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MA42164B1 - Composes biheteroaryle et leurs utilisations - Google Patents

Composes biheteroaryle et leurs utilisations

Info

Publication number
MA42164B1
MA42164B1 MA42164A MA42164A MA42164B1 MA 42164 B1 MA42164 B1 MA 42164B1 MA 42164 A MA42164 A MA 42164A MA 42164 A MA42164 A MA 42164A MA 42164 B1 MA42164 B1 MA 42164B1
Authority
MA
Morocco
Prior art keywords
biheteroaryl compounds
formula
compounds
biheteroaryl
diseases
Prior art date
Application number
MA42164A
Other languages
English (en)
Other versions
MA42164A1 (fr
Inventor
Kevin X Chen
Liting Dong
Anthony Estrada
Paul Gibbons
Malcolm Huestis
Terry Kellar
Wen Liu
Joseph P Lyssikatos
Changyou Ma
Alan Olivero
Snahel Patel
Daniel Shore
Michael Siu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA42164A1 publication Critical patent/MA42164A1/fr
Publication of MA42164B1 publication Critical patent/MA42164B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract

La présente invention concerne des composés représentés par la formule i-i ainsi que des modes de réalisation et des sels correspondants qui sont destinés au traitement de maladies (notamment, de maladies neurodégénératives). R 1, r 2, r 3, x 1, x 2, a et la variable cy de la formule i-i possèdent tous la signification telle que définie dans la description.
MA42164A 2013-05-01 2014-04-30 Composes biheteroaryle et leurs utilisations MA42164B1 (fr)

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