Journal of nuclear medicine technology, Jan 15, 2015
Cardiac stress testing, gated cardiac imaging and monitoring critical patients expose the nuclear... more Cardiac stress testing, gated cardiac imaging and monitoring critical patients expose the nuclear medicine technologist to the electrocardiogram (ECG). Basic ECG interpretation skills are essential for the nuclear medicine technologist to enhance patient care and to recognise key arrhythmias. This article provides an insight into the anatomy of an ECG trace, basic ECG interpretation and a case example typical in the nuclear medicine environment.
The Journal of Alternative and Complementary Medicine, 2009
A novel antithrombotic agent, lumbrokinase, was evaluated in this pilot study for its efficacy in... more A novel antithrombotic agent, lumbrokinase, was evaluated in this pilot study for its efficacy in the treatment of symptomatic stable angina. This was a single-armed cohort study. The study was conducted at the National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia. The study comprised 10 patients who had coronary artery disease and stable angina and who consented to the trial. Patients were treated with oral lumbrokinase for 30 consecutive days in addition to their standard medical therapy. Stress technetium-99m sestamibi myocardial perfusion imaging (MPI) was performed before and at the conclusion of the active treatment period. The degree and extent of inducible ischemia observed on the myocardial perfusion images were evaluated using the previously validated semiquantitative indices (Summed Stress Score and Summed Difference Score). Following active treatment, the mean Summed Stress Score and Summed Difference Score deceased by 39% and 37%, respectively. The anginal symptom was ameliorated in 6 of 10 patients. No adverse reaction including major or minor bleeding was observed. This paper represents the first description of the use of oral lumbrokinase in the treatment of chronic coronary artery disease with objective assessment using MPI. Oral lumbrokinase improves regional myocardial perfusion in patients with stable angina.
Journal of applied physiology (Bethesda, Md. : 1985), Jan 28, 2016
Studies investigating the relationship between heart rate (HR) and arterial stiffness or wave ref... more Studies investigating the relationship between heart rate (HR) and arterial stiffness or wave reflections have commonly induced HR changes through in situ cardiac pacing. Although pacing produces consistent HR changes, hemodynamics can be different with different pacing modalities. Whether the differences impact on the HR relationship with arterial stiffness or wave reflections is unknown. In the present study, 48 subjects (mean age 78±10 (SD), 9 female) with in situ cardiac pacemakers were paced at 60, 70, 80, 90 and 100 bpm under atrial, atrioventricular or ventricular pacing. At each paced heart rate, brachial cuff-based pulse wave analysis was used to determine central haemodynamic parameters, including ejection duration (ED) and augmentation index (AIx). Wave separation analysis was used to determine wave reflection magnitude (RM) and reflection index (RI). Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). Pacing modality was found to have signific...
Carotid-femoral pulse wave velocity (cfPWV) quantifies large artery stiffness, it is used in hemo... more Carotid-femoral pulse wave velocity (cfPWV) quantifies large artery stiffness, it is used in hemodynamic research and is considered a useful cardiovascular clinical marker. cfPWV is blood pressure (BP) dependent. Intrinsic heart rate (HR) dependency of cfPWV is unknown because increasing HR is commonly accompanied by increasing BP. This study aims to quantify cfPWV dependency on acute, sympathovagal-independent changes in HR, independent of BP. Individuals (n=52, age 40-93 years, 11 female) with in situ cardiac pacemakers or cardioverter defibrillators were paced at 60, 70, 80, 90, and 100 bpm. BP and cfPWV were measured at each HR. Both cfPWV (mean [95% CI], 0.31 [0.26-0.37] m/s per 10 bpm; P<0.001) and central aortic diastolic pressure (3.78 [3.40-4.17] mm Hg/10 bpm; P<0.001) increased with HR. The HR effect on cfPWV was isolated by correcting the BP effects by 3 different methods: (1) statistically, by a linear mixed model; (2) mathematically, using an exponential relations...
We thank Dr Tabibian 1 for the comments and interest in our recent article on red blood cell scin... more We thank Dr Tabibian 1 for the comments and interest in our recent article on red blood cell scintigraphy in gastrointestinal hemorrhage. 2 Although our intention was not to provide some definitive measure of sensitivity or specificity but rather to provide a very broad ...
