Nothing Special   »   [go: up one dir, main page]

skip to main content
research-article

Optimization of Multidimensional Clinical Information System for Schizophrenia

Published: 01 January 2021 Publication History

Abstract

Schizophrenia is a serious mental disease whose pathogenesis has not been fully elucidated. Its clinical evaluation and diagnosis still highly depend on the clinical experience of doctors. It is of great scientific value and clinical significance to study the inducing factors and neuropathological mechanism of schizophrenia. Based on the four research problems of schizophrenia, this paper analyzes the data types that need to be stored in clinical trials and scientific research, including basic information, case report data, neuropsychological and cognitive function evaluation, magnetic resonance data, electroencephalogram (EEG) data, and intestinal flora data. Through the demand analysis of the system, including the data management part, data analysis part, the functional demand of the system management part, and the overall nonfunctional demand of the system, the overall architecture design, functional module division, and database table structure design of the system are completed. Adopting Browser/Server (B/S) architecture and front-end and back-end separation mode and applying Java and Python programming language, based on spring framework and database, a multidimensional information management system for schizophrenia is designed and implemented, which includes four modules: data analysis, data management, system management, and security control. In addition, each functional module of the system is designed and implemented in detail, and the software operation flow of each module is illustrated with the sequence diagram. Finally, the multidimensional data of schizophrenia collected in our laboratory were used for system test to verify whether the system can meet the needs of clinical big data management of schizophrenia and the multidimensional information management system of schizophrenia can meet the needs of clinical big data management. The information management system helps schizophrenic researchers to carry out data management and data analysis. It also has advantages that are easy to use, safe, and efficient and has strong scalability in data management, data analysis, and scalability. It reflects the innovation of the system and provides a good platform for the management, research, and analysis of clinical big data of schizophrenia.

