Nothing Special   »   [go: up one dir, main page]

Deshmukh et al., 2015 - Google Patents

Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy

Deshmukh et al., 2015

View HTML @Full View
Document ID
7499378719483823319
Author
Deshmukh L
Ghirlando R
Clore G
Publication year
Publication venue
Proceedings of the National Academy of Sciences

External Links

Snippet

Assembly and maturation of the human immunodeficiency virus type 1 (HIV-1) are governed by the Gag polyprotein. Here we study the conformation and dynamics of a large HIV-1 Gag fragment comprising the matrix, capsid, spacer peptide 1 and nucleocapsid domains …
Continue reading at www.pnas.org (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING; COUNTING
    • G06F—ELECTRICAL DIGITAL DATA PROCESSING
    • G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
    • G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
    • G06F19/16—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for molecular structure, e.g. structure alignment, structural or functional relations, protein folding, domain topologies, drug targeting using structure data, involving two-dimensional or three-dimensional structures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries

Similar Documents

Publication Publication Date Title
Deshmukh et al. Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy
Bharat et al. Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly
Beaulieu et al. Structural and biophysical insights into the function of the intrinsically disordered Myc oncoprotein
Wolfe et al. Machine learning to predict cell-penetrating peptides for antisense delivery
Crowe et al. Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction
Eckert et al. Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region
Lorieau et al. The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid: water interface
Huang et al. Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer
Zandarashvili et al. Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble
Miao et al. M2 Proton Channel Structural Validation from Full Length Protein Samples in Synthetic Bilayers and E. coli Membranes
Pervushin et al. Structure and inhibition of the SARS coronavirus envelope protein ion channel
Vaynberg et al. Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility
Wu et al. Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking
Elias et al. Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids
Slavin et al. Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2
Sajid et al. Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
Barozzi et al. Affibody-binding ligands
Deshmukh et al. Transient HIV-1 Gag–protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations
Spiliotopoulos et al. Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11
Bie et al. Insights into the binding mode of AS1411 aptamer to nucleolin
De Paula et al. Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles
Vlach et al. D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein
Yang et al. Macrocyclic peptides uncover a novel binding mode for reversible inhibitors of LSD1
Bodor et al. DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity
Deshmukh et al. Investigation of the Structure and Dynamics of the Capsid–Spacer Peptide 1–Nucleocapsid Fragment of the HIV‐1 Gag Polyprotein by Solution NMR Spectroscopy