Journal of nuclear medicine technology, Jan 15, 2015
Cardiac stress testing, gated cardiac imaging and monitoring critical patients expose the nuclear... more Cardiac stress testing, gated cardiac imaging and monitoring critical patients expose the nuclear medicine technologist to the electrocardiogram (ECG). Basic ECG interpretation skills are essential for the nuclear medicine technologist to enhance patient care and to recognise key arrhythmias. This article provides an insight into the anatomy of an ECG trace, basic ECG interpretation and a case example typical in the nuclear medicine environment.
The Journal of Alternative and Complementary Medicine, 2009
A novel antithrombotic agent, lumbrokinase, was evaluated in this pilot study for its efficacy in... more A novel antithrombotic agent, lumbrokinase, was evaluated in this pilot study for its efficacy in the treatment of symptomatic stable angina. This was a single-armed cohort study. The study was conducted at the National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia. The study comprised 10 patients who had coronary artery disease and stable angina and who consented to the trial. Patients were treated with oral lumbrokinase for 30 consecutive days in addition to their standard medical therapy. Stress technetium-99m sestamibi myocardial perfusion imaging (MPI) was performed before and at the conclusion of the active treatment period. The degree and extent of inducible ischemia observed on the myocardial perfusion images were evaluated using the previously validated semiquantitative indices (Summed Stress Score and Summed Difference Score). Following active treatment, the mean Summed Stress Score and Summed Difference Score deceased by 39% and 37%, respectively. The anginal symptom was ameliorated in 6 of 10 patients. No adverse reaction including major or minor bleeding was observed. This paper represents the first description of the use of oral lumbrokinase in the treatment of chronic coronary artery disease with objective assessment using MPI. Oral lumbrokinase improves regional myocardial perfusion in patients with stable angina.
Journal of applied physiology (Bethesda, Md. : 1985), Jan 28, 2016
Studies investigating the relationship between heart rate (HR) and arterial stiffness or wave ref... more Studies investigating the relationship between heart rate (HR) and arterial stiffness or wave reflections have commonly induced HR changes through in situ cardiac pacing. Although pacing produces consistent HR changes, hemodynamics can be different with different pacing modalities. Whether the differences impact on the HR relationship with arterial stiffness or wave reflections is unknown. In the present study, 48 subjects (mean age 78±10 (SD), 9 female) with in situ cardiac pacemakers were paced at 60, 70, 80, 90 and 100 bpm under atrial, atrioventricular or ventricular pacing. At each paced heart rate, brachial cuff-based pulse wave analysis was used to determine central haemodynamic parameters, including ejection duration (ED) and augmentation index (AIx). Wave separation analysis was used to determine wave reflection magnitude (RM) and reflection index (RI). Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). Pacing modality was found to have signific...
Carotid-femoral pulse wave velocity (cfPWV) quantifies large artery stiffness, it is used in hemo... more Carotid-femoral pulse wave velocity (cfPWV) quantifies large artery stiffness, it is used in hemodynamic research and is considered a useful cardiovascular clinical marker. cfPWV is blood pressure (BP) dependent. Intrinsic heart rate (HR) dependency of cfPWV is unknown because increasing HR is commonly accompanied by increasing BP. This study aims to quantify cfPWV dependency on acute, sympathovagal-independent changes in HR, independent of BP. Individuals (n=52, age 40-93 years, 11 female) with in situ cardiac pacemakers or cardioverter defibrillators were paced at 60, 70, 80, 90, and 100 bpm. BP and cfPWV were measured at each HR. Both cfPWV (mean [95% CI], 0.31 [0.26-0.37] m/s per 10 bpm; P<0.001) and central aortic diastolic pressure (3.78 [3.40-4.17] mm Hg/10 bpm; P<0.001) increased with HR. The HR effect on cfPWV was isolated by correcting the BP effects by 3 different methods: (1) statistically, by a linear mixed model; (2) mathematically, using an exponential relations...
We thank Dr Tabibian 1 for the comments and interest in our recent article on red blood cell scin... more We thank Dr Tabibian 1 for the comments and interest in our recent article on red blood cell scintigraphy in gastrointestinal hemorrhage. 2 Although our intention was not to provide some definitive measure of sensitivity or specificity but rather to provide a very broad ...
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