Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers (Q24292693)

19 October 2023

Seon-Yong Jeong

Seon-Yong

Jeong

1 reference

19 October 2023

Brigitte Gaume

Brigitte

Gaume

1 reference

19 October 2023

Yang-Ja Lee

Yang-Ja

Lee

1 reference

19 October 2023

Yi-Te Hsu

Yi-Te

Hsu

1 reference

19 October 2023

Seung-Wook Ryu

Seung-Wook

Ryu

1 reference

19 October 2023

Soo-Han Yoon

Soo-Han

Yoon

1 reference

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

19 October 2023

language of work or name

English

0 references

publication date

19 May 2004

0 references

0 references

0 references

0 references

2146-55

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Structure of Bax: coregulation of dimer formation and intracellular localization

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

The Bcl2 family: regulators of the cellular life-or-death switch

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

The Bcl-2 protein family: arbiters of cell survival

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Pathways of apoptosis in lymphocyte development, homeostasis, and disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Domain swapping: entangling alliances between proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=424420

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600225

Bcl-x(S) can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-x(S) to the mitochondria and its BH3 and loop domains

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600225

Evolution of oligomeric proteins. The unusual case of a dimeric ribonuclease

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/15131699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Generation and characterization of species-specific anti-Bcl-X(L) monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15131699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/15131699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7600225

0 references

Fatcat ID

release_mquqyatdg5g45fz72pceyxnxwe

0 references

PMC publication ID

424420

0 references