369 Result(s)

Article

Controlled DNA Delivery Systems

Purpose. Genes are of increasing interest as pharmaceuticals, but current methods for long-term gene delivery are inadequate. Controlled release systems using biocompatible and/or biodegradable polymers offer ma...

Dan Luo, Kim Woodrow-Mumford, Nadya Belcheva, W. Mark Saltzman in Pharmaceutical Research (1999)

Article

Synthetic DNA delivery systems

The ability to safely and efficiently transfer foreign DNA into cells is a fundamental goal in biotechnology. Toward this end, rapid advances have recently been made in our understanding of mechanisms for DNA ...

Dan Luo, W. Mark Saltzman in Nature Biotechnology (2000)

Article

Enhancement of transfection by physical concentration of DNA at the cell surface

Efficient DNA transfection is critical for biological research and new clinical therapies, but the mechanisms responsible for DNA uptake are unknown. Current nonviral transfection methods, empirically designed...

Dan Luo, W. Mark Saltzman in Nature Biotechnology (2000)

Article

Preface

Dan Luo, W. Mark Saltzman in Somatic Cell and Molecular Genetics (2002)

Article

Controlled assembly of dendrimer-like DNA

DNA possesses many desirable chemical/physical properties as a polymeric material. With the myriad of tools available to manipulate DNA¹, there is great potential for using DNA as a generic instead of a genetic m...

Yougen Li, Yolanda D. Tseng, Sang Y. Kwon, Leo d'Espaux, J. Scott Bunch… in Nature Materials (2004)

Chapter and Conference Paper

Ontology Services-Based Information Integration in Mining Telecom Business Intelligence

Ordinary implementation of mining telecom business intelligence (BI) is to simply pack data warehouse (DW), OLAP and data mining engines together. In practice, this type of system cannot adapt to changing or n...

Longbing Cao, Chao Luo, Dan Luo, Li Liu in PRICAI 2004: Trends in Artificial Intelligence (2004)

Article

3,4,5,6-Tetrahydroxyxanthone Protects Against Myocardial Ischemia-Reperfusion Injury in Rats

In the present study, we tested the protective effect of 3,4,5,6-tetrahydroxyxanthone, a synthetic xanthone derivative, on myocardial ischemia-reperfusion injury in rats. Ischemia-reperfusion injury was induce...

Zhong Dai, De-Jian Jiang, Gao-Yun Hu, Yan-Hua Du… in Cardiovascular Drugs and Therapy (2004)

Chapter and Conference Paper

A Framework for Relational Link Discovery

Link discovery is an emerging research direction for extracting evidences and links from multiple data sources. This paper proposes a self-organizing framework for discovering links from multi-relational datab...

Dan Luo, Chao Luo, Chunzhi Zhang in AI 2005: Advances in Artificial Intelligence (2005)

Chapter and Conference Paper

Mining Domain-Driven Correlations in Stock Markets

There have been many technical trading rules in stock market since the first stock exchange founded. Along with the developing of computer technology, the technical trading rules are playing more and more impo...

Li Lin, Dan Luo, Li Liu in AI 2005: Advances in Artificial Intelligence (2005)

Chapter and Conference Paper

Ontology Transformation in Multiple Domains

We have proposed a new approach called ontology services-driven integration of business intelligence (BI) to designing an integrated BI platform. In such a BI platform, multiple ontological domains may get involv...

Longbing Cao, Dan Luo, Chao Luo, Li Liu in AI 2004: Advances in Artificial Intelligence (2005)

Article

Nanotechnology and DNA Delivery

Nonviral DNA delivery systems have great therapeutic and prophylactic potential, but their clinical utility has been limited by three major barriers: (1) inefficient uptake by the cell, (2) insufficient releas...

Dan Luo in MRS Bulletin (2005)

Article

The impact of NiO on microstructure and electrical property of solid oxide fuel cell anode

Ni-Ce_0.8Sm_0.2O_1.9(Ni-SDC) cermet was selected as anode material for reduced temperature (800°C) solid oxide fuel cells in this study. The influence of NiO powder fabrication methods for Ni-SDC cermets on the elec...

Yan Li, Zhong-yang Luo, Chun-jiang Yu, Dan Luo… in Journal of Zhejiang University-SCIENCE B (2005)

Chapter and Conference Paper

Ontological Engineering in Data Warehousing

In our previous work, we proposed the ontology-based integration of data warehousing to make existing data warehouse system more user-friendly, adaptive and automatic. This paper further outlines a high-level ...

Longbing Cao, Jiarui Ni, Dan Luo in Frontiers of WWW Research and Development - APWeb 2006 (2006)

Chapter and Conference Paper

Fuzzy Genetic Algorithms for Pairs Mining

Pairs mining targets to mine pairs relationship between entities such as between stocks and markets in financial data mining. It has emerged as a kind of promising data mining applications. Due to practical co...

Longbing Cao, Dan Luo, Chengqi Zhang in PRICAI 2006: Trends in Artificial Intelligence (2006)

Protocol

A Dendrimer-Like DNA-Based Vector for DNA Delivery: A Viral and Nonviral Hybrid Approach

DNA can be used as a generic delivery vector in addition to its genetic role as a antigen expression vector. This is inspired in part by the fact that DNA molecules are true polymers. Surprisingly, DNA molecul...

Dan Luo, Yougen Li, Soong Ho Um, Yen Cu in DNA Vaccines (2006)

Article

Dendrimer-like DNA-based fluorescence nanobarcodes

A major challenge in clinical diagnostics and environmental analysis is the difficulty in rapid and sensitive detection of multiple target molecules simultaneously (i.e., multiplexed detections). Our group has...

Soong Ho Um, Jong Bum Lee, Sang Yeon Kwon, Yougen Li, Dan Luo in Nature Protocols (2006)

Article

Effects of Ar ion assisted deposition on the optical and electrical characteristics of electron-beam-evaporated amorphous Si films

In this paper, the effects of Ar ion bombardment during the electron beam evaporation deposition of the amorphous Si film were investigated. it was found that the bombardment increases the light absorption by ...

Xiong-wen Shu, Chen Xu, Zeng-xia Tian, Dan Luo, Guang-di Shen in Optoelectronics Letters (2006)

Article

Enzyme-catalysed assembly of DNA hydrogel

DNA is a remarkable polymer that can be manipulated by a large number of molecular tools including enzymes¹. A variety of geometric objects, periodic arrays and nanoscale devices have been constructed^2,3,4,5,6,7,

Soong Ho Um, Jong Bum Lee, Nokyoung Park, Sang Yeon Kwon… in Nature Materials (2006)

Chapter and Conference Paper

Mining High Impact Exceptional Behavior Patterns

In the real world, exceptional behavior can be seen in many situations such as security-oriented fields. Such behavior is rare and dispersed, while some of them may be associated with significant impact on the...

Longbing Cao, Yanchang Zhao… in Emerging Technologies in Knowledge Discove… (2007)