MX2015015225A - Suministro de inmunosupresores que tienen una vida efectiva especificada, farmacodinámica especificada y antígeno para la inducción de tolerancia inmunitaria. - Google Patents
Suministro de inmunosupresores que tienen una vida efectiva especificada, farmacodinámica especificada y antígeno para la inducción de tolerancia inmunitaria.Info
- Publication number
- MX2015015225A MX2015015225A MX2015015225A MX2015015225A MX2015015225A MX 2015015225 A MX2015015225 A MX 2015015225A MX 2015015225 A MX2015015225 A MX 2015015225A MX 2015015225 A MX2015015225 A MX 2015015225A MX 2015015225 A MX2015015225 A MX 2015015225A
- Authority
- MX
- Mexico
- Prior art keywords
- immunosuppressants
- inducation
- antigen
- delivery
- life
- Prior art date
Links
- 229960003444 immunosuppressant agent Drugs 0.000 title abstract 3
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 3
- 230000006058 immune tolerance Effects 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 230000003285 pharmacodynamic effect Effects 0.000 title 1
- 229920002521 macromolecule Polymers 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 2
- 230000003614 tolerogenic effect Effects 0.000 abstract 1
Classifications
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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Abstract
Esta invención se refiere a métodos que proporcionan inmunosupresores y macromoléculas terapéuticas que se administran dentro de una ventana farmacodinámicamente efectiva de los inmunosupresores para inducir tolerancia inmunitaria a las macromoléculas terapéuticas; los métodos permiten el movimiento de la respuesta inmunitaria a favor del desarrollo de respuesta inmunitaria tolerogénica específico para la macromolécula terapéutica.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
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US201361819517P | 2013-05-03 | 2013-05-03 | |
US201361881921P | 2013-09-24 | 2013-09-24 | |
US201361881851P | 2013-09-24 | 2013-09-24 | |
US201361881913P | 2013-09-24 | 2013-09-24 | |
US201361907177P | 2013-11-21 | 2013-11-21 | |
US201461948384P | 2014-03-05 | 2014-03-05 | |
US201461948313P | 2014-03-05 | 2014-03-05 | |
PCT/US2014/036697 WO2014179770A1 (en) | 2013-05-03 | 2014-05-02 | Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the inducation of immune tolerance |
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MX2015015225A MX2015015225A (es) | 2013-05-03 | 2014-05-02 | Suministro de inmunosupresores que tienen una vida efectiva especificada, farmacodinámica especificada y antígeno para la inducción de tolerancia inmunitaria. |
MX2015015223A MX2015015223A (es) | 2013-05-03 | 2014-05-02 | Administración local y concomitante de nanoportadores sintéticos, tolerogénicos para reducir la hipersensibilidad tipo i y tipo iv. |
MX2015015221A MX2015015221A (es) | 2013-05-03 | 2014-05-02 | Nanoportadores sintéticos tolerogénicos y macromoléculas terapéuticas para efectos farmacodinámicos reducidos o intensificados. |
MX2021005697A MX2021005697A (es) | 2013-05-03 | 2014-05-02 | Suministro de inmunosupresores que tienen una vida efectiva especificada, farmacodinamica y antigeno para la induccion de tolerancia inmunitaria. |
MX2015015231A MX2015015231A (es) | 2013-05-03 | 2014-05-02 | Métodos y composiciones para mejorar las células t reguladoras de cd4+. |
MX2015015230A MX2015015230A (es) | 2013-05-03 | 2014-05-02 | Nanoportadores sintéticos tolerogénicos para reducir o prevenir anafilaxia en respuesta a un antígeno no alergénico. |
