MX2016008472A - Anticuero monoclonal neutralizador de anti-il-33-humana. - Google Patents
Anticuero monoclonal neutralizador de anti-il-33-humana.Info
- Publication number
- MX2016008472A MX2016008472A MX2016008472A MX2016008472A MX2016008472A MX 2016008472 A MX2016008472 A MX 2016008472A MX 2016008472 A MX2016008472 A MX 2016008472A MX 2016008472 A MX2016008472 A MX 2016008472A MX 2016008472 A MX2016008472 A MX 2016008472A
- Authority
- MX
- Mexico
- Prior art keywords
- amino acid
- acid sequences
- human anti
- neutralizing monoclonal
- monoclonal antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
El propósito de la presente invención es proporcionar un anticuerpo que muestra una acción antagonista contra IL-33, en particular, un anticuerpo monoclonal neutralizador de anti-IL-33 humana aislado o fragmento del mismo en el cual las secuencias de aminoácidos o regiones de marco son secuencias de aminoácidos de línea germinal o secuencias de aminoácidos de combinaciones de secuencias de aminoácidos de línea germinal. En consecuencia, se identifican epítopos para una pluralidad de anticuerpos monoclonales anti-IL-33, se obtienen anticuerpos monoclonales neutralizadores de anti-IL-33 humana, y se introducen mutaciones en las regiones determinantes de complementariedad de los anticuerpos monoclonales neutralizadores anti-IL-33 humana para especificar una región determinante de complementariedad que muestre alta afinidad a IL-33. La región determinante de complementariedad se utiliza para obtener un anticuerpo monoclonal neutralizador de anti-IL-33 humana en el cual las secuencias de aminoácidos o regiones de marco son secuencias de aminoácidos de línea germinal o secuencias de aminoácidos de combinaciones de secuencias de aminoácidos de línea germinal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013270551 | 2013-12-26 | ||
| JP2014078223 | 2014-04-04 | ||
| PCT/JP2014/084695 WO2015099175A1 (ja) | 2013-12-26 | 2014-12-26 | ヒト抗ｉｌ－３３中和モノクローナル抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016008472A true MX2016008472A (es) | 2016-10-28 |
Family
ID=53479013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008472A MX2016008472A (es) | 2013-12-26 | 2014-12-26 | Anticuero monoclonal neutralizador de anti-il-33-humana. |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9758578B2 (es) |
| EP (2) | EP4223874A3 (es) |
| JP (5) | JP6159419B2 (es) |
| KR (1) | KR102400060B1 (es) |
| CN (2) | CN112079923A (es) |
| AU (1) | AU2014370883B2 (es) |
| BR (1) | BR112016013347B1 (es) |
| CA (2) | CA2934933C (es) |
| DK (1) | DK3088517T5 (es) |
| ES (1) | ES2963673T3 (es) |
| FI (1) | FI3088517T3 (es) |
| HU (1) | HUE064292T2 (es) |
| MX (1) | MX2016008472A (es) |
| PH (1) | PH12016501212B1 (es) |
| PL (1) | PL3088517T3 (es) |
| PT (1) | PT3088517T (es) |
| RU (1) | RU2709722C1 (es) |
| TW (1) | TWI563003B (es) |
| WO (1) | WO2015099175A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| JP6404314B2 (ja) | 2013-03-15 | 2018-10-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｉｌ−３３拮抗薬とその使用法 |
| MX2016008472A (es) * | 2013-12-26 | 2016-10-28 | Mitsubishi Tanabe Pharma Corp | Anticuero monoclonal neutralizador de anti-il-33-humana. |
| SG10201805934RA (en) | 2014-01-10 | 2018-08-30 | Anaptysbio Inc | Antibodies directed against interleukin-33 (il-33) |
| WO2016031932A1 (ja) * | 2014-08-27 | 2016-03-03 | 田辺三菱製薬株式会社 | アルカリ洗浄によるＦｃ領域を有するタンパク質の製造方法 |
| EP3783023A1 (en) | 2014-11-10 | 2021-02-24 | H. Hoffnabb-La Roche Ag | Anti-interleukin-33 antibodies and uses thereof |
| WO2016077366A1 (en) | 2014-11-10 | 2016-05-19 | Genentec, Inc. | Therapeutic and diagnostic methods for il-33-mediated disorders |
