación de TCR o de inactivación de TCR y de inactivación de dCK- que es una proteína quimérica recombinante capaz de redirigir la especificidad y reactividad de células inmunitarias hacia las células que expresan CD123, y muy particularmente en las cuales la unión a ligando extracelular es un scFv derivados de un anticuerpo monoclonal de CD123, que confiere inmunidad específica contra las células CD123 positivas. Las células inmunitarias genéticamente manipuladas dotadas de dichos CD123 CARs son particularmente adecuadas para el tratamiento de AML refractaria recidivante y neoplasia de células dendríticas plasmacitoides blásticas y para usarse como un tratamiento antes del trasplante de médula ósea.
MX2017009349A 2015-01-26 2016-01-25 Celulas inmunitarias geneticamente manipuladas para inactivacion de receptor de cleulas t, dotadas con receptores de antigenos quimericos de union a cd123 para el tratamiento de linfoma mieloide agudo o neoplasia de celulas dendriticas plasmacitoides blasticas recidivante/refractaria. MX2017009349A (es)

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PCT/EP2015/055848 WO2015140268A1 (en) 2014-03-19 2015-03-19 Cd123 specific chimeric antigen receptors for cancer immunotherapy
PCT/EP2016/051471 WO2016120220A1 (en) 2015-01-26 2016-01-25 T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to cd123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm

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MX2017009181A MX2017009181A (es) 2015-01-26 2016-01-25 Receptores de antigenos quimericos de cadena sencilla especificos de anti-cll1 para inmunoterapia de cancer.
MX2017009182A MX2017009182A (es) 2015-01-26 2016-01-25 Sistemas de receptor de antigeno quimerico impulsado por mab para clasificar/reducir celulas inmunes diseñadas.

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MX2017009182A MX2017009182A (es) 2015-01-26 2016-01-25 Sistemas de receptor de antigeno quimerico impulsado por mab para clasificar/reducir celulas inmunes diseñadas.

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