Papers by MANTECH PUBLICATIONS
Mantechpublications, 2021
Traditional Herbal medicine plays a significant role in the treatment of epilepsy. Though herbal ... more Traditional Herbal medicine plays a significant role in the treatment of epilepsy. Though herbal medicine is widely used in antiepileptic treatment, there is a pack of robust evidence for efficacy and toxicity of most herbs l.
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Mantechpublications, 2021
Liver injury due to herbal and dietary supplements is well described in the literature and its in... more Liver injury due to herbal and dietary supplements is well described in the literature and its incidence has been on the rise in the past decade. Labelling an herbal product as non-medicinal and as a supplement precludes protocols needed for testing, trials and marketing criteria. This has led to rampant use of clinically unproven multi-herb-based drugs use for a myriad of lifestyle diseases. In this report, we discuss a new dietary weight loss supplement, Safe Lean™ that was found to be the cause of liver injury in a young obese woman that resolved after discontinuation and discuss current literature on component, toxicology and chemical analysis of the offending drug.
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Mantechpublications, 2022
Nutraceuticals products have many health benefits other than nutrition. Nutraceuticals are food o... more Nutraceuticals products have many health benefits other than nutrition. Nutraceuticals are food or food products that provide both nutrition and health benefits and used in treatment or prevention of many diseases. Nowadays nutraceuticals are in prominent interest of all countries owing to their prospective nutritional, safety, therapeutic effects. The present review focuses on some plants that have multiple therapeutic effects but are underutilized or barely used. Plants food and their other parts could be an important source of functional food ingredients and health booster compounds with high nutraceutical value. These underutilized plants can prevent many chronic diseases. The given nutraceuticals such as Black plum (Jamun), Jackfruit, Millet have many physiological benefits but are underutilized. Many studies have been done on the nutritional properties of these plant and many articles on the use of the various parts of these plants for their therapeutic effects were found. The comprehensive study is done to highlight their nutritional, health benefits to promote their utilization.
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Mantechpublication, 2021
Medicinal plants are very popular in different traditional medicines due to their diverse pharmac... more Medicinal plants are very popular in different traditional medicines due to their diverse pharmacological potentials and lesser side effects in biological systems. Piper nigrum L. (Family Piperaceae) is a well-known spice considered as "The King of spices" among various spices. It contains a pungent alkaloid "piperine," which is known to possess many pharmacological actions. Piperine increases the bioavailability of many drugs and nutrients by inhibiting various metabolising enzymes. Piper nigrum L and its active constituent "Piperine" exhibit diverse pharmacological activities like antihypertensive, antiplatelet, antioxidant, antitumor, anti-asthmatics, analgesic, anti-inflammatory, anti-diarrheal, antispasmodic, antidepressants, immunomodulatory, anticonvulsant, anti-thyroids, antibacterial, antifungal, hepato-protective, insecticidal and larvicidal activities etc. The current review article is aimed to provide an updated literature review on the recent advancement of pharmacognosy, chemistry and pharmacological activities of
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Mantechpublications, 2021
Trachyspermum ammi (L.) Sprague or commonly Ajwain is an herbaceous herb belonging to the family ... more Trachyspermum ammi (L.) Sprague or commonly Ajwain is an herbaceous herb belonging to the family Apiaceae and vastly grows in Egypt, Iran, Pakistan, Afghanistan, and India as well as European region. Known as Zenyan or Nankhah in medical and pharmaceutical manuscript of medieval Persia, seeds of Ajwain were highly administered by traditional healers and traditionally employed for different ailments. Due to its various chemicalconstituents, the herb seeds were also evaluated for its numerous pharmacological properties. Accordingly, current work was carried out to review the traditional and modern pharmacological properties of Ajwain regarding current and medieval reports. To this, respective databases were searched for the terms ‘Trachyspermum ammi’, ‘Carum copticum’, ‘Ajwain’ and ‘Ajowan’ without limitation up to early 2013. Information on the herb was gathered via electronic search using Pubmed, Scopus, Google scholar and SID (for articles in Persian language) as well as medical and pharmaceutical manuscripts of Persian medicine. Ajwain seeds revealed to possess antiseptic, stimulant, carminative, diuretic, anesthetic, antimicrobial, antiviral, nematicidal, antiulcer, antihypertensive, antitussive, bronchodilatory, antiplatelet and hepatoprotective as well as antihyperlipidemic effects, many of those were remarked by early Persian physicians. With reference to these pharmacological activities, Ajwain seeds can be a good candidate for to be applied in clinical practice. However, in spite of various experimental and animal studies, lack of comprehensive clinical trials aimed on regarded effects is still remained to reconfirm the traditional knowledge. Main constituents include an essential oil of Trachycpermum ammi called thymol which constitutes 35-60% of the essential oil (2.5 to 5% in the dried fruits). There is also α-pinene, p-cymene, limonene and γ-terpinene found in the seed.