| EA201891628A1 (ru) * | 2016-01-14 | 2018-12-28 | Анаптисбайо, Инк. | Ингибирование аллергической реакции с использованием ингибитора il-33 |
| MX2018013038A (es) | 2016-04-27 | 2019-03-28 | Pfizer | Anticuerpos anti-il-33, composiciones, metodos y usos de los mismos. |
| JOP20190093A1 (ar) | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| MX2019009485A (es) | 2017-02-10 | 2019-11-05 | Genentech Inc | Anticuerpos contra triptasa, composiciones de estos y usos de estos. |
| AU2018252974B2 (en) | 2017-04-13 | 2024-10-17 | Regeneron Pharmaceuticals, Inc. | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding IL33 and IL1RL1 |
| MX2020002086A (es) * | 2017-08-31 | 2020-10-28 | Mitsubishi Tanabe Pharma Corp | Agente terapeutico que contiene antagonista de il-33 para endometriosis. |
| CA3088557C (en) | 2018-02-09 | 2024-02-27 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
| IL307286A (en) | 2018-04-11 | 2023-11-01 | Regeneron Pharma | Methods and preparations for quantification of IL-33 |
| EP3851121A4 (en) * | 2018-09-14 | 2022-06-08 | Mitsubishi Tanabe Pharma Corporation | PHARMACEUTICAL COMPOSITION CONTAINING A HUMAN ANTI-IL-33 MONOCLONAL ANTIBODY |
| EP4055044A1 (en) | 2019-11-04 | 2022-09-14 | MedImmune Limited | Anti il-33 therapeutic agent for treating renal disorders |
| US20220380450A1 (en) | 2019-11-04 | 2022-12-01 | Medimmune Limited | Methods of using il-33 antagonists |
| US20230110203A1 (en) | 2020-03-13 | 2023-04-13 | Medimmune Limited | Therapeutic methods for the treatment of subjects with risk alelles in il33 |
| EP4118114A1 (en) | 2020-03-13 | 2023-01-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| US20230174637A1 (en) | 2020-04-06 | 2023-06-08 | Medimmune Limited | Treating acute respiratory distress syndrome with il-33 axis binding antagonists |
| CA3181765A1 (en) | 2020-05-11 | 2021-11-18 | Medimmune Limited | Formulations of anti-il-33 antibodies |
| CN111378037B (zh) * | 2020-06-01 | 2020-09-01 | 南京诺艾新生物技术有限公司 | 一种抗hIL-33人源化单抗及其应用 |
| CN111620948B (zh) * | 2020-06-10 | 2022-04-08 | 南京赛新生物科技有限公司 | 针对il-33的抗体 |
| KR20220022226A (ko) * | 2020-08-18 | 2022-02-25 | 성균관대학교산학협력단 | Il-33 항체 또는 이의 항원 결합 단편 |
| CN114249825A (zh) * | 2020-09-25 | 2022-03-29 | 三生国健药业（上海）股份有限公司 | 结合人il-33的抗体、其制备方法和用途 |
| CA3203805A1 (en) | 2021-01-08 | 2022-07-14 | Cellanome, Inc. | Devices and methods for analyzing biological samples |
| CN113493513B (zh) * | 2021-06-30 | 2022-07-12 | 深圳大学 | 抗人il-33中和性自身抗体及其制备方法和应用 |
| CN113912728B (zh) * | 2021-11-04 | 2023-08-29 | 江苏荃信生物医药股份有限公司 | 降低抗人白介素-33单克隆抗体生产中宿主细胞蛋白含量的亲和纯化方法 |
| CN114014929B (zh) * | 2021-11-04 | 2022-07-19 | 江苏荃信生物医药股份有限公司 | 一种抗人白介素-33单克隆抗体浓缩溶液的制备方法 |
| WO2023086807A1 (en) | 2021-11-10 | 2023-05-19 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| TW202402790A (zh) | 2022-03-25 | 2024-01-16 | 英商梅迪繆思有限公司 | 減少呼吸系統感染之方法 |
| WO2024038185A1 (en) | 2022-08-19 | 2024-02-22 | Medimmune Limited | Method of selecting patients for treatment with an il-33 axis antagonist |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| JPH021556A (ja) | 1988-06-09 | 1990-01-05 | Snow Brand Milk Prod Co Ltd | ハイブリッド抗体及びその作製方法 |
| TW205553B (es) | 1991-04-25 | 1993-05-11 | Chugai Pharmaceutical Co Ltd | |
| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| KR20140094647A (ko) | 1999-03-25 | 2014-07-30 | 아비에 도이치란트 게엠베하 운트 콤파니 카게 | 사람 ｉｌ-12에 결합하는 사람 항체 및 이의 제조방법 |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| DK2314686T4 (da) | 2000-10-06 | 2023-08-21 | Kyowa Kirin Co Ltd | Celler, der danner antistofsammensætninger |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| US20080241884A1 (en) | 2003-10-08 | 2008-10-02 | Kenya Shitara | Fused Protein Composition |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| ATE492563T1 (de) | 2004-11-17 | 2011-01-15 | Amgen Inc | Vollständige humane monoklonale antikörper gegen il-13 |
