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View all- Koide A(1989)Designing molecules and crystals by computerIBM Systems Journal10.1147/sj.284.061328:4(613-627)Online publication date: 10-Nov-1989
Cysteine protease is known to degrade amyloid beta peptide which is a causative agent of Alzheimer's disease. This cleavage mechanism has not been studied in detail at the atomic level. Hence, a three-dimensional structure of cysteine protease from ...
The therapeutic strategy employing destabilization of the preformed Aβ fibril by various natural compounds, as studied by experimental and computational methods, has been reported significant in curing Alzheimer’s disease (AD). However,...
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Display Omitted Heat shock protein 70 is an effective anticancer target as it influences many signaling pathways.Key pharmacophore features required for ATPase inhibitory activity of HSP70 were identified by ligand based pharmacophore model.The ...
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