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Mantech Publications, 2021
Bacopa monnieri is a nervine tonic famous for its memory and attention enhancement functions. It ... more Bacopa monnieri is a nervine tonic famous for its memory and attention enhancement functions. It is a well-known memory booster Indian herb commo nly given to infants to boost memory power intelligence, and mental health. It is also called Brahmi, a name derived from Brahma, the creator god of the Hindu pantheon of deities. It is celebrated for its diversity of usage. It is said that the use of Bacopa monnieri for memory enhancement goes back 3000 years or more in India, when it was cited for its medicinal properties, especially the memory-enhancing capacity, in the Vedic texts "Athar-Ved Samhita" (3:1) of 800 B.C. and in Ayurveda.
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Mantech Publications, 2021
The fruits of Piper Longum Linn. They are very well-known medicines for respiratory tract disease... more The fruits of Piper Longum Linn. They are very well-known medicines for respiratory tract disease, viz. cough, bronchitis, asthma, etc. as a counterirritant analgesic when applied locally for muscular pains and inflammation and as general tonic and hematinic. They are carminative and known to enhance the bioavailability of food and drugs. In this paper, recently developed micropropagation method by tissue culture and molecular basis of genotypic differentiation between the male and female plants, using randomly amplified polymorphic DNA (RAPD) technique and development of sex associated DNA markers have been discussed along with some medicinal and pharmacological properties of the spice (1) .
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Mantech Publications, 2022
Alzheimer's is one of the foremost common causes of dementedness that influence nerve cells in va... more Alzheimer's is one of the foremost common causes of dementedness that influence nerve cells in varied elements of the brain. Pathologically it's caused by intracellular neurofibrillary tangles and animates things starch like macromolecules and leads to the deposition of plaques that impede the communication between the nerve cells leading to this neurodegenerative illness. The genetic risk issue related to this illness is a mutation in APP, PSEN1 and PSEN2 genes. Also, diet and nutrition play quite a necessary role within the development, likewise as a bar of Alzheimer's illness. The biomarker used for the sighting of the illness ought to be able to completely differentiate between different causes of dementedness and may be able to detect it at an early stage. Any utilization of evoked pluripotent stem cells has been verified to be an efficient treatment for the cure of this illness. The target of this review is to spotlight the pathway that results in this illness and the vegetative cell treatment of this illness.
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Mantech Publications, 2022
Herbal medications are in significant demand for primary healthcare all over the globe because of... more Herbal medications are in significant demand for primary healthcare all over the globe because of their broad biological activities, higher safety margins, and economic rates. Herbs are used in traditional medicine for treatment of various ailments including alzimer's disease, ageing, irritable bowel syndrome, skin diseases, chronic heart failure, carcinoma, etc. Almost all the plants on this earth possess an antioxidant activity which may be directly or indirectly helping in precaution and treatment of this enlisted particular disease here. Solanum xanthocarpum is widely growing herb, referred as Kantakari in Gujarati, known for its antitussive activity have been evaluated for its antioxidant action and compared individually its alcoholic and aqueous extract for the activity. The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract.
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Mantech Publications, 2021
Chewing gum is one of the most common confectionary products consumed worldwide, especially by th... more Chewing gum is one of the most common confectionary products consumed worldwide, especially by the teenagers. Although the roots of chewing gum belongs to the western culture, but it's branches are well embedded into the Indian subcontinent also. There has been an exponential growth in the chewing gum market in India in last ten years. A very simple question, although majority of people would not have had ever thought of it before unfolding the wrapper, "how good or bad is this chewing gum for oral health?" had incited an innumerable studies in this field. Through this article, the author aims to provide the gist of significant studies being carried out till date regarding chewing gums. The objective of this article is to correlate the various facts and fiction sailing in the sea of chewing gum market with scientifically proven results, and help our fellow dentists to guide their patients in deciding "what to chew and what not to chew?"
