MX2008014692A - Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno. - Google Patents
Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno.Info
- Publication number
- MX2008014692A MX2008014692A MX2008014692A MX2008014692A MX2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen
- cells
- obtaining
- specific
- culture method
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000012136 culture method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80141206P | 2006-05-19 | 2006-05-19 | |
PCT/US2007/011980 WO2008045140A1 (fr) | 2006-05-19 | 2007-05-21 | Procédé de culture permettant d'obtenir une population clonée de lymphocytes b spécifiques d'antigène |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008014692A true MX2008014692A (es) | 2009-08-18 |
Family
ID=39283142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008014692A MX2008014692A (es) | 2006-05-19 | 2007-05-21 | Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno. |
Country Status (12)
Country | Link |
---|---|
US (3) | US20070269868A1 (fr) |
EP (1) | EP2021463B1 (fr) |
JP (1) | JP5607357B2 (fr) |
CN (1) | CN101600793B (fr) |
AU (1) | AU2007307324B2 (fr) |
CA (1) | CA2652392C (fr) |
DK (1) | DK2021463T3 (fr) |
IL (1) | IL195285A (fr) |
MX (1) | MX2008014692A (fr) |
NO (1) | NO20084835L (fr) |
NZ (1) | NZ572807A (fr) |
WO (1) | WO2008045140A1 (fr) |
Families Citing this family (66)
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US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
LT2164514T (lt) | 2007-05-21 | 2017-03-10 | Alderbio Holdings Llc | Il-6 antikūnai ir jų naudojimas |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
KR20110091781A (ko) * | 2008-11-25 | 2011-08-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 혈전증을 예방하거나 치료하기 위한 il6의 길항제 |
US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
EP2473531A4 (fr) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anticorps anti-gitr |
US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
AU2010324739B2 (en) | 2009-11-24 | 2016-05-05 | H. Lundbeck A/S. | Antibodies to IL-6 and use thereof |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
TWI667257B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
PL2400298T3 (pl) * | 2010-05-28 | 2014-01-31 | Hoffmann La Roche | Sposób hodowania pojedynczych komórek b oraz wytwarzania swoistych przeciwciał |
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EP2646468B1 (fr) | 2010-12-01 | 2018-07-25 | AlderBio Holdings LLC | Compositions anti-ngf et leur utilisation |
KR20140032394A (ko) * | 2011-03-30 | 2014-03-14 | 내셔날 유니버시티 코포레이션 유니버시티 오브 토야마 | 형질 세포 또는 형질아 세포의 선택 방법, 목적 항원 특이적인 항체의 제조 방법, 신규 단일 클론 항체 |
WO2012162243A2 (fr) | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Compositions comprenant des anticorps anti-cgrp et leur utilisation |
EP2709662B1 (fr) | 2011-05-20 | 2019-07-31 | AlderBio Holdings LLC | Utilisation d'anticorps ou de fragments d'anticorps anti-cgrp ou anti-cgrp-r dans le traitement ou la prévention de formes chroniques et aiguës de la diarrhée |
US9708393B2 (en) | 2011-05-20 | 2017-07-18 | Alderbio Holdings Llc | Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
EP2724157B1 (fr) * | 2011-06-27 | 2017-03-08 | Valneva | Procédé de criblage de cellules |
CN103987853A (zh) * | 2011-09-28 | 2014-08-13 | Cb生物技术公司 | 使用Arm-PCR和高通量测序鉴定抗原特异的适应性免疫应答 |
KR102069394B1 (ko) | 2011-11-23 | 2020-01-22 | 에프. 호프만-라 로슈 아게 | Cd40l 발현 포유류 세포 및 그의 용도 |
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EP2727941A1 (fr) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Procédé pour la production d'anticorps multispécifiques |
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CN104232577B (zh) * | 2013-06-20 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种获得自身反应性b细胞的方法 |
