Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity (Q24675444)

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Simon A Crawford

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George Hausmann

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Jennifer G Beaumont

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Loes P Parma

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Lin Chen

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Martin Lackmann

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Mark G Hinds

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Jerry M Adams

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David C S Huang

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

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language of work or name

English

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publication date

1 September 2003

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published in

Journal of Cell Biology

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volume

162

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issue

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page(s)

877-87

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cites work

1 reference

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

7 April 2017

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

7 April 2017

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

7 April 2017

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Conformation of the Bax C-terminus regulates subcellular location and cell death

7 April 2017

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The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

7 April 2017

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

7 April 2017

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Movement of Bax from the cytosol to mitochondria during apoptosis

7 April 2017

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Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

7 April 2017

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Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes

7 April 2017

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

7 April 2017

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Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

7 April 2017

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Structure of Bax: coregulation of dimer formation and intracellular localization

7 April 2017

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Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1

7 April 2017

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Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

7 April 2017

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

7 April 2017

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

7 April 2017

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

7 April 2017

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Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

7 April 2017

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

7 April 2017

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

7 April 2017

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

7 April 2017

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Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor

7 April 2017

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Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

7 April 2017

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Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

7 April 2017

1 reference

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bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

7 April 2017

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Mitochondria and apoptosis

7 April 2017

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

7 April 2017

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The Bcl2 family: regulators of the cellular life-or-death switch

7 April 2017

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BCL-2 family members and the mitochondria in apoptosis

7 April 2017

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The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane.

7 April 2017

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

28 September 2017

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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

28 September 2017

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The mitochondrion in apoptosis: how Pandora's box opens

28 September 2017

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Breaking the mitochondrial barrier

28 September 2017

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

28 September 2017

1 reference

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Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

28 September 2017

1 reference

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Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

28 September 2017

1 reference

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BH3-Only proteins-essential initiators of apoptotic cell death

28 September 2017

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Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172834

Bcl-2 family: life-or-death switch

28 September 2017

1 reference

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Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

28 September 2017

1 reference

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Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

28 September 2017

1 reference

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Conversion of Bcl-2 to a Bax-like death effector by caspases

28 September 2017

1 reference

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The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172834

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

28 September 2017

1 reference

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The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

28 September 2017

1 reference

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The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172834

A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture

28 September 2017

1 reference

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The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172834

A modified method for lead staining of thin sections.

28 September 2017

1 reference

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Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation

30 May 2018

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Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

30 May 2018

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Targeting of C-Terminal (Tail)-Anchored Proteins: Understanding how Cytoplasmic Activities are Anchored to Intracellular Membranes

21 January 2018

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Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

21 January 2018

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Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells

28 November 2018

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12 December 2020

Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins

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12 December 2020

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

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12 December 2020

Differential detergent fractionation of isolated hepatocytes: biochemical, immunochemical and two-dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments

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12 December 2020

Single-chain antigen-binding proteins

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12 December 2020

Ultrastructural localization of bcl-2 protein

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12 December 2020