" ... Based on a large body of experimental recordings from both the soma and dendrites of L5b pyramidal cells in adult rats, we characterized key features of the somatic and dendritic firing and quantified their statistics. We used these features to constrain the density of a set of ion channels over the soma and dendritic surface via multi-objective optimization with an evolutionary algorithm, thus generating a set of detailed conductance-based models that faithfully replicate the back-propagating action potential activated Ca(2+) spike firing and the perisomatic firing response to current steps, as well as the experimental variability of the properties. Furthermore, we show a useful way to analyze model parameters with our sets of models, which enabled us to identify some of the mechanisms responsible for the dynamic properties of L5b pyramidal cells as well as mechanisms that are sensitive to morphological changes. ..."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: Na/Ca exchanger; Na/K pump; I Sodium

Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Reaction-diffusion; Synaptic Plasticity; Active Dendrites; Olfaction

Simulation Environment: NEURON

Implementer(s): Zylbertal, Asaph [asaph.zylbertal at mail.huji.ac.il]

References:

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

Zylbertal A, Yarom Y, Wagner S. (2017). The Slow Dynamics of Intracellular Sodium Concentration Increase the Time Window of Neuronal Integration: A Simulation Study Frontiers in computational neuroscience. 11 [PubMed]