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Steppeler et al., 2021 - Google Patents

Synthesis of terminal alkynes based on (1S, 3R, 4R)-and (1S, 3S, 4R)-2-azabicyclo [2.2. 1] heptane

Steppeler et al., 2021

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Document ID
4102802497135790117
Author
Steppeler F
Górecki M
Wojaczyńska E
Publication year
Publication venue
Organic Chemistry

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Two approaches to terminal alkynes based on the enantiomerically pure epimers (1S, 3R, 4R)-and (1S, 3S, 4R)-2-azabicyclo [2.2. 1] heptane aldehydes were established: i) a non- Wittig route through a dichloroalkene intermediate; and, ii) a Corey-Fuchs approach via …
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    • C07F7/1848—C1 being an unsubstituted acyclic saturated hydrocarbon radical containing less than six carbon atoms, a benzyl radical, a phenyl radical, or a methyl substituted phenyl radical
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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