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2 Results for: Author: Villinger, Francois
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- research-articleNovember 2024
Development of a novel representation of drug 3D structures and enhancement of the TSR-based method for probing drug and target interactions
- Tarikul I. Milon,
- Yuhong Wang,
- Ryan L. Fontenot,
- Poorya Khajouie,
- Francois Villinger,
- Vijay Raghavan,
- Wu Xu
Computational Biology and Chemistry (COBC), Volume 112, Issue Chttps://doi.org/10.1016/j.compbiolchem.2024.108117AbstractUnderstanding the mechanisms underlying interactions between drugs and target proteins is critical for drug discovery. In our earlier studies, we introduced the Triangular Spatial Relationship (TSR)-based algorithm, which enables the ...
Graphical AbstractDisplay Omitted
Highlights- A new approach to representing ligand and drug 3D structures is introduced and evaluated.
- A novel algorithm calculating cross TSR keys is developed for enabling comparisons of drug/ligand - target complexes.
- The results demonstrate ...
- doctoral_thesisJanuary 2020
Do Mucosal Immunoglobulin M Antibodies Prevent Mucosal Simian-Human Immunodeficiency Virus Transmission?
AbstractImmunoglobulin M is an ancient antibody class that has been preserved in all vertebrates throughout evolution. The pentameric structure grants immunoglobulin M attractive features to prevent and treat infectious diseases. However, due to ...