References

[1]
C. Cabral, L. Kambeitz-Ilankovic, J. Kambeitz et al., “Classifying schizophrenia using multimodal multivariate pattern recognition analysis: evaluating the impact of individual clinical profiles on the neurodiagnostic performance,” Schizophrenia Bulletin, vol. 42, no. 1, pp. 110–117, 2016.
[2]
B. A. Clementz, J. A. Sweeney, J. P. Hamm et al., “Identification of distinct psychosis biotypes using brain-based biomarkers,” American Journal of Psychiatry, vol. 173, no. 4, pp. 373–384, 2016.
[3]
X. Tan, X. Jiang, Y. He et al., “Automated design and optimization of multitarget schizophrenia drug candidates by deep learning,” European Journal of Medicinal Chemistry, vol. 204, no. 4, 2020.
[4]
A. Kim and E. Cherapkin, “Typological characteristics of affective disorders in cases of paranoid schizophrenia,” European Psychiatry, vol. 3, no. 3, p. 715, 2016.
[5]
C. C. Conway, M. Mansolf, and S. P. Reise, “Ecological validity of a quantitative classification system for mental illness in treatment-seeking adults,” Psychological Assessment, vol. 31, no. 6, pp. 730–740, 2019.
[6]
D. Ben-Zeev, R. Wang, S. Abdullah et al., “Mobile behavioral sensing for outpatients and inpatients with schizophrenia,” Psychiatric Services, vol. 67, no. 5, pp. 558–561, 2016.
[7]
V. D. Calhoun and J. Sui, “Multimodal fusion of brain imaging data: a key to finding the missing link (s) in complex mental illness,” Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 1, no. 3, pp. 230–244, 2016.
[8]
R. C. K. Chan, W. Xie, F.-L. Geng et al., “Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders,” Schizophrenia Bulletin, vol. 42, no. 3, pp. 560–570, 2016.
[9]
Y. Chung, J. Addington, C. E. Bearden et al., “Use of machine learning to determine deviance in neuroanatomical maturity associated with future psychosis in youths at clinically high risk,” JAMA Psychiatry, vol. 75, no. 9, pp. 960–968, 2018.
[10]
L. Bonet, J. Torous, D. Arce, I. Blanquer, and J. Sanjuán, “ReMindCare, an app for daily clinical practice in patients with first episode psychosis: a pragmatic real‐world study protocol,” Early Intervention in Psychiatry, vol. 15, no. 1, pp. 183–192, 2021.
[11]
R. N. Pläschke, E. C. Cieslik, V. I. Müller et al., “On the integrity of functional brain networks in schizophrenia, parkinson’s disease, and advanced age: evidence from connectivity-based single-subject classification,” Human Brain Mapping, vol. 38, no. 12, pp. 5845–5858, 2017.
[12]
W. H. Pinaya, A. Gadelha, O. M. Doyle et al., “Using deep belief network modelling to characterize differences in brain morphometry in schizophrenia,” Scientific Reports, vol. 6, no. 1, pp. 1–9, 2016.
[13]
E. Schwarz, N. T. Doan, G. Pergola et al., “Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder,” Translational Psychiatry, vol. 9, no. 1, pp. 1–3, 2019.
[14]
E. A. Reavis, J. Lee, J. K. Wynn et al., “Assessing neural tuning for object perception in schizophrenia and bipolar disorder with multivariate pattern analysis of fMRI data,” NeuroImage: Clinical, vol. 16, no. 16, pp. 491–497, 2017.
[15]
A. G. Murley, I. Coyle-Gilchrist, M. A. Rouse et al., “Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes,” Brain, vol. 143, no. 5, pp. 1555–1571, 2020.
[16]
D. A. Drossman, “Improving the treatment of irritable bowel syndrome with the rome IV multidimensional clinical profile,” Gastroenterology & Hepatology, vol. 13, no. 11, pp. 694–696, 2017.
[17]
B. Dingenen, L. Blandford, M. Comerford, F. Staes, and S. Mottram, “The assessment of movement health in clinical practice: a multidimensional perspective,” Physical Therapy in Sport, vol. 32, no. 2, pp. 282–292, 2018.
[18]
K. Kreimeyer, M. Foster, A. Pandey et al., “Natural language processing systems for capturing and standardizing unstructured clinical information: a systematic review,” Journal of Biomedical Informatics, vol. 73, no. 3, pp. 14–29, 2017.
[19]
K. Adnan and R. Akbar, “An analytical study of information extraction from unstructured and multidimensional big data,” Journal of Big Data, vol. 6, no. 1, pp. 1–38, 2019.
[20]
H. C. Cheng, R. von Coelln, A. L. Gruber-Baldini, L. M. Shulman, and A. Varshney, “Winnow: interactive visualization of temporal changes in multidimensional clinical data,” in Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, vol. 8, no. 2, pp. 124–133, Boston, MA, USA, August 2017.
[21]
L. Chen and X. Xu, “Effect evaluation of the long-term care insurance (LTCI) system on the health care of the elderly: a review,” Journal of Multidisciplinary Healthcare, vol. 13, pp. 863–875, 2020.
[22]
S. Yang, J. Wang, X. Hao et al., “BiCoSS: toward large-scale cognition brain with multigranular neuromorphic architecture,” IEEE Transactions on Neural Networks and Learning Systems, pp. 1–15, 2021.
[23]
J. Wen, J. Yang, B. Jiang, H. Song, and H. Wung, “Big data driven marine environment information forecasting: a time series prediction network,” IEEE Transactions on Fuzzy Systems, vol. 29, no. 1, pp. 4–18, 2020.
[24]
W. Wei, B. Zhou, D. Połap, and M. Woźniak, “A regional adaptive variational PDE model for computed tomography image reconstruction,” Pattern Recognition, vol. 92, pp. 64–81, 2019.
[25]
M. S. Hossain, G. Muhammad, and N. Guizani, “Explainable AI and mass surveillance system-based healthcare framework to combat COVID-I9 like pandemics,” IEEE Network, vol. 34, no. 4, pp. 126–132, 2020.
[26]
J. S. Almeida, P. P. Rebouças Filho, T. Carneiro et al., “Detecting parkinson’s disease with sustained phonation and speech signals using machine learning techniques,” Pattern Recognition Letters, vol. 125, pp. 55–62, 2019.

Cited By

View all

Recommendations

Comments

Please enable JavaScript to view thecomments powered by Disqus.

Information & Contributors

Information

Published In

cover image Complexity
Complexity  Volume 2021, Issue
2021
20672 pages
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher

John Wiley & Sons, Inc.

United States

Publication History

Published: 01 January 2021

Qualifiers

  • Research-article

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • Downloads (Last 12 months)0
  • Downloads (Last 6 weeks)0
Reflects downloads up to 13 Nov 2024

Other Metrics

Citations

Cited By

View all

View Options

View options

Get Access

Login options

Media

Figures

Other

Tables

Share

Share

Share this Publication link

Share on social media