Stephen Holt MD-A4M ImmuneSenesense and Anti-Aging AUG07
Stephen Holt MD-A4M ImmuneSenesense and Anti-Aging AUG07
Stephen Holt MD-A4M ImmuneSenesense and Anti-Aging AUG07
and
Anti-Aging Initiatives
•Low fat diets link with calorie reduction and longevity and the role
of fat in the inhibition of CD4 cells and NK cells
•Antioxidants
•Minerals: “A Double-edged Sword” e.g. zinc deficiency weakens
immune responses and promotes atrophy of the thymus gland, but
excess zinc intake decreases cell-mediated immunity in the elderly.
•Vitamins: multiple benefits
•Antioxidants: multiple benefits
•Nutraceuticals, many variable benefits on different aspects of
immune function e.g. mushrooms and their fermentation products,
garlic, echinacea, ginseng, astragalus, teas, turmeric, ginger.
•Popular nutraceuticals: MGN-3, BRM-4, ImmPower, Peak Immune
4, Epicor, AHCC, BioDefense, Clinical Immune Modulator etc.
(trademarks of different companies who produce nutraceutical
products for “immunity”) Synergy is better?
Synergistic COX-2 inhibition
• COX-2 is involved in inflammatory conditions and cancer.
20
CIM
15
10
5
MGN-3
0
0.2 2 20 200
grams/liter
1.05 2
1.8
1
MGN-3
0.95
0.9
1.6
1.4 CIM
1.2
0.85
1
0.8
0.75
CIM 0.8
0.6
0.7 0.4
0.65 0.2 MGN-3
0.6 0
0 2 4 24 0 2 4 24
Hours after consumption of test product Hours after consumption of test product