Martin et al., 2017 - Google Patents
Molecular genetics of penicillin and cephalosporin antibiotic biosynthesisMartin et al., 2017
- Document ID
- 10587523978104335207
- Author
- Martin J
- Ingolia T
- Queener S
- Publication year
- Publication venue
- Molecular industrial mycology
External Links
Snippet
Application of molecular genetics to antibiotic biosynthesis and production in microorganisms has increased rapidly in the last few years (Martin and Gil, 1982; Hopwood and Chater, 1984; Ingolia and Queener, 1989; Miller and Ingolia, 1989) but is still in the …
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 N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 0 title abstract description 87
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/104—Aminoacyltransferases (2.3.2)
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
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- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01005—Tyrosine transaminase (2.6.1.5)
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