A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Q24669850)

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6 February 2020

title

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity (English)

1 reference

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6 February 2020

main subject

adaptive immune system

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6 February 2020

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6 February 2020

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6 February 2020

Jennifer A Doudna

1 reference

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6 February 2020

Emmanuelle Charpentier

series ordinal

object named as

Emmanuelle Charpentier

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language of work or name

English

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publication date

28 June 2012

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6 February 2020

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6 February 2020

volume

337

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issue

6096

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page(s)

816-821

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on focus list of Wikimedia project

6 February 2020

ScienceSource

0 references

cites work

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CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

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Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

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Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

21 April 2017

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Recognition and maturation of effector RNAs in a CRISPR interference pathway

21 April 2017

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Small CRISPR RNAs guide antiviral defense in prokaryotes

21 April 2017

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An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

21 April 2017

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Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)

21 April 2017

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Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

21 April 2017

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A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

21 April 2017

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CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

21 April 2017

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The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

21 April 2017

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Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family

21 April 2017

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 April 2017

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Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

21 April 2017

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Targeting DNA double-strand breaks with TAL effector nucleases

21 April 2017

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A TALE nuclease architecture for efficient genome editing

21 April 2017

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Genome editing with engineered zinc finger nucleases

21 April 2017

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Progress and prospects: zinc-finger nucleases as gene therapy agents

21 April 2017

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VARNA: Interactive drawing and editing of the RNA secondary structure

21 April 2017

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RNA-guided genetic silencing systems in bacteria and archaea

21 April 2017

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RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

21 April 2017

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Evolution and classification of the CRISPR-Cas systems

21 April 2017

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Phage response to CRISPR-encoded resistance in Streptococcus thermophilus

21 April 2017

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Argonaute proteins: key players in RNA silencing

21 April 2017

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Single-copy insertion of transgenes in Caenorhabditis elegans

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Structures of the RNA-guided surveillance complex from a bacterial immune system

21 April 2017

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12 December 2020

Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein.

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12 December 2020

Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage

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Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

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12 December 2020

CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation

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12 December 2020

Self versus non-self discrimination during CRISPR RNA-directed immunity.

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12 December 2020

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

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12 December 2020

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

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12 December 2020

Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site

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12 December 2020

Dicing defence in bacteria

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12 December 2020

Genome Engineering With Zinc-Finger Nucleases

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12 December 2020

CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3

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12 December 2020

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

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12 December 2020

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

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12 December 2020

Genetic manipulation of pathogenic streptococci

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7 January 2021

On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family

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7 January 2021

Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs.

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7 January 2021

The kinetic mechanism of EcoRI endonuclease

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Memory efficient folding algorithms for circular RNA secondary structures

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7 January 2021

Identifiers

DOI

10.1126/SCIENCE.1225829

2 references

Consolidated OpenCitations Corpus – April 2017

202987

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22745249%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

ADS bibcode

2012Sci...337..816J

0 references

202987

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22745249%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

22745249

2 references

Consolidated OpenCitations Corpus – April 2017

202987

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22745249%20AND%20SRC:MED&resulttype=core&format=json