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Bayer et al., 2021 - Google Patents

Model transferability and reduced experimental burden in cell culture process development facilitated by hybrid modeling and intensified design of experiments

Bayer et al., 2021

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Document ID
3081125721984924213
Author
Bayer B
Duerkop M
Striedner G
Sissolak B
Publication year
Publication venue
Frontiers in Bioengineering and Biotechnology

External Links

Snippet

Reliable process development is accompanied by intense experimental effort. The utilization of an intensified design of experiments (iDoE)(intra-experimental critical process parameter (CPP) shifts combined) with hybrid modeling potentially reduces process development …
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

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