Tugas Baca
Tugas Baca
Tugas Baca
• Diagnosis of PCP is multifactorial and may include clinical suspicion, patient risk factors, laboratory evaluations, chest
radiograph, chest computed tomography (CT), sputum studies, evaluation of bronchoalveolar lavage fluid, or lung biopsies.
• Laboratory findings can be nonspecific for PCP, and of most notable mention is an elevated serum lactate dehydrogenase
(LDH) in HIV-infected patients
Justina Truong; John V. Ashurst, Kingman Regional Medical Center, Pneumocystis Jirovecii Pneumonia, November 23,
2022
Treatment PCP
• First-line treatment choice for HIV-infected and uninfected patients is 21 days of trimethoprim-sulfamethoxazole (TMP-SMX)
• For mild to moderate treatment, TMP 15 to 20 mg/kg/day and SMX 75 to 100 mg/kg/day, given orally in 3 or 4 divided doses or TMP-SMX DS,
two tablets three times per day.
• For moderate to severe cases (e.g., PaO ≤ 60 mmHg, respiratory rate > 25), TMP 15 to 20 mg/kg/day and SMX 75-100 mg/kg/day are given
intravenously (IV) every 6 to 8 hours with a switch to oral when the patient shows clinical improvement
Alternative drug regimens for the treatment of PCP in those with sulfa allergies and mild to moderate disease include:
• Atavaquone 750 mg, orally twice daily for 21 days (must be taken with food).
• Trimethoprim 15 mg/kg/day by mouth twice daily plus dapsone 100 mg by mouth every day
• Primaquine 30 mg daily, plus clindamycin by mouth 450 mg every 6 hours or 600 mg every 8 hours.
Corticosteroids also may be recommended in HIV-uninfected patients with PCP due to the potential for high mortality and fulminant course of illness,.
Dosing for prednisone should be started as soon as possible or within 72 hours of starting treatment for PCP and is as follows:
40 mg by mouth twice per day on days 1 through 5,
40 mg by mouth daily on days 6 through 10
20 mg orally daily on days 11 through 21. IV
Methylprednisone can be given at 75% of the prednisone dose if oral therapy cannot be tolerated. HIV-infected patients who are not already on them
should have antiretroviral therapy (ART) initiated within two weeks of Pneumocystis treatment or as soon as they are stable enough to begin treatment.
Patients usually show slightly worsening clinical signs around days 3 to 4 due to the host's inflammatory response to dying organisms and then
improvement afterward.
Justina Truong; John V. Ashurst, Kingman Regional Medical Center, Pneumocystis Jirovecii Pneumonia, November 23,
2022
TNM 8
Performa Status
Pain management
Post-Obstructive Pneumonia
• Post-obstructive pneumonia
is defined as infection of the
lung parenchyma distal to a
bronchial obstruction.
Rolston KVI, Nesher L. Post-Obstructive Pneumonia in Patients with Cancer: A Review. Infect Dis Ther.
2018 Mar;7(1):29-38.
Demam Berdarah Dengue
Tumor
Kemokin:
chemoattract
ant protein-1
Efusi
Sumber : EFUSI PLEURA MALIGNA: DIAGNOSIS DAN PENATALAKSANAAN TERKINI, Divisi Pulmonologi Bagian FK Unud
PCP (Pneumocytis pneumonia)