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Mantech Publications, 2021
Objective: Rose oil is obtained from the petals of difference Rosa Species especially Rosa centif... more Objective: Rose oil is obtained from the petals of difference Rosa Species especially Rosa centifolia L. and Rosa damascena Mill. Various pharmacological properties have been attributed to rose Oil. The aim of the present study was to review the rose oil Therapeutic effects which had been clinically evaluated in trial Studies. Rosa species commonly known as rose (Family Rosaceae) are among the most popular and widely used medicinal plants all over the world. They are originated from the Middle East but are cultivated all over the world. Rose oil is the essential oil extracted from the petals of Rosa species especially R. damascena and R. centifolia. Some historical evidence shows that rose oil is originated from Greece.Currently, the main producing countries of this essential oil are Bulgaria, Turkey, and Morocco. This oil is semisolid, pale, yellow, and very expensive. R. damascena is an ornamental plant and beside perfuming effect, several pharmacological properties including anti-HIV, antibacterial, antioxidant, antitussive, hypnotic, antidiabetic, and relaxant effect on tracheal chains have been reported for this plant. This article is a comprehensive review on pharmacological effects of R. damascena.
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Mantech Publications, 2021
Insomnia disorder affects an oversized proportion of the population on a situational, perennial o... more Insomnia disorder affects an oversized proportion of the population on a situational, perennial or chronic basis and is among the foremost common complaints in practice. The disorder is preponderantly characterised by discontentment with sleep length or quality and difficulties initiating or maintaining sleep, at the side of substantial distress and impairments of daytime functioning. A sleep study isn't habitually indicated for analysis of sleep disorder. psychological feature behavioral medical care for sleep disorder (CBT-I) is that the mainstay of treatment and may be a safe and effective approach. The key challenge of CBT-I is that the lack of clinicians to implement it. The newer generation nonbenzodiazepines (e.g., zolpidem, zaleplon) area unit used as first-line pharmacotherapy for chronic sleep disorder. Newer medication active on targets apart from the gammaaminobutyric acid receptor area unit currently obtainable, however clear treatment tips area unit required. 1 We can use flavourer medication for sleep disorder like this, Sarpagandha,
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Mantech Publications, 2024
Quality by design (QbD) is an important part in today's pharmaceutical quality developments. Qual... more Quality by design (QbD) is an important part in today's pharmaceutical quality developments. Quality design (QBD) is a modern and systematic approach to product development and pharmaceutical quality. Quality by design is a concept proposed by well-known quality expert Joseph M. Juran. This paper presents Pharmaceutical Quality by Design (QbD) and how it can be used to ensure pharmaceutical quality. QbD provides a comprehensive framework that integrates quality principles, risk assessment, and knowledge management throughout the product lifecycle. This explores the key concepts and principles of QbD, including the use of Quality Target Product Profile (QTPP), Critical Quality Attributes (CQAs), and Critical Process Parameters (CPPs). The implementation of QbD involves the application of various tools and methodologies, such as design of experiments (DoE), risk assessment techniques, and process analytical technology (PAT). The objective of this review is to discuss the concept of quality by design and describe its application in pharmaceutical product development.
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Mantech Publications, 2024
This paper investigates how Industry 4.0 technologies contribute to environmental sustainability ... more This paper investigates how Industry 4.0 technologies contribute to environmental sustainability in today's industry. It introduces key Industry 4.0 technologies, emphasizing their role and the importance of environmental awareness. The article outlines how these technologies advance sustainability. A concise literature review summarizes key findings and improvements needed in this area. This work explores the environmental impact of Industry 4.0 technologies using case studies and empirical evidence. It also highlights data analytics and machine learning for sustainable decision-making, along with energy efficiency and resource optimization in manufacturing, referencing quantifying studies. The study delves into Industry 4.0's role in a circular economy and waste reduction, by addressing implementation challenges and opportunities. Concluding with a brief discussion on emerging trends and their implications for sustainability, the article underscores the ongoing relevance of Industry 4.0 in promoting environmental awareness and sustainability.