| KR101340559B1 (ko) * | 2005-06-01 | 2013-12-11 | 암젠 리서치 (뮌헨) 게엠베하 | 항-인터루킨2 항체 |
| PL2314623T3 (pl) | 2005-06-21 | 2012-11-30 | Xoma Us Llc | Przeciwciała wiążące il-1 beta i ich fragmenty |
| PE20071101A1 (es) * | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| EP3415532A1 (en) * | 2006-08-18 | 2018-12-19 | XOMA Technology Ltd. | Prlr-specific antibody and uses thereof |
| IN2009KN02404A (es) | 2006-12-14 | 2015-08-07 | Medarex Inc | |
| CA2685124A1 (en) * | 2007-04-26 | 2008-11-06 | Provost, Fellows And Scholars Of The College Of The Holy And Undivided T Rinity Of Queen Elizabeth Near Dublin | Products for altering il-33 activity and methods therefor |
| AU2008254704A1 (en) * | 2007-05-18 | 2008-11-27 | Medimmune, Llc | IL-33 in inflammatory disease |
| WO2010000721A1 (en) | 2008-06-30 | 2010-01-07 | Novo Nordisk A/S | Anti-human interleukin-20 antibodies |
| WO2010032061A1 (en) | 2008-09-19 | 2010-03-25 | Medimmune Llc | Antibodies against sonic hedgehog homolog and uses thereof |
| WO2011031600A1 (en) | 2009-09-10 | 2011-03-17 | Schering Corporation | Use of il-33 antagonists to treat fibrotic disease |
| US8926976B2 (en) * | 2009-09-25 | 2015-01-06 | Xoma Technology Ltd. | Modulators |
| US20130011406A1 (en) * | 2010-03-26 | 2013-01-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| FR2972006B1 (fr) | 2011-02-24 | 2016-03-25 | Centre Nat Rech Scient | Nouveaux fragments d'il-33 superactifs et leurs utilisations |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| JP6404314B2 (ja) | 2013-03-15 | 2018-10-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｉｌ−３３拮抗薬とその使用法 |
| MX2016008472A (es) * | 2013-12-26 | 2016-10-28 | Mitsubishi Tanabe Pharma Corp | Anticuero monoclonal neutralizador de anti-il-33-humana. |
| SG10201805934RA (en) | 2014-01-10 | 2018-08-30 | Anaptysbio Inc | Antibodies directed against interleukin-33 (il-33) |
| WO2016031932A1 (ja) * | 2014-08-27 | 2016-03-03 | 田辺三菱製薬株式会社 | アルカリ洗浄によるＦｃ領域を有するタンパク質の製造方法 |
| WO2016077366A1 (en) | 2014-11-10 | 2016-05-19 | Genentec, Inc. | Therapeutic and diagnostic methods for il-33-mediated disorders |
| US10500273B2 (en) | 2015-03-02 | 2019-12-10 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using an IL-33 antagonist |
| MX2017012616A (es) | 2015-03-31 | 2018-04-10 | Medimmune Ltd | Nueva forma de interleucina-33 (il33), formas mutadas de interleucina-33 (il33), anticuerpos, ensayos y metodos para usar los mismos. |
| JP6501650B2 (ja) | 2015-06-25 | 2019-04-17 | 田辺三菱製薬株式会社 | ヒト抗ｉｌ−３３中和モノクローナル抗体 |
| CN108137682A (zh) | 2015-10-06 | 2018-06-08 | 瑞泽恩制药公司 | 与白介素-33(il-33)介导的疾病有关的生物标志物及其用途 |
| KR102589598B1 (ko) | 2017-03-01 | 2023-10-13 | 메디뮨 리미티드 | 단클론 항체의 제형 |
| MX2020002086A (es) | 2017-08-31 | 2020-10-28 | Mitsubishi Tanabe Pharma Corp | Agente terapeutico que contiene antagonista de il-33 para endometriosis. |
| EP3851121A4 (en) | 2018-09-14 | 2022-06-08 | Mitsubishi Tanabe Pharma Corporation | PHARMACEUTICAL COMPOSITION CONTAINING A HUMAN ANTI-IL-33 MONOCLONAL ANTIBODY |
-
2014
- 2014-12-26 MX MX2016008472A patent/MX2016008472A/es unknown
- 2014-12-26 CA CA2934933A patent/CA2934933C/en active Active
- 2014-12-26 CA CA3190793A patent/CA3190793A1/en active Pending
- 2014-12-26 TW TW103145768A patent/TWI563003B/zh active
- 2014-12-26 DK DK14873812.3T patent/DK3088517T5/da active
- 2014-12-26 PL PL14873812.3T patent/PL3088517T3/pl unknown
- 2014-12-26 PT PT148738123T patent/PT3088517T/pt unknown
