We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-h... more We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum levels of S100. This is a substudy of the Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial. Serum levels of S100 were measured a posteriori in a core laboratory in samples collected at 24, 48, and 72 h after OHCA. Outcome at 6 months was assessed using the Cerebral Performance Categories Scale (CPC 1-2 = good outcome, CPC 3-5 = poor outcome). We included 687 patients from 29 sites in Europe. Median S100 values were higher in patients with a poor outcome at 24, 48, and 72 h: 0.19 (IQR 0.10-0.49) versus 0.08 (IQR 0.06-0.11) μg/ml, 0.16 (IQR 0.10-0.44) versus 0.07 (IQR 0.06-0.11) μg/L, and 0.13 (IQR 0.08-0.26) versus 0.06 (IQR 0.05-0.09) μg/L (p < 0.001), respectively. The ability to predict outcome was best at 24 h with an AUC of 0.80 (95% CI 0.77...
Purpose Most training studies in patients with chronic heart failure (CHF) do not consider CHF ae... more Purpose Most training studies in patients with chronic heart failure (CHF) do not consider CHF aetiology in the interpretation of the results. About 60% of the patients in those studies have ischemic CHF (IHF) and 40% non-ischemic CHF (NHF). Recently, we conducted a randomized controlled trial to study three different training modalities in 60 patients with severe CHF, with a similar distribution of IHF and NHF patients. In the present post hoc analysis we compared the differences in training results between ischemic and non-ischemic patients. Methods Left ventricular ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), measured with radionuclide ventriculography (RNV) and echocardiography, NT-pro BNP, peak oxygen uptake (peak $V_{{{\rm O}_{2} }} $ ), working capacity and muscular volume were analyzed before and after training in 45 patients training for 40 sessions, 3 times per week. Fifteen patients served as control group. The outcome was analyzed considering the aetiology of CHF, either ischemic or non-ischemic. Results There were no significant differences in improvements of peak $V_{{{\rm O}_{2} }}$ , working capacity and muscular volume between IHF and NHF patients. In NHF patients, EF increased while EDV and ESV decreased after training. These parameters remained unchanged in IHF patients after training. NT-pro BNP decreased significantly in NHF patients and increased in IHF patients after training. In the control group, patients showed a mild improvement of EF and a decrease of NT-pro BNP. Conclusion This post hoc analysis shows that training intervention is associated with significant reverse remodelling in NHF, but not in IHF patients, whereas $ V_{{{\rm O}_{2} }} $ peak and muscle volume improve regardless of CHF aetiology. Future prospective studies are needed to confirm our findings.
Paediatric research analysing the relationship between the easy-to-use anthropometric measures fo... more Paediatric research analysing the relationship between the easy-to-use anthropometric measures for adiposity and cardiometabolic risk factors remains highly controversial in youth. Several studies suggest that only body mass index (BMI), a measure of relative weight, constitutes an accurate predictor, whereas others highlight the potential role of waist-to-hip ratio (WHR), waist circumference (Waist C), and waist-to-height ratio (WHtR). In this study, we examined the effectiveness of adding anthropometric measures of body fat distribution (Waist C Z Score, WHR Z Score and/or WHtR) to BMI Z Score to predict cardiometabolic risk factors in overweight and obese youth. We also examined the consistency of these associations with the "total fat mass + trunk/legs fat mass" and/or the "total fat mass + trunk fat mass" combinations, as assessed by dual energy X-ray absorptiometry (DXA), the gold standard measurement of body composition. Anthropometric and DXA measurements...
Page 1. 608 THE NEW ENGLAND JOURNAL OF MEDICINE March 2, 1995 CORRESPONDENCE SUBFORMS OF CREATINE... more Page 1. 608 THE NEW ENGLAND JOURNAL OF MEDICINE March 2, 1995 CORRESPONDENCE SUBFORMS OF CREATINE KINASE MB IN THE DIAGNOSIS OF MYOCARDIAL INFARCTION To the Editor: Puleo et al. (Sept. ...