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mantech publications , 2023
Enterprise Resource Planning (ERP) is now being hailed as a foundation for integrating organisati... more Enterprise Resource Planning (ERP) is now being hailed as a foundation for integrating organisation-wide information systems. ERP systems link the entire organisation's operations together, such as accounting, finance, human resources, manufacturing and distribution, etc. Moreover, they also connect the organisation to its customers and suppliers through the different stages of the product or the process life cycle. There are very few studies conducted about implementing ERP systems in the construction industry, particularly for construction contractors. The focus so far has been on client organisations, engineering and design firms. This paper aims to investigate the suitability and implementation status of ERP systems in contractor firms. The methodology employed is a mix of literature review, market studies and detailed questionnaire survey. It is found that the majority of contractor firms have awareness about the ERP systems, but very few organisations have so far implemented such systems. The major reason is that the implementation of any ERP system needs huge investment in time, money and resources. However, when implemented to solve the right problems, these ERP systems can be a powerful tool for business improvement.
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mantech publications , 2023
Slope stability analysis is a rapidly developing area of study in geotechnical engineering as it ... more Slope stability analysis is a rapidly developing area of study in geotechnical engineering as it has gained importance after some major slope failure catastrophe. Providing a slope that is economical and safe is a great concern in the construction industry. A slope is considered stable if the forces available to resist the movement are greater than the force driving the movement. A number of slope failures in recent years call for slope analysis and possible preventive measures. The paper aims to provide an overview of the research work carried out, which focuses on the factors affecting the slope stability like sudden seepage pressure, erosion, tectonic activities, etc., mechanism of the slope failure e, numerical analysis. Also, the paper aims to review the common methods to mitigate the failure.
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Engineering & Technology, 2023
Construction projects are becoming increasingly common in developing countries. The need for rapi... more Construction projects are becoming increasingly common in developing countries. The need for rapid infrastructure development has resulted in the design and implementation of large scope and size projects in terms of complexity and costs. Time and cost are the lifelines of every project in the construction industry. The project managers and other project professionals aim to control the time and cost and ensure that the projects finish on time without any time overrun and without any cost overruns, with perfect management principles to complete the project. In this context, a qualitative research study has been undertaken in this work, to analyse the reasons for time and cost overrun in construction projects. It is most important to study, analyses and evaluate the causes and effects of the common factors leading to the cost and time overruns constraints and suggest the best and suitable mitigation measures to overcome time and cost overrun constraints.
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Aramid Fibre and Kevlar Fibre Wrapping, 2023
Recently, the utilisation of FRP composites is one of the advanced procedures for repairing, stre... more Recently, the utilisation of FRP composites is one of the advanced procedures for repairing, strengthening, or retrofitting the existing structures to resist the higher loads and rectify the damage issues. This paper displays the experimental investigation of the use of unidirectional Basalt fibre, Aramid fibre and Kevlar fibre wrapping to strengthen the beam-column joints, which are the critical regions of the structures. Twenty-seven interior beam-column joints were cast for this study and were named virgin specimens. These specimens were tested up to failure point. The damaged specimens were rehabilitated using nine different wrapping configurations, including both single and hybrid wrapping. For each type of wrapping configuration, three specimens were tested. This study is just limited to static loading. The effect of the different wrapping techniques has been concentrated on. The performance of the Rehabilitated specimens concerning load-carrying capacity at first crack and Ultimate deflection is compared with that of virgin specimens.
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mantech publications, 2023
The decreasing labour shortage is the biggest challenge in the construction industry.
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mantech publications, 2023
Scouring of the river bed material surrounding the bridge pier is a major cause of the failure of... more Scouring of the river bed material surrounding the bridge pier is a major cause of the failure of the pier. So many researchers have been done on scour depth estimation, but not so much focus is addressed to find the countermeasures. Countermeasures can be used to either strengthen the river bed or to alter the current around the pier. Scour monitoring is a crucial aspect to minimise scouring. The paper studies different methods to monitor scouring. The review focuses on one of the countermeasures to reduce the scouring slot. The scouring varies according to change in the shape, dimension, and position of the slot. Scour monitoring devices can be different according to the site condition.
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