MX2021001878A MX2021001878A (es) | 2013-05-03 | 2015-10-30 | Metodos y composiciones para mejorar las celulas t reguladoras cd4+. |
MX2021001879A MX2021001879A (es) | 2013-05-03 | 2015-10-30 | Combinaciones de dosificaciones para reducir las respuestas inmunes humorales no deseadas. |
MX2021001982A MX2021001982A (es) | 2013-05-03 | 2015-10-30 | Administracion local y concomitante de nanoportadores sinteticos, tolerogenicos para reducir la hipersensibilidad tipo i y tipo iv. |
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MX2022009538A MX2022009538A (es) | 2013-05-03 | 2015-10-30 | Nanoportadores sinteticos tolerogenicos y macromoleculas terapeuticas para efectos farmacodinamicos reducidos o intensificados. |
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MX2015015223A MX2015015223A (es) | 2013-05-03 | 2014-05-02 | Administración local y concomitante de nanoportadores sintéticos, tolerogénicos para reducir la hipersensibilidad tipo i y tipo iv. |
MX2015015221A MX2015015221A (es) | 2013-05-03 | 2014-05-02 | Nanoportadores sintéticos tolerogénicos y macromoléculas terapéuticas para efectos farmacodinámicos reducidos o intensificados. |
MX2021005697A MX2021005697A (es) | 2013-05-03 | 2014-05-02 | Suministro de inmunosupresores que tienen una vida efectiva especificada, farmacodinamica y antigeno para la induccion de tolerancia inmunitaria. |
MX2015015231A MX2015015231A (es) | 2013-05-03 | 2014-05-02 | Métodos y composiciones para mejorar las células t reguladoras de cd4+. |
MX2015015230A MX2015015230A (es) | 2013-05-03 | 2014-05-02 | Nanoportadores sintéticos tolerogénicos para reducir o prevenir anafilaxia en respuesta a un antígeno no alergénico. |
MX2021001878A MX2021001878A (es) | 2013-05-03 | 2015-10-30 | Metodos y composiciones para mejorar las celulas t reguladoras cd4+. |
MX2021001879A MX2021001879A (es) | 2013-05-03 | 2015-10-30 | Combinaciones de dosificaciones para reducir las respuestas inmunes humorales no deseadas. |
MX2021001982A MX2021001982A (es) | 2013-05-03 | 2015-10-30 | Administracion local y concomitante de nanoportadores sinteticos, tolerogenicos para reducir la hipersensibilidad tipo i y tipo iv. |
MX2021012348A MX2021012348A (es) | 2013-05-03 | 2015-10-30 | Nanoportadores sinteticos tolerogenicos para reducir o prevenir anafilaxia en respuesta a un antigeno no alergenico. |
MX2022009538A MX2022009538A (es) | 2013-05-03 | 2015-10-30 | Nanoportadores sinteticos tolerogenicos y macromoleculas terapeuticas para efectos farmacodinamicos reducidos o intensificados. |
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EP (7) | EP2991630A4 (es) |
JP (18) | JP6818549B2 (es) |
KR (18) | KR20160003215A (es) |
CN (17) | CN111068061A (es) |
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DK (1) | DK2991646T3 (es) |
EA (6) | EA201592106A3 (es) |
ES (1) | ES2842206T3 (es) |
HU (1) | HUE052599T2 (es) |
IL (14) | IL284732B2 (es) |
MX (12) | MX2015015229A (es) |
WO (5) | WO2014179769A2 (es) |
Families Citing this family (31)
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EP2435094A2 (en) | 2009-05-27 | 2012-04-04 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
BR112012029912A2 (pt) | 2010-05-26 | 2016-11-16 | Selecta Biosciences Inc | vácinas de combinação de nanotransportadores sintéticos |
EP2640190A4 (en) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | MODIFIED NICOTINIC COMPOUNDS AND ASSOCIATED METHODS |
EP2701705A4 (en) | 2011-04-29 | 2015-01-28 | Selecta Biosciences Inc | SYNTHETIC TOLEROGENIC NANOTRÄGER FOR REDUCING IMMUNE RESPONSES TO THERAPEUTIC PROTEINS |
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