- 2014-12-26 US US15/037,998 patent/US9758578B2/en active Active
- 2014-12-26 EP EP23166641.3A patent/EP4223874A3/en active Pending
- 2014-12-26 RU RU2016125489A patent/RU2709722C1/ru active
- 2014-12-26 EP EP14873812.3A patent/EP3088517B1/en active Active
- 2014-12-26 BR BR112016013347-1A patent/BR112016013347B1/pt active IP Right Grant
- 2014-12-26 FI FIEP14873812.3T patent/FI3088517T3/fi active
- 2014-12-26 HU HUE14873812A patent/HUE064292T2/hu unknown
- 2014-12-26 KR KR1020167017081A patent/KR102400060B1/ko active IP Right Grant
- 2014-12-26 JP JP2015555074A patent/JP6159419B2/ja active Active
- 2014-12-26 CN CN202010976343.7A patent/CN112079923A/zh active Pending
- 2014-12-26 ES ES14873812T patent/ES2963673T3/es active Active
- 2014-12-26 AU AU2014370883A patent/AU2014370883B2/en active Active
- 2014-12-26 CN CN201480071117.7A patent/CN105980556B/zh active Active
- 2014-12-26 WO PCT/JP2014/084695 patent/WO2015099175A1/ja active Application Filing
-
2016
- 2016-06-21 PH PH12016501212A patent/PH12016501212B1/en unknown
-
2017
- 2017-06-09 JP JP2017114387A patent/JP6548696B2/ja active Active
- 2017-06-13 US US15/621,950 patent/US20170283494A1/en not_active Abandoned
-
2019
- 2019-03-04 JP JP2019039078A patent/JP2019142865A/ja active Pending
- 2019-05-16 US US16/414,602 patent/US11725049B2/en active Active
-
2020
- 2020-12-28 JP JP2020219204A patent/JP2021054855A/ja active Pending
-
2022
- 2022-10-25 JP JP2022170759A patent/JP2022191486A/ja active Pending
-
2023
- 2023-06-23 US US18/340,790 patent/US20240002495A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12016501212A1 (en) | Human anti-il-33 neutralizing monoclonal antibody | |
| PH12018502225A1 (en) | Anti-il-33 antibodies, compositions, methods and uses thereof | |
| EA201690167A1 (ru) | Гуманизованные или химерные антитела к cd3 | |
| EA201890305A1 (ru) | Гуманизированные или химерные cd3-антитела | |
| PH12017500819A1 (en) | Cd3/cd38 t cell retargeting hetero-dimeric immunoglobulins and methods of their production | |
| EA201890383A8 (ru) | Конструкции биспецифических антител, связывающиеся с мезотелином и кд3 (cd3) | |
| MX2016005765A (es) | Anticuerpos anti-il-17, un metodo para producir y utilizar los mismos. | |
| EA201792467A1 (ru) | Гетеродимерные антитела, которые связывают cd3 и опухолевые антигены | |
| EA201792221A1 (ru) | Антитела против сортилина и способы их применения | |
| ZA201701920B (en) | Anti-human il-17 monoclonal antibodies and use thereof | |
| EA201692394A1 (ru) | Антитела и антигенсвязывающие фрагменты, которые специфично связываются с белком тау, ассоциированным с микротрубочками | |
| EA201791029A1 (ru) | Антитела против интерлейкина-33 и их применение | |
| UA116873C2 (uk) | Антитіло, яке зв'язується з ox40 | |
| EA201591091A1 (ru) | Антигенсвязывающие белки для bcma | |
| EP3294766C0 (en) | HUMANIZED ANTIBODY OR FRAGMENT THEREOF SPECIFIC FOR CD3 | |
| EA201891709A1 (ru) | Антигенсвязывающие белки, связывающие pd-l1 | |
| EA201400875A1 (ru) | Антитела к cd47 и способы их применения | |
| NZ711451A (en) | Anti-c5 antibodies having improved pharmacokinetics | |
| MX2016007208A (es) | Anticuerpos anti-tau(ps422) humanizados y metodos de uso. | |
| EA202091315A2 (ru) | Антитела человека, связывающиеся с g-белком rsv | |
| MY184189A (en) | Methods of treating nail and scalp psoriasis | |
| PH12015501632A1 (en) | Humanized anti-hmgbi antibody or antigen-binding fragment thereof | |
| NZ730186A (en) | Humanized anti-hepcidin antibodies and uses thereof | |
| PH12016501579B1 (en) | Novel anti-presepsin antibody | |
| EA201892313A1 (ru) | Гуманизированные антитела против clever-1 и их применение |