Lycopene destabilizes preformed Aβ fibrils: : Mechanistic insights from all-atom molecular dynamics simulation
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Highlights- Twelve tanshinones, three salvianolic acids and caffeic acid derivatives were evaluated for anti-Alzheimer’s property.
AbstractThe rhizome of Salvia miltiorrhiza has emerged as a rich source of natural therapeutic agents, and its several compounds are supposed to exhibit favorable effects on Alzheimer’s disease (AD). The present work investigate the anti-AD ...
Influence of functional moiety in lupane-type triterpenoids in BACE1 inhibition
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Highlights- Compound 1 to be a potent competitive BACE1 inhibitor.
- Tyr198 as an importance ...
AbstractLupane-type triterpenoids have shown a potential effect against neurodegenerative disorders. Alzheimer’s disease, one of the common neurodegenerative disease, is evident by the accumulation of amyloid-beta (Aβ) plaque in the ...
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Elsevier Ltd.
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Elsevier Science Publishers B. V.
Netherlands
Publication History
Published: 01 August 2023
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