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Open AccessAMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity
Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reve...
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Open AccessComprehensive genomic analysis and evaluation of in vivo and in vitro safety of Heyndrickxia coagulans BC99
This study aimed to evaluate the safety profile and beneficial effects of Heyndrickxia coagulans strain BC99 (BC99) for potential use in functional foods and pharmaceuticals. We began with whole genome sequencing...
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Open AccessRemission rate, toxicity and pharmacokinetics of venetoclax-based induction regimens in untreated pediatric acute myeloid leukemia
The efficacy and safety of venetoclax in newly diagnosed pediatric acute myeloid leukemia (AML) are not well-established as they are in adults. Children newly diagnosed with AML were recommended for induction ...
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Investigation of infections status in pediatric patients with acute myeloid leukemia during the induction period–a retrospective study in two medical centers
This study aims to investigate the clinical characteristics of infections following induction chemotherapy for acute myeloid leukemia (AML) in children and identify risk factors associated with severe infectio...
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Integration of Transcriptome and Metabolome Provides Key Genes and Pathways Associated with Cold Stress in Watermelon (Citrullus lanatus)
Cold stress is a significant abiotic factor limiting watermelon growth. In this study, we evaluated the impact of cold stress on watermelon development using physiological, transcriptomic, and metabolic data. ...
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Open AccessN-glycosylation of the envelope glycoprotein I is essential for the proliferation and virulence of the duck plague virus
Duck plague virus (DPV) causes the highly pathogenic duck plague, and the envelope glycoprotein I (gI), as one of the key virulence genes, has not yet had its critical virulence sites identified through screen...
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Open AccessDiversity and distribution of a prevalent Microviridae group across the global oceans
Small single-stranded DNA phages of the Microviridae family are diverse and prevalent in oceans. Our understanding of Microviridae phages that infect the ecologically important marine Roseobacter is currently lim...
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Open AccessSTASCAN deciphers fine-resolution cell distribution maps in spatial transcriptomics by deep learning
Spatial transcriptomics technologies have been widely applied to decode cellular distribution by resolving gene expression profiles in tissue. However, sequencing techniques still limit the ability to create a...
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Open AccessBandgap adjustment of a sandwich-like acoustic metamaterial plate with a frequency-displacement feedback control method
Several types of acoustic metamaterials composed of resonant units have been developed to achieve low-frequency bandgaps. In most of these structures, bandgaps are determined by their geometric configurations ...
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Open AccessHost miRNA and mRNA profiles during in DEF and duck after DHAV-1 infection
DHAV-1 is a highly infectious pathogen that can cause acute hepatitis in ducklings. MicroRNA (miRNA) plays an essential regulatory role in virus response. We characterized and compared miRNA and mRNA expressio...
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Publisher Correction: Diagnostic performance of radiomics for predicting arterial plaque vulnerability: a systematic review and meta-analysis
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Open AccessDuck hepatitis A virus utilizes PCBP2 to facilitate viral translation and replication
Duck hepatitis A virus type 1 (DHAV-1) is an important member of the Picornaviridae family that causes highly fatal hepatitis in ducklings. Since picornaviruses have small genomes with limited coding capacity, th...
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Open AccessVector competence of Culex quinquefasciatus for Tembusu virus and viral factors for virus transmission by mosquitoes
The ongoing epidemic of flaviviruses worldwide has underscored the importance of studying flavivirus vector competence, considering their close association with mosquito vectors. Tembusu virus is an avian-rela...
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Open AccessPseudoinvasion and squamous metaplasia/morules in colorectal adenomatous polyp: a case report and literature review
Submucosal pseudoinvasion and squamous metaplasia (SM) are incidental and special morphological findings in colorectal adenomas, and both can mimic invasive carcinoma. The coexistence of these two findings fur...
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Open AccessEfficacy of respiratory support therapies during pulmonary rehabilitation exercise training in chronic obstructive pulmonary disease patients: a systematic review and network meta-analysis
Exercise training is fundamental in pulmonary rehabilitation (PR), but patients with chronic obstructive pulmonary disease (COPD) often struggle with exercise intolerance. Respiratory support during exercise i...
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Open AccessRisk assessment of bridge construction investigated using random forest algorithm
Bridge construction collapse is one of the most common bridge safety accidents. At present, evaluation results are often affected by the ability and experience of the assessor. Therefore, it is difficult to qu...
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Article
Open AccessDistribution characteristics of immune infiltration and lymphovascular invasion in patients with breast cancer skin recurrence
To assess the distribution characteristics of immune infiltration and lymphovascular invasion in breast cancer skin recurrence patients.
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The Current State and Challenges of Clinical Ethics Consultation for Prenatal Diagnosis: A Qualitative Study of Committee Employee Perspectives in China
Clinical ethics consultations (CECs) play an important role in resolving ethical issues in clinical practice worldwide. The government has encouraged the development of CECs in China to address the ethical cha...
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WebLFR: An interactive light field renderer in web browsers
Traditional light field rendering techniques, relying on dense sampling data, can faithfully reproduce photo-realistic and view-dependent effects such as reflection and refraction. However, they consume substa...
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Ethical Challenges in Information Disclosure and Decision-making in Prenatal Testing: A Focus Group Study of Chinese Health Professionals in Maternal and Child Health Services
The international community has proposed a comprehensive strategy to prevent congenital abnormalities. And China, with a high incidence of congenital diseases, has implemented measures including prenatal scree...
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