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EP3960765A1 (fr) | 2015-06-26 | 2022-03-02 | Sanofi Biotechnology SAS | Anticorps monoclonaux anti-il-1racp |
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EP3241845A1 (fr) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Anticorps anti-il-1r3 humanisés |
CN106350485B (zh) * | 2016-08-24 | 2020-02-21 | 杭州百凌生物科技有限公司 | 一种快速高效分离单个抗原特异性b细胞的方法 |
JP6916884B2 (ja) | 2017-01-02 | 2021-08-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B細胞培養法 |
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CN110621773B (zh) | 2017-05-19 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 用于产生胸腺细胞上清液的方法 |
US11125757B2 (en) * | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
WO2019105864A1 (fr) | 2017-11-30 | 2019-06-06 | F. Hoffmann-La Roche Ag | Procédé de culture de lymphocytes b |
JP2021525070A (ja) * | 2018-05-18 | 2021-09-24 | チャン ザッカーバーグ バイオハブ, インコーポレイテッド | ヒト由来のアレルゲン特異的抗体を単離する方法およびその使用 |
JP2022542863A (ja) | 2019-07-24 | 2022-10-07 | ハー・ルンドベック・アクチエゼルスカベット | 抗mGluR5抗体及びその使用 |
JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
WO2022004620A1 (fr) * | 2020-06-29 | 2022-01-06 | 株式会社Npt | Procédé de fabrication d'une composition comprenant des cellules productrices d'anticorps spécifiques d'un antigène, procédé de fabrication d'une composition vaccinale, kit de séparation de cellules et composition vaccinale |
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TW202428613A (zh) | 2022-09-21 | 2024-07-16 | 法商賽諾菲生物技術公司 | 人源化抗il-1r3抗體及使用方法 |
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US6657103B1 (en) * | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
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US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
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-
2007
- 2007-05-21 CA CA2652392A patent/CA2652392C/fr not_active Expired - Fee Related
- 2007-05-21 CN CN200780027028.2A patent/CN101600793B/zh not_active Expired - Fee Related
- 2007-05-21 AU AU2007307324A patent/AU2007307324B2/en not_active Ceased
- 2007-05-21 US US11/802,235 patent/US20070269868A1/en not_active Abandoned
- 2007-05-21 EP EP07861311.4A patent/EP2021463B1/fr not_active Revoked
- 2007-05-21 MX MX2008014692A patent/MX2008014692A/es active IP Right Grant
- 2007-05-21 NZ NZ572807A patent/NZ572807A/en not_active IP Right Cessation
- 2007-05-21 DK DK07861311.4T patent/DK2021463T3/en active
- 2007-05-21 WO PCT/US2007/011980 patent/WO2008045140A1/fr active Application Filing
- 2007-05-21 JP JP2009512060A patent/JP5607357B2/ja not_active Expired - Fee Related
-
2008
- 2008-11-13 IL IL195285A patent/IL195285A/en active IP Right Grant
- 2008-11-18 NO NO20084835A patent/NO20084835L/no unknown
-
2011
- 2011-08-08 US US13/204,915 patent/US20120141982A1/en not_active Abandoned
-
2013
- 2013-04-12 US US13/861,518 patent/US20130316353A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20130316353A1 (en) | 2013-11-28 |
CN101600793A (zh) | 2009-12-09 |
JP2009537176A (ja) | 2009-10-29 |
WO2008045140A1 (fr) | 2008-04-17 |
DK2021463T3 (en) | 2017-01-16 |
CN101600793B (zh) | 2013-06-26 |
US20120141982A1 (en) | 2012-06-07 |
EP2021463A4 (fr) | 2009-09-02 |
EP2021463B1 (fr) | 2016-11-23 |
AU2007307324A1 (en) | 2008-04-17 |
IL195285A0 (en) | 2011-08-01 |
JP5607357B2 (ja) | 2014-10-15 |
CA2652392C (fr) | 2017-10-10 |
CA2652392A1 (fr) | 2008-04-17 |
AU2007307324B2 (en) | 2013-08-15 |
EP2021463A1 (fr) | 2009-02-11 |
NO20084835L (no) | 2009-02-16 |
IL195285A (en) | 2012-07-31 |
NZ572807A (en) | 2011-10-28 |
US20070269868A1 (en) | 2007-11-22 |
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