The Impact of Tumor Elongation on Facial Nerve Outcome after Surgery for Koos Grade 3 and 4 Vestibular Schwannomas in the Semi-Sitting Position via the Retrosigmoid Approach
<p>Illustration of two axial T1-Gd-enhanced MR images representing two cases with different radiomic shape parameter elongation.</p> "> Figure 2
<p>ROC curve of elongation in predicting poor facial nerve outcome after VS surgery.</p> "> Figure 3
<p>Forest plots from multivariable binary logistic regression analysis: extent of resection and elongation are independent predictors of poor facial nerve outcome at 3 months after surgery.</p> "> Figure 4
<p>Raincloud plots, box plots, and raw data points illustrate MIB-1 labeling indices among those with an elongation ≤ 0.35 (yellow) and those with an elongation > 0.35 (blue).</p> ">
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Patient Characteristics
2.2. Data Recording
2.3. Surgical Procedure and Follow-Up Regime
2.4. Immunohistochemistry
2.5. Statistics of Institutional Data
3. Results
3.1. Patient Characteristics
3.2. Patient Characteristics in Good and Poor Facial Nerve Outcome
3.3. Association between Elongation and Facial Nerve Outcome
3.4. Association between Shape and Proliferation
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | N = 61 |
---|---|
Median age (years, ±SD) | 57 (15.39) |
Female sex | 32 (57.4%) |
Median preoperative KPS (IQR) | 90 (50–100) |
Dysphagia preoperative | 4 (6.6%) |
Preoperative CN VII dysfunction | |
HB II | 2 (3.3%) |
HB III | 0 |
HB IV | 1 (1.6%) |
Hydrocephalus preoperative | 2 (3.3%) |
Arterial HT | 32 (52.5%) |
Surface area, (mean ± SD), cm2 | 24.34 ± 21.74 |
Tumor volume, (mean ± SD), cm3 | 9.94 ± 12.8 |
Tumor size preoperative (cm) axial (mean ± SD) | 3.16 ± 2.8 |
Flatness | 1.22 ± 0.11 |
Roundness | 0.83 ± 0.06 |
Elongation | 0.46 ± 0.19 |
MIB-1 index (mean ± SD) | 3.0 ± 1.3 |
Koos Grade | |
3 | 23 (37.7%) |
4 | 38 (62.3%) |
Characteristics | Good FNO (n = 50) | Poor FNO (n = 11) | p-Value |
---|---|---|---|
Mean age (years +/− SD) | 53.73 +/− 15.342 | 62.0 +/− 14.327 | 0.096 |
Male sex Female sex | 22 (84.6%) 28 (80.0%) | 4 (15.4%) 7 (20.0%) | 0.75 |
Mean preoperative KPS (+/−SD) | 90.0 +/− 8.08 | 89.1 +/− 8.31 | 0.74 |
Cystic VS | 25 (50.0%) | 8 (72.7%) | 0.32 |
Surface area, (mean ± SD), cm2 | 24.20 +/− 22.87 | 24.92 +/− 17.18 | 0.919 |
Tumor volume, (mean ± SD), cm3 | 10.03 +/− 13.73 | 9.56 +/− 8.43 | 0.914 |
Tumor size (size of tumor preoperative (cm) axial (mean ± SD)) | 3.21 +/− 3.05 | 2.95 +/− 0.89 | 0.77 |
Elongation (+/−SD) | 0.48 +/− 0.20 | 0.36 +/− 0.13 | 0.047 |
MIB-1 index, (mean ± SD) | 3.0 +/− 1.3 | 2.8 +/− 1.3 | 0.61 |
Extent of resection | |||
GTR or NTR STR or partial resection | 22 (71.0%) 28 (93.3%) | 9 (29.0%) 2 (6.7%) | 0.04 |
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Glieme, F.; Haddad, L.; Arlt, F.; Vychopen, M.; Seidel, C.; Barrantes-Freer, A.; Güresir, E.; Wach, J. The Impact of Tumor Elongation on Facial Nerve Outcome after Surgery for Koos Grade 3 and 4 Vestibular Schwannomas in the Semi-Sitting Position via the Retrosigmoid Approach. J. Clin. Med. 2024, 13, 5319. https://doi.org/10.3390/jcm13175319
Glieme F, Haddad L, Arlt F, Vychopen M, Seidel C, Barrantes-Freer A, Güresir E, Wach J. The Impact of Tumor Elongation on Facial Nerve Outcome after Surgery for Koos Grade 3 and 4 Vestibular Schwannomas in the Semi-Sitting Position via the Retrosigmoid Approach. Journal of Clinical Medicine. 2024; 13(17):5319. https://doi.org/10.3390/jcm13175319
Chicago/Turabian StyleGlieme, Franziska, Lisa Haddad, Felix Arlt, Martin Vychopen, Clemens Seidel, Alonso Barrantes-Freer, Erdem Güresir, and Johannes Wach. 2024. "The Impact of Tumor Elongation on Facial Nerve Outcome after Surgery for Koos Grade 3 and 4 Vestibular Schwannomas in the Semi-Sitting Position via the Retrosigmoid Approach" Journal of Clinical Medicine 13, no. 17: 5319. https://doi.org/10.3390/jcm13175319
APA StyleGlieme, F., Haddad, L., Arlt, F., Vychopen, M., Seidel, C., Barrantes-Freer, A., Güresir, E., & Wach, J. (2024). The Impact of Tumor Elongation on Facial Nerve Outcome after Surgery for Koos Grade 3 and 4 Vestibular Schwannomas in the Semi-Sitting Position via the Retrosigmoid Approach. Journal of Clinical Medicine, 13(17), 5319. https://doi.org/10.3390/jcm13175319