Prostate Specific Antigen (PSA) is widely used for the detection and monitoring of prostate cance... more Prostate Specific Antigen (PSA) is widely used for the detection and monitoring of prostate cancer (CAP) but PSA is elevated in many patients with benign prostatic hyperplasia (BPH). The measurement of free PSA may improve the discrimination between CAP and BPH. Free PSA (F-PSA) and total PSA (T-PSA) were measured using kits based on the Enzymun-Test principle. The patient population was composed of 38 untreated CAP patients, 76 BPH patients and 29 prostatitis patients. At cut-off levels of 0.15 for the F-PSA/T-PSA ratio and 10 ng/ml for T-PSA the specificity and sensitivity for detecting CAP were respectively 87% and 84% for F-PSA/T-PSA ratio and 80% and 63% for T-PSA. The F-PSA/T-PSA ratio is more powerful at discriminating between CAP and BPH than T-PSA alone and may contribute to a reduction in unnecessary invasive techniques.
Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin... more Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react predominantly with the native GAD. Various methods have been studied (radio immunoassay [RIA] and enzyme- linked immunosorbent assay [ELISA]). It was observed that at the present time only RIA-tests, in which GAD is presented in fluid phase, are able to detect antibodies.
Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg
All cells, procaryotic and eucaryotic, respond to a rise in environmental temperature by a rapid ... more All cells, procaryotic and eucaryotic, respond to a rise in environmental temperature by a rapid synthesis of a set of specific proteins: the heat shock proteins (HSPs). These HSPs appear to be among the most conserved proteins in nature and certain members of the HSP family are present in non-stressed cells. These observations are reflecting the fact that HSPs serve vital physiological functions as well in normal cells as in stressed cells. In the past few years, various fields of medicine have shown growing interest in the role that the HSPs may play in cellular mechanisms. In this paper we are briefly summarizing the actual knowledge of HSP involvement in carcinogenic and immunological processes.
We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-h... more We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum levels of S100. This is a substudy of the Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial. Serum levels of S100 were measured a posteriori in a core laboratory in samples collected at 24, 48, and 72 h after OHCA. Outcome at 6 months was assessed using the Cerebral Performance Categories Scale (CPC 1-2 = good outcome, CPC 3-5 = poor outcome). We included 687 patients from 29 sites in Europe. Median S100 values were higher in patients with a poor outcome at 24, 48, and 72 h: 0.19 (IQR 0.10-0.49) versus 0.08 (IQR 0.06-0.11) μg/ml, 0.16 (IQR 0.10-0.44) versus 0.07 (IQR 0.06-0.11) μg/L, and 0.13 (IQR 0.08-0.26) versus 0.06 (IQR 0.05-0.09) μg/L (p < 0.001), respectively. The ability to predict outcome was best at 24 h with an AUC of 0.80 (95% CI 0.77...
Purpose Most training studies in patients with chronic heart failure (CHF) do not consider CHF ae... more Purpose Most training studies in patients with chronic heart failure (CHF) do not consider CHF aetiology in the interpretation of the results. About 60% of the patients in those studies have ischemic CHF (IHF) and 40% non-ischemic CHF (NHF). Recently, we conducted a randomized controlled trial to study three different training modalities in 60 patients with severe CHF, with a similar distribution of IHF and NHF patients. In the present post hoc analysis we compared the differences in training results between ischemic and non-ischemic patients. Methods Left ventricular ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), measured with radionuclide ventriculography (RNV) and echocardiography, NT-pro BNP, peak oxygen uptake (peak $V_{{{\rm O}_{2} }} $ ), working capacity and muscular volume were analyzed before and after training in 45 patients training for 40 sessions, 3 times per week. Fifteen patients served as control group. The outcome was analyzed considering the aetiology of CHF, either ischemic or non-ischemic. Results There were no significant differences in improvements of peak $V_{{{\rm O}_{2} }}$ , working capacity and muscular volume between IHF and NHF patients. In NHF patients, EF increased while EDV and ESV decreased after training. These parameters remained unchanged in IHF patients after training. NT-pro BNP decreased significantly in NHF patients and increased in IHF patients after training. In the control group, patients showed a mild improvement of EF and a decrease of NT-pro BNP. Conclusion This post hoc analysis shows that training intervention is associated with significant reverse remodelling in NHF, but not in IHF patients, whereas $ V_{{{\rm O}_{2} }} $ peak and muscle volume improve regardless of CHF aetiology. Future prospective studies are needed to confirm our findings.
