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A linked data platform for finite element biosimulations

Published: 16 September 2015 Publication History

Abstract

Biosimulation models have been recently introduced to understand the exact causative factors that give rise to impairment in human organs. Finite Element Method (FEM) provides a mathematical framework to simulate dynamic biological systems, with applications ranging from human ear, cardiovascular, to neurovascular research. Due to lack of a well-integrated data infrastructure, the steps involved in the execution and comparative evaluation of large Finite Element (FE) simulations are time consuming and are performed in isolated environments. In this paper, we present a Linked Data platform to improve the automation in integration, analysis and visualisation of biosimulation models for the inner-ear (cochlea) mechanics. The proposed platform aims to help domain scientists and clinicians for exploring and analysing Finite Element (FE) numerical data and simulation results obtained from multiple domains such as biological, geometrical, mathematical, physical models. We validate the platform by conducting a qualitative survey and perform quantitative experiments to record overall performance.

References

[1]
T. Berners-Lee. Semantic web - xml2000. http://www.w3.org/2000/Talks/1206-xml2k-tbl/. Accessed: 2015-06-26.
[2]
M. Courtot, N. Juty, C. Knüpfer, D. Waltemath, A. Zhukova, A. Dräger, M. Dumontier, A. Finney, M. Golebiewski, J. Hastings, et al. Controlled vocabularies and semantics in systems biology. Molecular systems biology, 7(1), 2011.
[3]
A. Freitas, M. Jones, K. Asooja, C. Bellos, S. Elliott, S. Stenfelt, P. Hasapis, C. Georgousopoulos, T. Marquardt, N. Filipovic, S. Decker, and R. Sahay. Towards a semantic representation for multi-scale finite element biosimulation experiments. In 13th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2013, Chania, Greece, November 10-13, 2013, pages 1--5, 2013.
[4]
J. H. Gennari, M. L. Neal, B. E. Carlson, and D. L. Cook. Integration of multi-scale biosimulation models via light-weight semantics. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, page 414. NIH Public Access, 2008.
[5]
M. Hucka, A. Finney, H. M. Sauro, H. Bolouri, J. C. Doyle, H. Kitano, A. P. Arkin, B. J. Bornstein, D. Bray, A. Cornish-Bowden, et al. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics, 19(4):524--531, 2003.
[6]
V. Isailovic, M. Obradovic, D. Nikolic, I. Saveljic, and N. D. Filipovic. SIFEM project: Finite element modeling of the cochlea. In 13th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2013, Chania, Greece, November 10-13, 2013, pages 1--4, 2013.
[7]
C. M. Lloyd, M. D. Halstead, and P. F. Nielsen. CellML: its future, present and past. Progress in biophysics and molecular biology, 85(2):433--450, 2004.
[8]
M. Mehdi, A. Iqbal, A. Hogan, A. Hasnain, Y. Khan, S. Decker, and R. Sahay. Discovering domain-specific public SPARQL endpoints: a life-sciences use-case. In 18th International Database Engineering & Applications Symposium, IDEAS 2014, Porto, Portugal, July 7-9, 2014, pages 39--45, 2014.
[9]
S. Merchant, M. McKenna, J. Adams, J. Nadol Jr., J. Fayad, R. Gellibolian, F. Linthicum Jr., A. Ishiyama, I. Lopez, G. Ishiyama, R. Baloh, and C. Platt. Human temporal bone consortium for research resource enhancement. Journal of the Association for Research in Otolaryngology, 9(1):1--4, 2008.
[10]
M. L. Neal, J. H. Gennari, T. Arts, and D. L. Cook. Advances in semantic representation for multiscale biosimulation: A case study in merging models. In R. B. Altman, A. K. Dunker, L. Hunter, T. Murray, and T. E. Klein, editors, Biocomputing 2009: Proceedings of the Pacific Symposium, Kohala Coast, Hawaii, USA, 5-9 January 2009, pages 304--315, 2009.
[11]
S. T. Neely. Finite difference solution of a two-dimensional mathematical model of the cochlea. The Journal of the Acoustical Society of America, 9(1):69, 1981.
[12]
C. Rosse and J. L. Mejino Jr. The foundational model of anatomy ontology. In Anatomy Ontologies for Bioinformatics, pages 59--117. Springer, 2008.
[13]
H. Sauro and F. Bergmann. Standards and ontologies in computational systems biology. Essays Biochem, 45:211--222, 2008.
[14]
W. Sun, Q. Ma, and S. Chen. A framework for automated finite element analysis with an ontology-based approach. Journal of mechanical science and technology, 23(12): 3209--3220, 2009.

Cited By

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  • (2022)An artefact-based workflow for finite element simulation studiesSimulation Modelling Practice and Theory10.1016/j.simpat.2021.102464116(102464)Online publication date: Apr-2022
  • (2016)Demonstrating a Linked Data Visualiser for Finite Element Biosimulations2016 IEEE Tenth International Conference on Semantic Computing (ICSC)10.1109/ICSC.2016.97(174-175)Online publication date: Feb-2016
  • (2015)Extending inner-ear anatomical concepts in the Foundational Model of Anatomy (FMA) ontologyProceedings of the 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)10.1109/BIBE.2015.7367728(1-6)Online publication date: 2-Nov-2015

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cover image ACM Other conferences
SEMANTICS '15: Proceedings of the 11th International Conference on Semantic Systems
September 2015
220 pages
ISBN:9781450334624
DOI:10.1145/2814864
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 16 September 2015

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Author Tags

  1. biosimulation
  2. finite element method
  3. healthcare and life sciences (HCLS)
  4. linked data
  5. reference architecture

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SEMANTiCS '15

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SEMANTICS '15 Paper Acceptance Rate 22 of 97 submissions, 23%;
Overall Acceptance Rate 40 of 182 submissions, 22%

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Cited By

View all
  • (2022)An artefact-based workflow for finite element simulation studiesSimulation Modelling Practice and Theory10.1016/j.simpat.2021.102464116(102464)Online publication date: Apr-2022
  • (2016)Demonstrating a Linked Data Visualiser for Finite Element Biosimulations2016 IEEE Tenth International Conference on Semantic Computing (ICSC)10.1109/ICSC.2016.97(174-175)Online publication date: Feb-2016
  • (2015)Extending inner-ear anatomical concepts in the Foundational Model of Anatomy (FMA) ontologyProceedings of the 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)10.1109/BIBE.2015.7367728(1-6)Online publication date: 2-Nov-2015

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