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Wu et al., 2012 - Google Patents

Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation

Wu et al., 2012

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Document ID
4238752933285559313
Author
Wu X
García-Estrada C
Vaca I
Martín J
Publication year
Publication venue
Biochimie

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The first step in the penicillin biosynthetic pathway is the non-ribosomal condensation of l-α- aminoadipic acid, l-cysteine and l-valine into the tripeptide δ-(l-α-aminoadipyl)-l-cysteinyl-d- valine (ACV). This reaction is catalysed by the multienzyme ACV synthetase (ACVS), which …
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