Paediatric research analysing the relationship between the easy-to-use anthropometric measures fo... more Paediatric research analysing the relationship between the easy-to-use anthropometric measures for adiposity and cardiometabolic risk factors remains highly controversial in youth. Several studies suggest that only body mass index (BMI), a measure of relative weight, constitutes an accurate predictor, whereas others highlight the potential role of waist-to-hip ratio (WHR), waist circumference (Waist C), and waist-to-height ratio (WHtR). In this study, we examined the effectiveness of adding anthropometric measures of body fat distribution (Waist C Z Score, WHR Z Score and/or WHtR) to BMI Z Score to predict cardiometabolic risk factors in overweight and obese youth. We also examined the consistency of these associations with the "total fat mass + trunk/legs fat mass" and/or the "total fat mass + trunk fat mass" combinations, as assessed by dual energy X-ray absorptiometry (DXA), the gold standard measurement of body composition. Anthropometric and DXA measurements...
Page 1. 608 THE NEW ENGLAND JOURNAL OF MEDICINE March 2, 1995 CORRESPONDENCE SUBFORMS OF CREATINE... more Page 1. 608 THE NEW ENGLAND JOURNAL OF MEDICINE March 2, 1995 CORRESPONDENCE SUBFORMS OF CREATINE KINASE MB IN THE DIAGNOSIS OF MYOCARDIAL INFARCTION To the Editor: Puleo et al. (Sept. ...
Prostate Specific Antigen (PSA) is widely used for the detection and monitoring of prostate cance... more Prostate Specific Antigen (PSA) is widely used for the detection and monitoring of prostate cancer (CAP) but PSA is elevated in many patients with benign prostatic hyperplasia (BPH). The measurement of free PSA may improve the discrimination between CAP and BPH. Free PSA (F-PSA) and total PSA (T-PSA) were measured using kits based on the Enzymun-Test principle. The patient population was composed of 38 untreated CAP patients, 76 BPH patients and 29 prostatitis patients. At cut-off levels of 0.15 for the F-PSA/T-PSA ratio and 10 ng/ml for T-PSA the specificity and sensitivity for detecting CAP were respectively 87% and 84% for F-PSA/T-PSA ratio and 80% and 63% for T-PSA. The F-PSA/T-PSA ratio is more powerful at discriminating between CAP and BPH than T-PSA alone and may contribute to a reduction in unnecessary invasive techniques.
Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin... more Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react predominantly with the native GAD. Various methods have been studied (radio immunoassay [RIA] and enzyme- linked immunosorbent assay [ELISA]). It was observed that at the present time only RIA-tests, in which GAD is presented in fluid phase, are able to detect antibodies.
Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg
All cells, procaryotic and eucaryotic, respond to a rise in environmental temperature by a rapid ... more All cells, procaryotic and eucaryotic, respond to a rise in environmental temperature by a rapid synthesis of a set of specific proteins: the heat shock proteins (HSPs). These HSPs appear to be among the most conserved proteins in nature and certain members of the HSP family are present in non-stressed cells. These observations are reflecting the fact that HSPs serve vital physiological functions as well in normal cells as in stressed cells. In the past few years, various fields of medicine have shown growing interest in the role that the HSPs may play in cellular mechanisms. In this paper we are briefly summarizing the actual knowledge of HSP involvement in carcinogenic and immunological processes.
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